From the linked page "ED-I-TOR-I-AL". Did *YOU* catch that?
Yes. Did *YOU* catch that the "ED-I-TOR-I-AL" was published by the Associate Editor of the "B-M-J", only one of the world's oldest and most trusted medical journals?
This essay was written prior to *any* published data on the efficacy of the vaccines in the real world.
Yes, and it was talking about how the trials were not powered to determine efficacy against severe outcomes from COVID but rather whether or not someone had a mild cough. Do you dispute that point?
It seems more a warning from a professional that can be transmitted to the general public that they (we) should not expect the vaccine to provided magical perfect protection against the disease.
Well, that's a bit of a dilution (to say the least) of what the article ACTUALLY says. It makes the exact point I am trying to make. It begins:
The world has bet the farm on vaccines as the solution to the pandemic, but the trials are not focused on answering the questions many might assume they are. Peter Doshi reports
As phase III trials of covid-19 vaccines reach their target enrolments, officials have been trying to project calm. The US coronavirus czar Anthony Fauci and the Food and Drug Administration leadership have offered public assurances that established procedures will be followed.1234 Only a “safe and effective” vaccine will be approved, they say, and nine vaccine manufacturers issued a rare joint statement pledging not to prematurely seek regulatory review.5
But what will it mean exactly when a vaccine is declared “effective”? To the public this seems fairly obvious. “The primary goal of a covid-19 vaccine is to keep people from getting very sick and dying,” a National Public Radio broadcast said bluntly.6
Peter Hotez, dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston, said, “Ideally, you want an antiviral vaccine to do two things . . . first, reduce the likelihood you will get severely ill and go to the hospital, and two, prevent infection and therefore interrupt disease transmission.”7
Yet the current phase III trials are not actually set up to prove either (table 1). None of the trials currently under way are designed to detect a reduction in any serious outcome such as hospital admissions, use of intensive care, or deaths. Nor are the vaccines being studied to determine whether they can interrupt transmission of the virus.
It's clear what the public's expectations were and what the expectations were of COVID vaccine enthusiast Dr. Peter Hotez. Yet it was known from the beginning that the trials
COULD NOT answer these questions. Public health experts and media alike were content to let people continue to believe that an "effective" vaccine meant what they thought it meant even though it was abundantly clear that the studies could not answer ANY of those questions.
Yes, because they were measuring the effectiveness of the vaccine in preventing infection (and positive tests) and a good number of the infected only had very mild symptoms, yet were still infectious.
Ah. So the vaccine was measured for its efficacy to prevent "very mild symptoms". Thanks for confirming.
Even if the *only* impact was to eliminate mild and stealth infections by 80% it would have still had an impact by reducing spread (those who aren't positive, can't spread).
But the study wasn't designed to look for an impact on reducing spread. It was designed to look for reducing mild coughs. I suppose if you want to attempt to extrapolate this to say that someone without a mild cough can't infect someone that's your prerogative, but that seems a bit of a stretch.
Yes, it's called experimental design. To detect a 50% reduction in hospitalizations you would need a sample large enough for the difference to be statistically significant. For example (and depending on how many std dev medical research uses as a standard) ~100 hospitalizations reducing to ~50 should be enough for statistical significance, but 3 in the placebo group versus 2, or 0, or 1, or 4 in the vaccine group tells us exactly nothing.
The size of the study require to put statistically significant value on hosipitalization would have been very large. It just wasn't feasible.
So the disease wasn't severe enough in the vast majority of people and "it just wasn't feasible" to enroll a population large enough to detect a statistically significant benefit in severe outcomes. Tell me how severe this disease was again?
This was also the scaled-up safety study where all participants were monitored for reactions closely.
Yeah, about that... here's another article from the BMJ you might find interesting.
But, for researchers who were testing Pfizer’s vaccine at several sites in Texas during that autumn, speed may have come at the cost of data integrity and patient safety. A regional director who was employed at the research organisation Ventavia Research Group has told The BMJ that the company falsified data, unblinded patients, employed inadequately trained vaccinators, and was slow to follow up on adverse events reported in Pfizer’s pivotal phase III trial.
Revelations of poor practices at a contract research company helping to carry out Pfizer’s pivotal covid-19 vaccine trial raise questions about data integrity and regulatory oversight. Paul D Thacker reports In autumn 2020 Pfizer’s chairman and chief executive, Albert Bourla, released an open...
www.bmj.com
Doesn't sound like they were being monitored all the closely for adverse events after all.
