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Scientific vs Wrong

Justatruthseeker

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Unfortunately that claim implies you neither know God nor understand sceince...
You should remove yourself from that bubble....

"When people have actual reasons for disagreeing with you, they offer those reasons without hesitation. Strangers on social media will cheerfully check your facts, your logic, and your assumptions. But when you start seeing ad hominem attacks that offer no reasons at all, that might be a sign that people in the mass hysteria bubble don’t understand what is wrong with your point of view except that it sounds more sensible than their own." Scott Adams
 
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Justatruthseeker

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Barbarian observes:
Hence our confidence that science can give us accurate understanding of the physical universe.



Let's test your belief on this. Show me any process, required by evolution, that is ruled out by any law of themodynamics. Let's see what you have.
Strawman, since I clearly related the magical bending, accelerating and expansion of nothing to the violation of the laws of thermodynamics.......



Hall's bacteria, through a series of mutations, evolved a new, irreducibly complex enzyme system. Would you like to learn how that happened?
Except the researchers clearly state it doesn't happen till the 31,000th to 31,500th generation. So that only leaves 30,999th to 31,499th generation that survived despite their claim they couldn't process citrus under those conditions. Yet apparently they did so anyways. Not really, I'm not really interested in your fantasies of how 31,000 generations before they gained the ability they survived anyways.....

Barbarian observes:
Nor would mere random variation give us the diversity of life we see. Darwin's great insight was that evolution is not a random process.



It's directly observed. Perhaps you don't know what "evolution" is.
Perhaps you are simply unable to defend your stance, and that's why you fail to give any reasons....

"When people have actual reasons for disagreeing with you, they offer those reasons without hesitation. Strangers on social media will cheerfully check your facts, your logic, and your assumptions. But when you start seeing ad hominem attacks that offer no reasons at all, that might be a sign that people in the mass hysteria bubble don’t understand what is wrong with your point of view except that it sounds more sensible than their own." Scott Adams


Yep. You don't know what it is. Evolution is a change in allele frequency in a population over time. However, adaptation within a species is evolution, just as speciation is evolution. Both have been directly observed.
Nope, there you go again, confusing observations of microevolution (adaptation) with macroevolution, which has never been observed.


No, that's wrong, too. As you just learned, Darwin's great discovery was that it isn't random.
Hmmm, that's funny, since we learned the exact opposite.

https://evolution.berkeley.edu/evolibrary/article/mutations_07

"Mutations can be beneficial, neutral, or harmful for the organism, but mutations do not "try" to supply what the organism "needs." Factors in the environment may influence the rate of mutation but are not generally thought to influence the direction of mutation. For example, exposure to harmful chemicals may increase the mutation rate, but will not cause more mutations that make the organism resistant to those chemicals. In this respect, mutations are random — whether a particular mutation happens or not is unrelated to how useful that mutation would be."


If all there was, was random mutations, we'd never get the variety of life we see. But as Darwin showed, it is natural selection (which is not random at all) which makes the difference.
Tell that to the Grants which came to the exact opposite conclussion from watching finches in real life not fantasy theory.

https://www.ncbi.nlm.nih.gov/pubmed/28568290

"Hybridization increased additive genetic and environmental variances, increased heritabilities to a moderate extent, and generally strengthened phenotypic and genetic correlations. New additive genetic variance introduced by hybridization is estimated to be two to three orders of magnitude greater than that introduced by mutation.

You see, all we really need is what God gave us for variation to occur. He placed that self repair mechanism their against mutations because they destroy the organism over time......


It's a matter of chance which organism happens to get a useful mutation. But it's not a matter of chance that such organisms tend to leave more offspring. And each generation, those new mutations are the basis for further evolution. That's how it works.
Its a matter of chance that they just happen to be able to survive better in the environment that the once in a blue moon mutation enhanced by accident......


You've been misled. Barry Hall's bacteria, over a series of mutations, evolved a new, irreducibly complex enzyme system. Here's how that happens:

"Natural selection is the differential survival and reproduction of individuals due to differences in phenotype. It is a key mechanism of evolution, the change in the heritable traits characteristic of a population over generations. Charles Darwin popularised the term "natural selection", contrasting it with artificial selection, which is intentional, whereas natural selection is not."
https://en.wikipedia.org/wiki/Mutation

Already shown to be false by experimentation....

https://evolution.berkeley.edu/evolibrary/article/mutations_07

"The Lederberg experiment
In 1952, Esther and Joshua Lederberg performed an experiment that helped show that many mutations are random, not directed. In this experiment, they capitalized on the ease with which bacteria can be grown and maintained. Bacteria grow into isolated colonies on plates. These colonies can be reproduced from an original plate to new plates by "stamping" the original plate with a cloth and then stamping empty plates with the same cloth. Bacteria from each colony are picked up on the cloth and then deposited on the new plates by the cloth.

