pitabread
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- Jan 29, 2017
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not at all. it is actually shows that the punda's thumb article is incorrect since its not even a functional protein.
Except per the paper you cited, they did identify functional proteins. Trying to claim they aren't functional is again just an exercise in goal-post shifting.
and even if it was true its still irrelevant since if the chance to get a functional protein (according to your article) is about 10^10 then the chance to get a multiprotein system (that contain 3 proteins) is about one to 10^30. using panda's thumb own calculations.
No, that's a gross misuse of probability.
First, the 10^10 number is not a probability; rather it's simply the approximate number of functional sequences among non-functional ones. Calculating an actual probability of emergence of said functional sequences requires more variables.
If you re-read the Panda's Thumb article, they allude to this in the discussion of 1000 liters of pond water filled with bacteria where they state that in just a few thousand generations the probability of such functional sequences arising will approach 1. In other words, it becomes a near certainty.
Second, you would only multiply probabilities in cases where there is strict dependence on a sequence of events. For example, calculating the probability of rolling three ones in a row on a six sided die. The probability of the outcome being strictly dependent on each roll of the dice.
When it comes to protein evolution, even in a multi-protein system, we don't necessarily know what the relative dependence of each step is. Especially when one considers what we know of evolution and that proteins can be multi-functional or undergo functional shifts. We also don't necessarily know the total probability space for potentially viable outcomes.
Finally, even if the relative probability of a specific outcome is extremely small, calculating the probability after-the-fact is meaningless. It would be like calculating the specific probability of a specific individual winning the lottery. The chance of which may be infinitesimally small, but after-the-fact such calculation is irrelevant.
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