There are a number of ways the word responsible is not the most appropriate word.
1) Obliged. The only person who can assign obligation is the Lord God Almighty. He acts in accordance with His will. He can choose His own will and it will go along with who He is. As Master I don't think we ought to say what He should or shouldn't do. Job 38.
2) Blame. Responsible is often used in regards to blame. I shall not go further, this is where the blasphemy would occur.
3) Causation is all well and good when looking on a good thing. People can blasphemy here too.
4) Accountable/ answerable. Who should God answer too? There is no higher power.
This is why I don't like the word. I think it should be a verb being used instead. Like 'who sanctifies us, ourselves or God?'
It's just it gives me a shudder when I see us trying to make God responsible.