Esther and Joshua hypothesized that antibiotic resistant strains of bacteria surviving an application of antibiotics had the resistance before their exposure to the antibiotics, not as a result of the exposure. Their experimental set-up is summarized below:

So the penicillin-resistant bacteria were there in the population before they encountered penicillin. They did not evolve resistance in response to exposure to the antibiotic."

So I agree with the experts at Berkley, the bacteria already had the ability to process citrus aerobically, hence their ability to survive for 31,000 generations before the trait became fully dominate and became fixed in the population......


Right. Most of them don't do much of anything. A few are harmful. A very few are useful. Natural selection tends to preserve the useful ones and remove the harmful ones. And that's all that is needed.
Which happened in the first place by pure dumb luck.....

It's like fruit flies. Only the original wild population is even capable of surviving outside of a laboratory setting. All the mutated ones are damaged and would die.....


Right. In Hall's bacteria, for example, there were many more harmful mutations than useful ones. But each generation, it was the useful ones that persisted, and were the raw material for the next round of mutations. It's such an efficient way to improve fitness that engineers have started to copy it for problems that are too complex for design. God knew best, after all.
No, the ones already having the ability to process citrus aerobically survived, while those that didn't have this trait as fully died off, leaving only those that already had the ability to begin with.

Your fantasy doesn't fit the facts.

"The most striking adaptation reported so far is the evolution of aerobic growth on citrate, which is unusual in E. coli, in one population at some point between generations 31,000 and 31,500."

The scientists admit that it isn't impossible, just "unusual" and clearly showed that the full adaptation did not appear until the 31,000th to 31,500th generation. Again impossible if some within the colony did not already posess this adaptation. It simply took 31,000 generations to become fully fixed in the colony, but as the Lederberg experiment showed, some already possessed this ability. Did none ever have this ability beforehand, the researchers would not have used the word "unusual" showing they are aware that it is an ability some already possessed.


Remember, mutations are random, but natural selection is not. And that's why the process isn't random. If you don't understand why, I can give you an experiment that would help you see why.
Without that random mutation, there would be no natural selection.......

You mean you'll give me another misinterpretation like you misinterpreted the E coli experiment because you didn't learn from earlier experiments.....


Right. It's like capitalism. It works, even though it's not planned, even if no one understands why it works. It's just the way God created things.
No sorry, God created things after their Kind, that you refuse to accept what God told you and have fallen in with the world of man, which He warned you their wisdom would lead to your ruin, you should tread carefully......

"13Enter through the narrow gate. For wide is the gate and broad is the way that leads to destruction, and many enter through it. 14But small is the gate and narrow the way that leads to life, and only a few find it. 15Beware of false prophets. They come to you in sheep’s clothing, but inwardly they are ravenous wolves.…"

Why do you seek to rend me to pieces like a wolf and lead me along that broad way?????
 
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Justatruthseeker

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God is Spirit, so any scientist knows better.
Except for Ghost -chasers on TV.
But you have to understand what the Hebrew meant by spirit, not what modern people believe it means.

https://en.wikibooks.org/wiki/Hebrew_Roots/Trinity/Holy_Spirit

"THE HOLY SPIRIT In Hebrew, the original inspired language of the Tanach (Old Testament), the word 'Ruach' cannot be construed as a person. It is a force. It is invisible and like wind, because it can be felt or experienced, but not seen. It is the breath of God which disperses His life-force, His energy and His intentions/mind. It is Yahweh's Spirit which is is omnipresent, but also can be directed in specific ways for specific purposes. It is not His actual Person (which remains incorporeal and outside of the physical dimension) that manifests itself in the world, or which comes to dwell in the hearts and lives of His people.

His spirit can be said to be the emanation of His life-force - i.e. breath

Definition of spirit/ruach: “The basic meaning of ruach is both ‘wind’ or ‘breath,’ but neither is understood as essence; rather it is the power encountered in the breath and the wind, whose whence and whither remains mysterious… 2. ruach as a designation for the wind is necessarily something found in motion with the power to set other things in motion…"

The Hebrew people that transcribed God's words understood it was the power or energy behind the breath or wind. When wind strikes you, you can feel its power to set other things in motion, but can not see it.

"The holy Spirit is not a separate being, but an emanation, a power that proceeds from (goes out from, or exits) the Father, and is poured out upon His people (Isaiah 32:15, 44:3; Acts 2:17)."

The spirit is God's Power.....
 
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The Barbarian

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Barbarian suggests:
Let's test your belief on this. Show me any process, required by evolution, that is ruled out by any law of themodynamics. Let's see what you have.

Strawman, since I clearly related the magical bending, accelerating and expansion of nothing to the violation of the laws of thermodynamics.......

Sorry, whatever it is you're talking about here, is not part of evolutionary theory, either. Would it be too much trouble for you to go and figure out what the theory actually says? It could save a lot of bandwidth for the board and a lot of wasted effort for you.

Barbarian observes:
Hall's bacteria, through a series of mutations, evolved a new, irreducibly complex enzyme system. Would you like to learn how that happened?

