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We are mobilizing our military with the expectation of having a vaccine by the end of the year

JackRT

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I don't object concerning mandatory vaccination, it's completely logical all things considered, but human nature being such that it is, you can't force people to do something unless you don't want them to do it at all... Its based on the concept of reverse psychology, tell someone only the rich can have it and you'll have people clamoring to get it... tell someone they have to have it and you'll find protests in the streets.

It's just human nature.

The government should simply announce that anti-vaxers will under no circumstances be permitted to have the COVID-19 vaccine. Human nature being what it is, they will either storm the gates to get it or buy it on the black market.
 
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sfs

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Government pushing a mandatory vaccine would actually have the opposite affect than intended. Less people would get vaccinated if it was made mandatory than if government just let it ride as available to all free of cost.
Did that happen the last time there was mandatory vaccination in the US? Have you seen a lot of smallpox around lately?
 
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Hazelelponi

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Did that happen the last time there was mandatory vaccination in the US? Have you seen a lot of smallpox around lately?

When a vaccination was developed for smallpox, while popular, wasn't originally mandatory. It didn't become mandatory in England and Wales until 1853, yet still didn't stop being endemic in the UK until the 1930's... well over 100 years from the time a potential vaccination was discovered, and 80 years from the time it actually became mandatory. Yet smallpox had a 30% mortality rate with disfiguring scarring of most survivors, far worse than this novel coronavirus on all counts.

People always need time, and will always need time to warm up to new things, even if it may save their life.
 
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ZNP

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When a vaccination was developed for smallpox, while popular, wasn't originally mandatory. It didn't become mandatory in England and Wales until 1853, yet still didn't stop being endemic in the UK until the 1930's... well over 100 years from the time a potential vaccination was discovered, and 80 years from the time it actually became mandatory. Yet smallpox had a 30% mortality rate with disfiguring scarring of most survivors, far worse than this novel coronavirus on all counts.

People always need time, and will always need time to warm up to new things, even if it may save their life.
OK, so 100 years from now we might have this under control. Good to know.
 
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Hazelelponi

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OK, so 100 years from now we might have this under control. Good to know.

I don't think it will be that long... vaccines are no longer new and all it takes is immunity in the majority for a disease to be considered under control, and there's already a majority desiring one and waiting for its development....

Couple that with immunity in the population due to exposure, (natural immunity) and it's not going to be a real issue.
 
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ZNP

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I don't think it will be that long... vaccines are no longer new and all it takes is immunity in the majority for a disease to be considered under control, and there's already a majority desiring one and waiting for its development....

Couple that with immunity in the population due to exposure, (natural immunity) and it's not going to be a real issue.
Well there are others claiming it will be under control by September, so we now have bookends somewhere between 1 and 100 years.

Yes, we have vaccines, but this is worldwide, are we really intending to vaccinate 7 billion people? We have had very limited success doing that so far. Also, it is a relative of the common cold, a virus that mutates frequently, so it is very likely that any vaccine we have six months from now will not be effective against all strains.

My point is that many of the comparisons of this virus with pandemics in the past compare the total impact over a number of years with the impact we have had over a few months. If you say that the first death in the US was in February then you should compare this pandemic with the first 3 months of previous ones. When you do that this one looks every bit as destructive.
 
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sfs

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Well there are others claiming it will be under control by September, so we now have bookends somewhere between 1 and 100 years.
Who is claiming it will be under control by September?
Yes, we have vaccines, but this is worldwide, are we really intending to vaccinate 7 billion people?
Who's 'we' here? I assume the US plans to vaccinate Americans, and maybe we'll throw in a few bucks toward vaccinating all of those other people (you know, the ones who don't really count). Unless our president happens to be peeved with the WHO at the time, that is.
Also, it is a relative of the common cold, a virus that mutates frequently, so it is very likely that any vaccine we have six months from now will not be effective against all strains.
SARS-CoV-2 mutates rather slowly for an RNA virus, and every indication so far is that mutations will take much longer than six months for vaccine escape to become a problem. But updated vaccines will eventually be needed.
 
