what make you think that is so different from the number of mutations we need to evolve these functions?
Because the relative proportion of functional versus non-functional sequences is something completely different from the number of mutations required to produce a functional sequence.
They're just not the same thing.
again this is what im talking about- several parts at once or nothing. remember that a single part will not be functional unless the other parts will exist.
There is no basis to assume that a single "part" (whatever that is supposed to mean) will be non-functional on its own.
In the context of the thread topic, the whole discussion is about the relative proportion of functional versus non-functional sequences. And by definition a functional sequence is, well,
functional.
its not the same as lottery since in lottery there are millions of people that by a ticket. so someone should win the lottery usually. this isnt true for proteins evolution- the chance is so low that even if we had billions of mutations during the age of the earth is still too low number (say compare to 10^30).
The point about the lottery analogy is to illustrate the misuse of probability calculations. Right away you spot the error with the lottery claim (e.g. the fact there are multiple possible outcomes), but then make the same error all over again when talking about protein evolution.
In the case of evolution we have far more than billions of mutations to talk about. Even right now there are an estimated 5x10^30 bacteria on Earth; and that's just
right now, not even counting all the various life that has existed on Earth for the past 4 billion years. That's not "billions of mutations". We're talking
orders of magnitudes of orders of magnitudes of orders of magnitudes more than that.
So even if a particular sequence only occurred once in 10^30 instances, there is more than enough of both time and lifeforms to ensure it's probably happened at least once.
At any rate, by your own logic, James Bozeman Jr. shouldn't have won the lottery twice since the odds would be too great:
Florida man claims $3M Lotto jackpot after winning $10M last year
But he did anyway. Which further illustrates why after-the-fact probability calculations (even if they can be meaningfully calculated) aren't particularly useful.