Except the researchers clearly state it doesn't happen till the 31,000th to 31,500th generation.

Nope. It happened gradually throughout the study. Perhaps you're confusion Halls experiment with something else.

Barbarian observes:
Nor would mere random variation give us the diversity of life we see. Darwin's great insight was that evolution is not a random process. It's directly observed. Perhaps you don't know what "evolution" is.

Perhaps you are simply unable to defend your stance, and that's why you fail to give any reasons....

I'm guessing that you're personally abusive, because you don't actually know what evolution is. Just for the record, what do you think it is?

"When people have actual reasons for disagreeing with you, they offer those reasons without hesitation. Strangers on social media will cheerfully check your facts, your logic, and your assumptions. But when you start seeing ad hominem attacks that offer no reasons at all, that might be a sign that people in the mass hysteria bubble don’t understand what is wrong with your point of view except that it sounds more sensible than their own." Scott Adams

Yep. You don't know what it is. Evolution is a change in allele frequency in a population over time. However, adaptation within a species is evolution, just as speciation is evolution. Both have been directly observed.


Yep. As you now know, evolution is a change in allele frequency in a population over time. Microevolution is evolution within a species. Macroevolution is evolution of new species. Both have been directly observed. Even many creationists now admit the fact of speciation. Some even admit the evolution of new genera and families. Would you like to learn about that?

Barbarian observes:
No, that's wrong, too. As you just learned, Darwin's great discovery was that it isn't random.

Hmmm, that's funny, since we learned the exact opposite.

https://evolution.berkeley.edu/evolibrary/article/mutations_07

You're confusing mutations which occur randomly, with natural selection, which is the opposite of randomness.

"Mutations can be beneficial, neutral, or harmful for the organism, but mutations do not "try" to supply what the organism "needs." Factors in the environment may influence the rate of mutation but are not generally thought to influence the direction of mutation. For example, exposure to harmful chemicals may increase the mutation rate, but will not cause more mutations that make the organism resistant to those chemicals. In this respect, mutations are random — whether a particular mutation happens or not is unrelated to how useful that mutation would be."

Tell that to the Grants which came to the exact opposite conclussion from watching finches in real life not fantasy theory.

You've been misled by people who are confusing random mutation with natural selection.

The first event that the Grants saw affect the food supply was a drought that occurred in 1977. For 551 days the islands received no rain. Plants withered and finches grew hungry. The tiny seeds the medium ground finches were accustomed to eating grew scarce. Medium ground finches with larger beaks could take advantage of alternate food sources because they could crack open larger seeds. The smaller-beaked birds couldn't do this, so they died of starvation.


In 1978 the Grants returned to Daphne Major to document the effect of the drought on the next generation of medium ground finches. They measured the offspring and compared their beak size to that of the previous (pre-drought) generations. They found the offsprings' beaks to be 3 to 4% larger than their grandparents'. The Grants had documented natural selection in action.

https://www.pbs.org/wgbh/evolution/educators/course/session4/elaborate_b_pop1.html

As you see, the selective pressures were not random, and as a result the evolution of these finches was directed toward greater fitness for the environment at the time.

"Hybridization increased additive genetic and environmental variances, increased heritabilities to a moderate extent, and generally strengthened phenotypic and genetic correlations. New additive genetic variance introduced by hybridization is estimated to be two to three orders of magnitude greater than that introduced by mutation.

And that variation was by mutation. This is why sexual reproduction is favored over asexual reproduction. In asexual reproduction only mutations in one line of organisms can be found in a single organism. However, mutations from other lines can be combined in sexual reproduction.

How do we know they were mutations? Let's consider Adam and Eve. You do agree we are all descended from Adam and Eve, right? The two of them could have had at most, four different versions of each gene (humans only have two copies of each gene). Yet most genes in humans have dozens of alleles. The rest had to have appeared by mutation. Now, when two people produce offspring, the offspring are hybrids, with many different mutated versions of genes.

You see, all we really need is what God gave us for variation to occur.

Sorry, as you now see, that's wrong. If you were right, there could only be four alleles for every gene. And yet there are many, many alleles for most genes. (an allele is a particular version of a gene)

He placed that self repair mechanism their against mutations because they destroy the organism over time......

If so, He did a rather poor job. You have a dozen or so mutations that were not present in either parent.

It's a matter of chance which organism happens to get a useful mutation. But it's not a matter of chance that such organisms tend to leave more offspring. And each generation, those new mutations are the basis for further evolution. That's how it works.

Already shown to be false by experimentation....

Nope.
The Luria–Delbrück experiment (1943) (also called the Fluctuation Test) demonstrates that in bacteria, genetic mutations arise in the absence of selection, rather than being a response to selection. Therefore, Darwin's theory of natural selection acting on random mutations applies to bacteria as well as to more complex organisms. Max Delbrück and Salvador Luria won the 1969 Nobel Prize in Physiology or Medicine in part for this work.
https://en.wikipedia.org/wiki/Luria–Delbrück_experiment

Barbarian observes:
Right. In Hall's bacteria, for example, there were many more harmful mutations than useful ones. But each generation, it was the useful ones that persisted, and were the raw material for the next round of mutations. It's such an efficient way to improve fitness that engineers have started to copy it for problems that are too complex for design. God knew best, after all.