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hedrick

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I have this vague memory of all the kids at my elementary school lining up in the cafeteria to get vaccinated. Must have been polio.
right. Me too. A few years ago my university had a measles outbreak. We did the same thing. It was open to anyone on campus, even drivers that delivered things to campus. What takes most of the time when I get my flu shot is the paperwork. If someone pays for it, you can just line people up at schools, companies, etc.
 
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ZNP

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Who is claiming it will be under control by September?
DiBlasio, NYC mayor is still under the delusion he will open school up in September, many colleges are still not clear if they could reopen (imagine, people from all over the world staying in dorms, attending lectures, etc). And of course Trump believes we'll open up with our without a vaccine. And that is just the US. India is having big trouble maintaining their lockdown. We could go on, but in every country there are those who are pushing for the economy to be reopened prior to September regardless of the consequences.

Who's 'we' here? I assume the US plans to vaccinate Americans, and maybe we'll throw in a few bucks toward vaccinating all of those other people (you know, the ones who don't really count). Unless our president happens to be peeved with the WHO at the time, that is.
Americans represent 5% of the population. You cannot allow a virus which mutates to remain in 50-80% of the world's population, if you do it will return with new strains every single year.

SARS-CoV-2 mutates rather slowly for an RNA virus, and every indication so far is that mutations will take much longer than six months for vaccine escape to become a problem. But updated vaccines will eventually be needed.
The rate at which it mutates is a function of how many people have it. So if 10 million people infected gives you a year, 100 million infected gives you much, much less than a year, and 1 billion infected, might as well forget it.
 
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sfs

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DiBlasio, NYC mayor is still under the delusion he will open school up in September, many colleges are still not clear if they could reopen (imagine, people from all over the world staying in dorms, attending lectures, etc). And of course Trump believes we'll open up with our without a vaccine. And that is just the US. India is having big trouble maintaining their lockdown. We could go on, but in every country there are those who are pushing for the economy to be reopened prior to September regardless of the consequences.
I meant people who actually know anything. And ending lockdowns doesn't necessarily mean the virus is under control -- it just means a government has given up on that control measure.
Americans represent 5% of the population. You cannot allow a virus which mutates to remain in 50-80% of the world's population, if you do it will return with new strains every single year.
You only have to worry about new strains that become common enough to be a threat. I would hope that in reality there will be a broad effort at world-wide vaccination.
The rate at which it mutates is a function of how many people have it. So if 10 million people infected gives you a year, 100 million infected gives you much, much less than a year, and 1 billion infected, might as well forget it.
That's really not true. Even for influenza, which mutates considerably faster than SARS-CoV-2 and which has many strains already in circulation, it's possible to come up with vaccines every year. I don't see why SARS-CoV-2 should be any different than measles, which if anything mutates faster, transmits more easily, and was very widely spread before vaccination began. And yet we don't need a new measles vaccine every six months.
 
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ZNP

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I meant people who actually know anything. And ending lockdowns doesn't necessarily mean the virus is under control -- it just means a government has given up on that control measure.
what's the difference? I just read that Niger, Liberia, Senegal and Nigeria are reopening mosques. Whether you reopen because "you think" you can or because you have no choice, what is the difference? The effect is going to be the same, which is why comparing this pandemic in the very early stages with the sum total of past pandemics is very misleading.

You only have to worry about new strains that become common enough to be a threat. I would hope that in reality there will be a broad effort at world-wide vaccination.
When we have a vaccine I expect we'll vaccinate the US and 1st world first, if it turns out there is limited immunity to no utility at all, then we wouldn't even bother with the rest of the world.

That's really not true. Even for influenza, which mutates considerably faster than SARS-CoV-2 and which has many strains already in circulation, it's possible to come up with vaccines every year. I don't see why SARS-CoV-2 should be any different than measles, which if anything mutates faster, transmits more easily, and was very widely spread before vaccination began. And yet we don't need a new measles vaccine every six months.
When you say "that's really not true" I assume you are not referring to the basic formula that the rate at which a new and dangerous strain mutates is a function of how many people have it, but rather the conclusion that if 1 billion people have it the vaccine will be pretty much pointless.

