Hay Mark is that 9x% is that in only coding regions which is less than 2%?
96% is the overall sequence identity. The protein coding genes are actually pretty close.
Orthologous proteins in human and chimpanzee are extremely similar, with ~29% being identical and the typical orthologue differing by only two amino acids, one per lineage.
Actually had a scientist that worked on the paper send me a spread sheet of the genes. There are some 40,000 base pairs that diverge, can't recall how many base pairs involved.
Here are some excerpts, I wasn't able to nail down a lot of the percentages as ratio but here are some of the highlights from the paper:
We began by identifying a set of 13,454 pairs of human and chimpanzee genes
KA/KS > 1 implies, but is not a necessary condition for, adaptive or positive selection.
About 5% of the proteins show in-frame indels, but these tend to be small (median = 1 codon)
A total of 585 of the 13,454 human–chimpanzee orthologues (4.4%) have observed KA/KI > 1
Ok, when the KA/KI ratio is over 1 is considered rapidly evolving which is another way of saying significant difference. This is indicating 4.4% but you should realize that most of the genes are involved in immunity and oflactory sense (sense of smell). The only way I was able to track down the brain related genes was through research specialized for that purpose, identifying specific genes and their differences.
We found a total of 53 known or predicted human genes that are either deleted entirely (36) or partially (17) in chimpanzee
There is tentative evidence from in-depth analysis of divergence and diversity that natural selection is not the major contributor to the large-scale patterns of genetic variability in humans
That's about it, I have often heard it said that the 98% the same statement stands with regards to protein coding genes. I really don't see how, it looks like the difference remain somewhat consistent with the overall divergence.
Now the sequence identify may well be close to 98%, in fact I think it is. The thing is there are 50 genes that chimpanzees and humans do not have in common and there are over 500 that have (or would have had to) undergone accelerated evolution as indicated by the KA/KI ratio above 1.
You have to understand, your DNA and my DNA is virtually identical, well over 99% the same. That holds true for any two human beings on the planet. We will have all the same genes with differences being mutations which most often damages the genes function.
With genes you have to make direct comparisons of specific genes, overall comparisons can go down a lot of side roads.
Hang on a sec, this one is important, this is a real world adaptive phenomenon. It happens rather seldom but it's pretty dramatic. Now it can cause disease and disorder as well do nothing at all, don't get me wrong. Just sometimes some pretty dramatic things happen. My favorite example is the arctic fish that has an antifreeze gene, in a virtually identical species in southern waters that gene does not exist in their genomes. What is more, it was not copied from any known gene sequence, it's not a duplication, it's a brand new gene. But wait, there's more, it evolved simultaneously in the northern arctic and southern arctic in distinctly different ways but with the exact same effect, they don't freeze solid.
How? You can forget about random mutations, that is one of the most absurd arguments Darwinians use. There has to be a molecular mechanism that is triggered by sub zero weather and neither I nor anyone has a clue what that mechanism is.
Do yourself a favor, never argue against evolution. Argue against the hidden definition of evolution which are the naturalistic assumptions, not the natural process by which things adapt to their environment.
Grace and peace,
Mark
Grace and peace,
Mark