Your fantasy doesn't fit the facts.

As you now see, mutation plus natural selection produced a new enzyme system.

Without that random mutation, there would be no natural selection.......

You're starting to get it. Both random mutation and natural selection determine the direction of evolution. That was Darwin's great discovery.

No sorry, God created things after their Kind,

Of course He did. You just don't approve of the way He did it. You refuse to accept what God told you and have fallen in with the world of man, accepting the man-made doctrine of creationism against His Word.

"13Enter through the narrow gate. For wide is the gate and broad is the way that leads to destruction, and many enter through it. 14But small is the gate and narrow the way that leads to life, and only a few find it. 15Beware of false prophets. They come to you in sheep’s clothing, but inwardly they are ravenous wolves.…"

Let God do it His way, and you won't be troubled by this any more.
 
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Justatruthseeker

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Barbarian suggests:
Let's test your belief on this. Show me any process, required by evolution, that is ruled out by any law of themodynamics. Let's see what you have.



Sorry, whatever it is you're talking about here, is not part of evolutionary theory, either. Would it be too much trouble for you to go and figure out what the theory actually says? It could save a lot of bandwidth for the board and a lot of wasted effort for you.

It's not my fault you forgot what you said in the post I replied to:

The Barbarian said:
Hence our confidence that science can give us accurate understanding of the physical universe."

And my response.....

Agreed. But then I don't consider hypothesizing magical bent, accelerating, expanding nothing in opposition to the laws of thermodynamics as science........ Nor do I consider hypothesizing two birds mating right in front of your nose in opposition to the scientific definitions to be separate species science either.

The physical universe does not imply only evolution, but the ummm universe. Hence my first statement and thermodynamics. You're double-talk and strawmen don't work except in your own mind.....

I'm guessing that you're personally abusive, because you don't actually know what evolution is. Just for the record, what do you think it is?

Now comes the mind reading of your opponent, usually a sign of psychosis...

Says the man that first alluded to using crayons....... and talks about himself in the third person..... don't throw stones first and you may not get one thrown back into your glass house.....

You've been misled by people who are confusing random mutation with natural selection.

The first event that the Grants saw affect the food supply was a drought that occurred in 1977. For 551 days the islands received no rain. Plants withered and finches grew hungry. The tiny seeds the medium ground finches were accustomed to eating grew scarce. Medium ground finches with larger beaks could take advantage of alternate food sources because they could crack open larger seeds. The smaller-beaked birds couldn't do this, so they died of starvation.
Problem, drought equals smaller seeds........

And as per the Grants they observed the smaller billed finches mating with the medium billed finches creating larger billed finches......

In 1978 the Grants returned to Daphne Major to document the effect of the drought on the next generation of medium ground finches. They measured the offspring and compared their beak size to that of the previous (pre-drought) generations. They found the offsprings' beaks to be 3 to 4% larger than their grandparents'. The Grants had documented natural selection in action.
https://www.pbs.org/wgbh/evolution/educators/course/session4/elaborate_b_pop1.html

As you see, the selective pressures were not random, and as a result the evolution of these finches was directed toward greater fitness for the environment at the time.
No, the mating between the smaller billed finches and the medium. Get the fact correct. As they put it...

"Loadings were positive for bill depth (0.60) and width (0.58)"
"Each of the two groups of F, hybrids combined with their backcrosses display heritable variation in all six of the measured traits and in the two synthetic (PC) traits (table 2)."

"Variances generally increase as a result of the addition, especially in those dimensions in which the hybridizing species differ the most. Thus, beak variances increase more than variances of body size traits."

"We suggest that in these instances the creation of individuals in novel genetic and morphological space could provide the starting point of a new evolutionary trajectory, a trajectory that is not easily reached by mutation alone or by directional selection acting on constrained genetic variation."


Your dogma doesn't wash, the Grants disagree with everything you claim they say, but then that's why your telling a story and not quoting or citing their papers.....

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1558-5646.1994.tb01313.x


And that variation was by mutation. This is why sexual reproduction is favored over asexual reproduction. In asexual reproduction only mutations in one line of organisms can be found in a single organism. However, mutations from other lines can be combined in sexual reproduction.

Your belief fails to match the data the Grants found.

"New additive genetic variance introduced by hybridization is estimated to be two to three orders of magnitude greater than that introduced by mutation."

How do we know they were mutations? Let's consider Adam and Eve. You do agree we are all descended from Adam and Eve, right? The two of them could have had at most, four different versions of each gene (humans only have two copies of each gene). Yet most genes in humans have dozens of alleles. The rest had to have appeared by mutation. Now, when two people produce offspring, the offspring are hybrids, with many different mutated versions of genes.