Once again, I used your smallpox example to give a worst case example of it taking us 100 years to get it under control, you argued that it would be much faster, because of new technology, etc. But how long did it take for us to get measles under control? Surely that has been around longer than 100 years.

Yes, at some point it will be under control. That is not something that either of us have denied. What I am pointing out is that it is completely unrealistic to think it will be under control in the near future. Best case scenario, and I mean really, really best case scenario, this will no longer be a threat in the US in 12 months. I consider that scenario to be extremely optimistic and borderline absurd, perhaps a 5% possibility.
 
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Hazelelponi

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Best case scenario, and I mean really, really best case scenario, this will no longer be a threat in the US in 12 months. I consider that scenario to be extremely optimistic and borderline absurd, perhaps a 5% possibility

Life is life... it's really nothing to freak out over so may as well have an optimistic outlook and be willing for the goalposts to move some. Sitting around saying the sky is falling is borderline absurd... life will go on regardless. The human race has survived far worse.
 
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sfs

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what's the difference? I just read that Niger, Liberia, Senegal and Nigeria are reopening mosques. Whether you reopen because "you think" you can or because you have no choice, what is the difference? The effect is going to be the same, which is why comparing this pandemic in the very early stages with the sum total of past pandemics is very misleading.
I didn't say it made a difference. I just asked who thought the epidemic was going to be under control by September since that's pretty clearly not going to happen (except in a few places like New Zealand).
When we have a vaccine I expect we'll vaccinate the US and 1st world first, if it turns out there is limited immunity to no utility at all, then we wouldn't even bother with the rest of the world.
We won't even vaccinate the US if the vaccine doesn't work.
When you say "that's really not true" I assume you are not referring to the basic formula that the rate at which a new and dangerous strain mutates is a function of how many people have it, but rather the conclusion that if 1 billion people have it the vaccine will be pretty much pointless.
Actually, both parts are questionable. Given the substitution rate(*) and the number of infections so far, every single mutation that can occur in the virus has already occurred hundreds or thousands of times. What can still occur with more infections is new combinations of mutations. So far, everything I've seen says that likely vaccine targets have not been affected by mutations.

(*) The substitution rate is the rate at which we see new variants appear in individuals. The mutation rate, which includes a large number of deleterious mutations that aren't passed on, is much higher and is quite difficult to measure.

Once again, I used your smallpox example to give a worst case example of it taking us 100 years to get it under control
You're confusing control with elimination. Small pox was controlled in much less than 100 years and even eradicated from many nations. It took a century to eliminate the virus from the world -- something no one is talking about doing for SARS-CoV-2.
But how long did it take for us to get measles under control?
In the US? However long it took to achieve widespread vaccination -- cases plummeted in roughly a year. It took a lot longer for much of the world because they weren't being vaccinated. But measles is mostly well-controlled now -- and we haven't needed a new vaccine yet. So why will we need one for this virus in six months?
Surely that has been around longer than 100 years.
Measles has been around for about 1000 years. It was completely uncontrolled until a usable vaccine was introduced in 1968. Since then, it's been controlled.
What I am pointing out is that it is completely unrealistic to think it will be under control in the near future. Best case scenario, and I mean really, really best case scenario, this will no longer be a threat in the US in 12 months.
It's unrealistic to think we will be able to control this virus in less than 12 months, since we won't have a vaccine until then (itself a highly optimistic target). I haven't suggested otherwise. What I objected to was your claim that a vaccine would start to become ineffective after six months. That seems quite unlikely to me.
 
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ZNP

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I didn't say it made a difference. I just asked who thought the epidemic was going to be under control by September since that's pretty clearly not going to happen (except in a few places like New Zealand).
No one is going to reopen while saying that it is going to be deadly. They will always claim that it is OK now, that the risk is overblown, etc. I'm not interested in divining what people are actually thinking, it is much simpler and more accurate to simply look at what they do.

We won't even vaccinate the US if the vaccine doesn't work.
You won't know that. They'll be vaccinating at an incredible rate for weeks, perhaps during that time there will be stories that some are getting sick even though they were vaccinated, but they'll be investigating, etc. It will be a month or two after the vaccinating that they'll confirm it isn't working. Besides, just like the flu vaccine, even if it doesn't confer total immunity it can still help. If you are targeting 4 antibodies and two are no longer effective you can still get partial immunity.

