There is plenty of evidence for macroevolution which you have a need to deny.
Frank, macroevolutionists haven't posted any
EXPERIMENTAL evidence of macroevolution. There have been claims that algae growing in colonies from a single alga is macroevolution (was that your claim?), that transposons are evidence of macroevolution and a couple of others that I can't recall at this moment. This is not experimental evidence. This is like saying, "look, there are reptiles" and: look, there are birds" there's your proof of macroevolution.
What I'm asking for are experiments that demonstrate that large-scale genetic transformation can occur. I gave you a number for that, the adaptive evolution to 3 simultaneous selection pressures targeting only 2 genetic loci.
Now that you are starting to get the idea from the Kishony experiment what it takes for adaptive evolution to work in a single selection pressure environment, you should read his papers on what his researchers had to do to get the experiment to work. Do you know that in the single drug experiment, the experiment won't work if the step increase in drug concentration is too large (that is that it takes more than a single mutation to adapt)? Why do you think that happens?
BTW, you never answered if it is ok to discuss your answer to the Miller challenge at PS.
Frank, anything I say publicly, you are free to discuss publicly. If we ever have a private conversation, unless I request otherwise, you are free to discuss publicly. Let's see if the PS crew can give an experimental example of macroevolution of the adaptive evolution of a lineage to 3 simultaneous selection pressures targeting just two genetic loci. Good luck with that! If HIV can't do it with its huge population, high mutation rate, recombination, and that it isn't driven to extinction, it's hard to imagine any replicator that could adapt to those conditions.
Alan Kleinman said:
It is! Do you see that fixation doesn't have to occur for each adaptation step to occur? Competition is minimal in this experiment because it has a large enough carrying capacity for the colony sizes to reach a population size where there is a reasonable probability of the next adaptive mutation occurring without driving the other variants to extinction.
My comment was similar to Miller's. Unfortunately, I didn't get the result that he got.
I missed that. Did Ken Miller make some comment about the Kishony experiment or my claims about that experiment? Or are you just saying that my question, "Why does it take a billion replications for each adaptive evolutionary step in the Kishony experiment?" is a good question? If that's your comment, there is a good answer to why it takes a billion replications for each adaptive step in the Kishony experiment.