Sorry, as you now see, that's wrong. If you were right, there could only be four alleles for every gene. And yet there are many, many alleles for most genes. (an allele is a particular version of a gene)
Yes, let's consider Adam and Eve....

Because your starting assumption is flawed.....

You start with the incorrect assumption that their genes were less perfect than today, when you need to start from the assumption they were more perfect.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014423/

"However, the vast majority of these elements are inactive in humans, due to a very large fraction being highly degraded by mutation. Due to this degeneracy, estimates of the proportion of the human genome occupied by TEs has varied widely, between one-half and two-thirds."

This vast genome was once more active and able to code for proteins that it no longer can code for due to mutations degrading the genome. This added a robustness to the genome that does not exist today, hence the variation for all the races already existed in the original pair.

Just as over 100 breeds of dogs come from one wolf stock......

So we can increase the robustness of the human genome between 1/2 and 2/3 as we go backwards and remove harmful mutations towards the original pair.

What you "Think" is a problem is simply your incorrect viewpoint and ignoring that the human genome has degraded over time due to mutations, not increased in efficiency.....

Your flawed starting assumptions led you to flawed ending assumptions. A correct starting assumption - more active elements degraded over time by mutations - leads to a correct ending assumption - more variability at the beginning and less now due to degradation.
 
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The Barbarian

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Barbarian observes:
Sorry, whatever it is you're talking about here, is not part of evolutionary theory, either. Would it be too much trouble for you to go and figure out what the theory actually says? It could save a lot of bandwidth for the board and a lot of wasted effort for you.

Bringing up whatever "magical bending" you think might be scientific isn't of much use in this discussion. If you'd calm down a little, you'd probably realize that getting abusive isn't doing your argument any good.

Barbarian observes:
I'm guessing that you're personally abusive, because you don't actually know what evolution is. Just for the record, what do you think it is?

Now comes the mind reading of your opponent, usually a sign of psychosis...

A guess is in inference from evidence. Your behavior is indeed an indication of your mental state.

Says the man that first alluded to using crayons.......

Don't remember that. I think you're confused again.

and talks about himself in the third person.....

Well you know how barbarians always speak of themselves in the third person...

In 1978 the Grants returned to Daphne Major to document the effect of the drought on the next generation of medium ground finches. They measured the offspring and compared their beak size to that of the previous (pre-drought) generations. They found the offsprings' beaks to be 3 to 4% larger than their grandparents'. The Grants had documented natural selection in action.


Sorry, that's what it is. A change in the evironment led to the evolution of birds more fit in the new environment. That's how evolution works.

"We suggest that in these instances the creation of individuals in novel genetic and morphological space could provide the starting point of a new evolutionary trajectory, a trajectory that is not easily reached by mutation alone or by directional selection acting on constrained genetic variation."

Precisely. Neither mutation alone nor selection alone were sufficient. Both agents were necessary, as the quote indicates.

Your dogma doesn't wash, the Grants disagree with everything you claim they say

Someone's badly misled you:

Proc Natl Acad Sci U S A. 1976 Jan;73(1):257-61.
Darwin's finches: population variation and natural selection.
Grant PR, Grant BR, Smith JN, Abbott IJ, Abbott LK.
Within populations of this species, different phenotypes distribute themselves in different habitat patches, select foods of different sizes and hardness, and exploit them with efficiencies that are phenotype- (bill size) dependent. These data constitute indirect evidence that natural selection has a controlling influence over the level of phenotypic variation exhibited by a population. Further evidence is that phenotypes did not survive equally well during the study period; on Daphne island G. fortis was apparently subjected to directional selection on bill tip length and G. scandens to normalizing selection on body weight and bill depth. Other factors which may have contributed to the establishment of a difference in variation between Santa Cruz and Daphne populations are the founder effect, genetic drift, and assortative mating. Annual climatic unpredictability is considered a source of environmental heterogeneity which, through its effect upon food supply, favors large morphological variation. It is predicted that species of large individual size are more influenced by this than are small species, and consequently exhibit greater size-corrected variation. The prediction is tested with data from six Geospiza species, and found to be correct.

But then, that's why you're telling a story; you've clearly never read any of their papers. As you now realize, your belief fails to match the data the Grants found.

Yes, let's consider Adam and Eve....

Sure. Humans have only two copies of each gene. So Adam and Eve could have had at most, four alleles for each gene. But most human genes have dozens of alleles. The rest came about by mutations.

Because your starting assumption is flawed, you assumed that they could have all that variation, but no human could do that.

You start with the incorrect assumption that their genes were less perfect than today,

Nope. Just pointing out a fact; humans have only two copies of each gene. All the other alleles for those genes came about by mutation.

Allele

An allele is a viable DNA (deoxyribonucleic acid) coding that occupies a given locus (position) on a chromosome.


Usually alleles are sequences that code for a gene, but sometimes the term is used to refer to a non-gene sequence.


