tas8831
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- May 5, 2017
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Look at this alleged “same gene” across species...an ALLEGED shared gene...
Human Gene HDLBP (uc002wba.1) a 110-kD protein that specifically binds HDL molecules, which functions in the removal of cellular cholesteral...it is a section 87,092 base pairs long
Rat Gene Hdlbp (NM_172039) which is only 68, 238 base pairs long performs a similar function but apparently not identically.
The allegedly the “SAME GENE” in Yeast, S. cerevisiae Gene SCP160 (YJL080C) functions differently and is primary to cell division, and only has 3,669 base pairs.
Finally, the alleged “SAME GENE” in D. Melongaster, Gene Dp1 (CG5170-RB). Having 9119 base pairs (3 times that of Yeast) seems to do nothing!
Had you considered the possibility that those 'same genes' were not sequenced to the same extent?
When I was in graduate school, we we comparing 2 introns from a gene across several species. We used the human gene - the entire coding region, plus introns, plus 3' and 5' flanking regions - as a reference. For some taxa, our genomic DNA samples were old and we had limited success in sequencing the introns. In others, we had no problems at all. The primers we used to generate PCR fragments were in exons because they were fairly well conserved, and so for some taxa we had not only the introns, but parts of exons as well. several taxa had extensive repetitions in their introns, making one, for instance, nearly 1kb larger than all of the others.
By your implicit logic, we should have concluded that these sequences were not from the SAME GENE, despite the fact that we have amplified fragments using identical primers (30+ years of reading on these subjects should be sufficient for your understanding of the above).
I suggest that the human gene you refer to includes all intronic sequence and flanking regions, whereas the others are limited to smaller regions (e.g., without the flanks, or just mRNA).
In fact, I am willing to bet in it.
What say you?
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