Actually, both parts are questionable. Given the substitution rate(*) and the number of infections so far, every single mutation that can occur in the virus has already occurred hundreds or thousands of times. What can still occur with more infections is new combinations of mutations. So far, everything I've seen says that likely vaccine targets have not been affected by mutations.

(*) The substitution rate is the rate at which we see new variants appear in individuals. The mutation rate, which includes a large number of deleterious mutations that aren't passed on, is much higher and is quite difficult to measure.


You're confusing control with elimination. Small pox was controlled in much less than 100 years and even eradicated from many nations. It took a century to eliminate the virus from the world -- something no one is talking about doing for SARS-CoV-2.
It all depends on whether or not mutations take place that affect the targets of the vaccine.
when you consider the vast multitude of combinations possible it is very difficult to imagine that won't happen. So since, you are not eradicating it, you can't really control new strains from popping up anymore than last years flu shot may not help this year. Many of the epidemiologists who have gone on record say that it is highly likely that immunity will only last 2-3 years.

It's unrealistic to think we will be able to control this virus in less than 12 months, since we won't have a vaccine until then (itself a highly optimistic target). I haven't suggested otherwise. What I objected to was your claim that a vaccine would start to become ineffective after six months. That seems quite unlikely to me.
OK I'll look for some references. I got this virus in March and was happy that I was now "immune" but then much of what I read poured cold water on that suggesting there may be new strains and that my immunity might only be short-lived if at all. There were a number of cases where they were wondering if people had gotten reinfected, though they have since claimed that they can be attributed to an inaccurate test result.
 
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ZNP

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Other possibilities
  • Studies showing that masks are highly effective turn out to be right.
  • An existing vaccine turns out to work, or at least help significantly.
Yes, I think what is most effective is to reduce the viral lode that you get exposed to. You will get exposed to all kinds of things, but if the viral lode is minute your body will be able to deal with it in most cases. But that means we aren't going back. Subways, trains and buses will be filled with people with masks on. Hopefully everyone will use hand sanitizer the minute they get off the subway. Zoom will dominate, corporate offices will shrink, movie theaters, concert halls, and large stadiums will shrivel up and die. Churches need to move to a small group meetings and Zoom. Hotels will also shrivel up along with airlines as business travel will be greatly minimized. People will continue to travel, but they'll choose to drive in their own car rather than take airplanes, trains, and rental cars.
 
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Hazelelponi

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They are using a lot of med students as well as some healthcare workers in the human trials, so we will have challenges to the vaccine fairly readily.
 
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ZNP

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They are using a lot of med students as well as some healthcare workers in the human trials, so we will have challenges to the vaccine fairly readily.
I don't doubt that they'll be aware of potential shortcomings, but again, the political pressure to say "this works" and not to say anything to the contrary will be immense. The most anyone will say who wants to keep their job will be that "even if it doesn't give you total immunity it will help".
 
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Hazelelponi

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There were a number of cases where they were wondering if people had gotten reinfected, though they have since claimed that they can be attributed to an inaccurate test result.

I think they found some cases that may have either gotten reinfected or just had inaccurate test results but the number was quite small (less than 100 potential cases)

So even if they were reinfections it's such a minute amount that it's an exception in any event.

And natural immunity that "may be short-lived" just means we don't know, but immunity may last only a year or two.. lifelong immunity such as we were able to achieve with polio is always ideal, but even if we can't or dont achieve that even annual immunity is good. Most people who get them get annual flu shots.

If you already have antibodies for COVID you shouldn't get it again before a vaccine comes out or at the least it should be mild enough that the antibodies in your body will be able to fight it before you even realize your sick.

As far as schools opening or potentially opening, that's with the thought process that this isn't especially dangerous to the youth... if this rare new pediatric inflammatory syndrome is definitively linked to the coronavirus, they will likely do remote learning until we have a vaccine...since it's new and we aren't yet sure and it's still fairly rare, we will have to wait on further information I'm sure. Until then, any mention of school is based on current information. No need scaring people if it's not connected.
 
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