An individual's genotype for that gene is the set of alleles it happens to possess.


In a diploid organism, one that has two copies of each chromosome, two alleles make up the individual's genotype.

https://www.sciencedaily.com/terms/allele.htm

when you need to start from the assumption they were more perfect.

Perfect or not, humans only have two copies of each gene. So each of them could only have two alleles for each gene. All the rest we see today, evolved by mutation.

There's no way to dodge that fact. Might as well accept it. Maybe you should do a little reading about the issue before you try to explain it to us?
 
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Justatruthseeker

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Perfect or not, humans only have two copies of each gene. So each of them could only have two alleles for each gene. All the rest we see today, evolved by mutation.

There's no way to dodge that fact. Might as well accept it. Maybe you should do a little reading about the issue before you try to explain it to us?

We are going to clear this misconception up right away.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014423/

"However, the vast majority of these elements are inactive in humans, due to a very large fraction being highly degraded by mutation. Due to this degeneracy, estimates of the proportion of the human genome occupied by TEs has varied widely, between one-half and two-thirds."

Can you comprehend this?

They are now inactive because of mutations. Which means they were once active. This increases the number of alleles available for combination by 1/2 to 2/3. The function of them completely unknown.... The only thing mutation has done is highly degrade the once active genomes to the point they became inactive, decreasing the number of alleles available by 1/2 to 2/3, not increasing them....

I understand the vast majority of evolutionists are blinded by cognitive dissonance, but surely you are able to understand that if the vast majority is now inactive because of damaging mutations, that if you go back to where they were once functional, they would add an increased variability. Your claims of mutation adding is not supported. Instead we actually find that the vast majority of the genome, 1/2 to 2/3, has been highly degraded by mutations, not benefited from them.

You are simply willfully blinding yourself to the truth because your ID can not handle the disruption to your entire belief system that accepting the truth entails. 1/2 to 2/3 of the genome is now inactive because mutations damaged them. If those mutations were removed, then 1/2 to 2/3 of the genome would once again be functional - adding a variability that your limited thinking won't allow.

Functions we don't have a clue what they would entail because they are not active now. All removed because of a copy error. I understand accepting truth is hard sometimes, but that's what we do anyways and we go on with a new understanding.

I ask you to accept nothing that biologists don't already know.... that 1/2 to 2/3 of the genome is no longer active because of damaging mutations.

The fact you can not present any rational objection simply shows you are quite aware of the fact that if 1/2 to 2/3 of the inactive genome was again active, new variability not even able to be imagined would arise.

Ever notice people always resort to attacking the other person and not their arguments when the attacking person's arguments are weak? You claim I don't understand, but it is clearly you that refuses to accept that 1/2 to 2/3 of the human genome has been "highly damaged" by mutations to the point it is no longer active. Oh I understand quite well, that's why you are left with only personal attacks instead.
 
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TLK Valentine

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The Barbarian

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Barbarian observes:
Perfect or not, humans only have two copies of each gene. So each of them could only have two alleles for each gene. All the rest we see today, evolved by mutation.

There's no way to dodge that fact. Might as well accept it. Maybe you should do a little reading about the issue before you try to explain it to us?


We are going to clear this misconception up right away.

I don't think you're going to like how this works out for you...

"However, the vast majority of these elements are inactive in humans, due to a very large fraction being highly degraded by mutation.

It used to be thought back in the early 60s, that this was "junk DNA", merely degraded material. It turns out that much of it has other functions. So your story won't work. Most of the truly "junk" stuff are repeats, mere copies of other genes, not new alleles. Much of the other stuff is like the GULO gene, formerly producing vitamin C, but not inactive due to a mutation that damaged it. It didn't matter to primates, since they had diets rich in vitamin C.

Can you comprehend this?

They are now inactive because of mutations.

Some, like the vitamin C gene. But mostly repeats. No sign of alleles for existing genes.

Which means they were once active. This increases the number of alleles available for combination by 1/2 to 2/3.

As you just learned, that wouldn't come close to explaining dozens of alleles for genes in the human genome. And as much of the non-coding DNA has other functions, or are known genes that have been damaged, or are mere repeats of no function, even that wouldn't work.

The function of them completely unknown....

See above. When I was an undergraduate in the 1960s, there were papers being written about the functions of non-coding DNA.

The only thing mutation has done is highly degrade the once active genomes to the point they became inactive, decreasing the number of alleles available by 1/2 to 2/3, not increasing them....

As you see, that belief is not supported by the evidence.

I understand the vast majority of evolutionists are blinded by cognitive dissonance

Surely you must realize by now, that getting ugly is counter-productive for you.

I ask you to accept nothing that biologists don't already know.... that 1/2 to 2/3 of the genome is no longer active because of damaging mutations.

That belief was invalidated a long time ago.
https://www.news-medical.net/life-sciences/Functions-of-Junk-DNA.aspx

The fact you can not present any rational objection simply shows you are quite aware of the fact that if 1/2 to 2/3 of the inactive genome was again active, new variability not even able to be imagined would arise.