Finally, the study was largely (or was it entirely) conducted in the summer of 2020 around New York City which didn't have a huge COVID outbreak during the period. If the study had been fortuitously planned for some place in the south where the summer outbreaks occured, it would have been better sampled on disease. (The study also excluded those most vulnerable to death - the elderly and immunocomprimised, which is pretty normal.)
So they tested the vaccine on a largely healthy population that was at low risk to begin with. Pretty smart if you're trying to create marketing hype for the vaccine rather than actually determine if it's efficacious against severe outcomes.
Against *infections*, which (what ever the number was) it was. Not a lie.
Except "infections" was broadly defined to include mild coughs and a positive test. The old axiom "Numbers don't lie. Liars use numbers" comes to mind. While it may not have been a "lie", it was incredibly and intentionally misleading.
In a non-emergency situation (as best I can tell not being a medical researcher), a larger round of tests would have ensued to catch the effectiveness against more rare outcomes (like hospitalization and death) before general distribution.
Yes, because CLINICAL OUTCOMES are what is important. A vaccine that may or may not prevent a mild cough is not all that useful.
Instead, it was demonstrated to be safe,
Of course it was. If you don't follow up on adverse events in the trial, you'll think it's "safe". Can't find what you're not looking for.
so they started to distribute to those most vulnerable. And infections went down and severe outcomes went way down. (I know you've been shown the plots that demonstrate this.)
Most of those plots are based on
highly questionable models. The plots that claim "MILLIONS" were saved by COVID vaccines are some of the most implausible nonsense ever published.
The post-emergency approval data from wide-spread usage is quite definitive for the initial vaccine and the initial variants of the virus.
Sure it is. Because much like the trial itself, there is a considerable and immeasurable healthy-vaccinee bias baked into all of the results.
Perhaps you forget the time from exactly 3 years ago when the first distributions were on the cusp. Many people were almost desperate to get vaccinated.
That's because democrats and liberals in particular had overestimated the actual risk of the virus by many orders of magnitude. If you read the study I posted above regarding scapegoating the unvaccinated, liberals and democrats incorrectly believed that the risk of hospitalization if you were infected with COVID was somewhere around 50%. It was closer to 1%
Second, representative polls done prior to data collection suggest that liberals were more likely to overestimate C19 risks. A Franklin Templeton-Gallup Economics of Recovery Study conducted in the second half of 2020 asked US residents to estimate the percentage of C19 infections that result in hospitalisation (the correct number at the time was between 1% and 5%18). The poll showed that around 41% of Democrats (and 28% of Republicans) estimated this rate to be 50% or higher, and more Republicans (26%) than Democrats (10%) estimated the hospitalisation rate correctly at 1%–5%.
No matter what you think about all other aspects of the pandemic, it is a MASSIVE failing of public health that so many people so severely overestimated the hospitalization rate of an infection. Some might posit that this misperception was by design, because as you correctly stated, these people were DESPERATE to get vaccinated. That desperation was borne from a fear based on wildly inflated perceptions of the risk the disease posed to them.
I mean really, who wants a mild cough anyway? If you can get a vaccine 3 or 4 times a year that ensures you never cough again, who wouldn't want that?!
Others were hesitant in at least wanting to wait and see about adverse reactions first, but large numbers of those who were hesitant eventually decided they wanted it as well.
True enough, but still millions more were coerced into vaccination whether they wanted it or not. The vaccine was apparently so good, we had to threaten people's livelihoods to get them to take it and institute all sorts of illogical and nonsensical mandates and policies that were badly contradictory on their face. This has caused incalculable damage to trust in public health and in vaccinations in general. It's why vaccination rates are down across the board. Those who favored mandating COVID vaccines own this looming public health crisis concerning vaccines.
As for me, I wasn't eager to "go first", but not being in the study area and under 50 I would have to wait until millions had gone first. By the time I got my injections in April 2021, the first signs of reduced infection *and* severe outcomes were already showing up in the older populations that had received protection months earlier and I was eager to get my shot and move on with life.
Still many more NEVER got their shot and moved on with life just fine.
The point is, the vaccine mandates and the prejudicial steps taken to coerce a largely healthy population into getting vaccinated was never justified. The vaccine did not prevent infections. It did not slow transmission. It may have provided a personal benefit to those at the highest risk. It should always have been a personal choice.