Even if you weren't wrong in your thinking about non-coding DNA, it would at best, justify 12 alleles, while many human genes have dozens of alleles. It just isn't going to work for you.

Ever notice people always resort to attacking the other person and not their arguments when the attacking person's arguments are weak?

Yes, I've seen that...

"I understand the vast majority of evolutionists are blinded by cognitive dissonance"

People who do it, seem to never understand how it undermines their arguments.

You claim I don't understand,

It's true that you don't. What you imagine to be junk DNA often has functions that are essential to the organism. And much of it is also identified other genes that have been inactivated and no longer used, such as the GULO gene in humans.

but it is clearly you that refuses to accept that 1/2 to 2/3 of the human genome has been "highly damaged" by mutations to the point it is no longer active.

Read the link on functions of non-coding DNA. You've been misled on this one.

Oh I understand quite well, that's why you are left with only personal attacks instead.

Well, it's certainly something we all want to avoid, um?

Edit: There actually are some cases where humans have more than two copies of each gene. It doesn't make them "perfect", though. It usually makes them dead. And when it doesn't kill them, it usually causes some serious damage. Trisomy 21 (Down's Syndrome) is one such case that isn't lethal.

Hardly perfection.
 
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SkyWriting

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But you have to understand what the Hebrew meant by spirit, not what modern people believe it means.

https://en.wikibooks.org/wiki/Hebrew_Roots/Trinity/Holy_Spirit

"THE HOLY SPIRIT In Hebrew, the original inspired language of the Tanach (Old Testament), the word 'Ruach' cannot be construed as a person. It is a force. It is invisible and like wind, because it can be felt or experienced, but not seen. It is the breath of God which disperses His life-force, His energy and His intentions/mind. It is Yahweh's Spirit which is is omnipresent, but also can be directed in specific ways for specific purposes. It is not His actual Person (which remains incorporeal and outside of the physical dimension) that manifests itself in the world, or which comes to dwell in the hearts and lives of His people.

His spirit can be said to be the emanation of His life-force - i.e. breath

Definition of spirit/ruach: “The basic meaning of ruach is both ‘wind’ or ‘breath,’ but neither is understood as essence; rather it is the power encountered in the breath and the wind, whose whence and whither remains mysterious… 2. ruach as a designation for the wind is necessarily something found in motion with the power to set other things in motion…"

The Hebrew people that transcribed God's words understood it was the power or energy behind the breath or wind. When wind strikes you, you can feel its power to set other things in motion, but can not see it.

"The holy Spirit is not a separate being, but an emanation, a power that proceeds from (goes out from, or exits) the Father, and is poured out upon His people (Isaiah 32:15, 44:3; Acts 2:17)."

The spirit is God's Power.....

God is Spirit. So your analysis works fine.
I think modern people get it.
 
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SkyWriting

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Barbarian suggests:
Let's test your belief on this. Show me any process, required by evolution, that is ruled out by any law of themodynamics. Let's see what you have.

Show me any process of evolution that is a result of any property of materials.
Thermal
chemical, anything.
So far no one has come up with even one.
Let's see what you have.
You'll be the first.
 
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SkyWriting

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How do we know they were mutations? Let's consider Adam and Eve. You do agree we are all descended from Adam and Eve, right? The two of them could have had at most, four different versions of each gene (humans only have two copies of each gene). Yet most genes in humans have dozens of alleles. The rest had to have appeared by mutation.

By God's plans, actually.
 
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TLK Valentine

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By God's plans, actually.

That would mean that "mutation," and therefore, evolution itself, are all part of God's plans...

God, after all, doesn't seem the type to get blindsided very often... or indeed, at all.
 
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The Barbarian

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Show me any process of evolution that is a result of any property of materials.

Nucleic acids replicate themselves, but have built in error rates that provide the random mutations that are required for evolution.
So far no one has come up with even one.

There you go. Now, how about answering the question you dodged?

Show us any process required for evolution that is ruled out by laws of thermodynamics.
Let's see what you have.
You'll be the first.
 
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Justatruthseeker

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I don't think you're going to like how this works out for you...
That's what they all say... and all end up being disappointed...


It used to be thought back in the early 60s, that this was "junk DNA", merely degraded material. It turns out that much of it has other functions. So your story won't work. Most of the truly "junk" stuff are repeats, mere copies of other genes, not new alleles. Much of the other stuff is like the GULO gene, formerly producing vitamin C, but not inactive due to a mutation that damaged it. It didn't matter to primates, since they had diets rich in vitamin C.
No sorry, most of the "junk" stuff are associated with TE's, you do know what they are, correct?

Can you comprehend this?
Apparently better than you since what is still known as non-functional, not "junk" is due to mutations.


Some, like the vitamin C gene. But mostly repeats. No sign of alleles for existing genes.
https://www.gendx.com/SBTengine/Help/SBTengine.html?NewAlleles.html

"With the increased use of high resolution typing techniques like SBT in the diagnostic centers, the discovery of new HLA alleles has gained momentum. In October 2006, the IMGT/HLA version 2.15 database contained 2607 alleles whereas in the same month of 2007 the IMGT/HLA database 2.19 contained 3043 alleles. This is an increase of 436 alleles in 365 days! So on average a new HLA allele is discovered each day. This demonstrates that tissue typers using high resolution techniques should be aware of new alleles whenever they type samples."

Hmmm, and yet there is no sign of new alleles, imagine that......


As you just learned, that wouldn't come close to explaining dozens of alleles for genes in the human genome. And as much of the non-coding DNA has other functions, or are known genes that have been damaged, or are mere repeats of no function, even that wouldn't work.
Hopefully as you just learned starting in 2007 they averaged a new allele discovered at a rate of about 1 per day.........


See above. When I was an undergraduate in the 1960s, there were papers being written about the functions of non-coding DNA.
See above. Go back to school....


As you see, that belief is not supported by the evidence.
that's what you said about new alleles too.....


Surely you must realize by now, that getting ugly is counter-productive for you.
And yet you keep insulting people, and are confused as to why you get insulted back.....


I doubt that.

"However, other regions are not transcribed into proteins, nor are they used to produce RNA molecules and their function is unknown."

Apparently the definition of "unknown" in "unknown" to you.

Even if you weren't wrong in your thinking about non-coding DNA, it would at best, justify 12 alleles, while many human genes have dozens of alleles. It just isn't going to work for you.
That's what you said while not understanding that starting in 2007 they found about 1 per day on average......


Yes, I've seen that...

"I understand the vast majority of evolutionists are blinded by cognitive dissonance"

People who do it, seem to never understand how it undermines their arguments.
Except I recognize the function is "unknown", that mutations made most non-functioning, and that new alleles are being discovered all the time, and that our actual knowledge of the genome is rudimentary at best. I don't suffer from cognitive dissonance by trying to avoid those facts.....


It's true that you don't. What you imagine to be junk DNA often has functions that are essential to the organism. And much of it is also identified other genes that have been inactivated and no longer used, such as the GULO gene in humans.
I already know that. I also know a large fraction is non-functioniung due to mutations and that another large portion is simply "unknown".

""However, other regions are not transcribed into proteins, nor are they used to produce RNA molecules and their function is unknown.""


Read the link on functions of non-coding DNA. You've been misled on this one.
Says the man that didn't know that in 2007 almost one new allele was discovered per day......


Well, it's certainly something we all want to avoid, um?
Then start avoiding it.

Edit: There actually are some cases where humans have more than two copies of each gene. It doesn't make them "perfect", though. It usually makes them dead. And when it doesn't kill them, it usually causes some serious damage. Trisomy 21 (Down's Syndrome) is one such case that isn't lethal.

Hardly perfection.
What does 2 copies have to do with functional versus non-functional because of mutations except attempt to throw a strawman into the mix?????

Agreed, when a mutation isn't neutral, it usually makes you dead or causes such things as cystic fibrosis, sickle cell anemia, Tay-Sachs disease, phenylketonuria and color-blindness, to name a few....
 
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The Barbarian

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That's what they all say... and all end up being disappointed...

Sorry about that. But as you learned, much of what you thought was "junk DNA"has other functions.

Only about 1 percent of DNA is made up of protein-coding genes; the other 99 percent is noncoding. Noncoding DNA does not provide instructions for making proteins. Scientists once thought noncoding DNA was “junk,” with no known purpose. However, it is becoming clear that at least some of it is integral to the function of cells, particularly the control of gene activity. For example, noncoding DNA contains sequences that act as regulatory elements, determining when and where genes are turned on and off. Such elements provide sites for specialized proteins (called transcription factors) to attach (bind) and either activate or repress the process by which the information from genes is turned into proteins (transcription). Noncoding DNA contains many types of regulatory elements:

  • Promoters provide binding sites for the protein machinery that carries out transcription. Promoters are typically found just ahead of the gene on the DNA strand.
  • Enhancers provide binding sites for proteins that help activate transcription. Enhancers can be found on the DNA strand before or after the gene they control, sometimes far away.
  • Silencers provide binding sites for proteins that repress transcription. Like enhancers, silencers can be found before or after the gene they control and can be some distance away on the DNA strand.
  • Insulators provide binding sites for proteins that control transcription in a number of ways. Some prevent enhancers from aiding in transcription (enhancer-blocker insulators). Others prevent structural changes in the DNA that repress gene activity (barrier insulators). Some insulators can function as both an enhancer blocker and a barrier.
Other regions of noncoding DNA provide instructions for the formation of certain kinds of RNA molecules. RNA is a chemical cousin of DNA. Examples of specialized RNA molecules produced from noncoding DNA include transfer RNAs (tRNAs) and ribosomal RNAs (rRNAs), which help assemble protein building blocks (amino acids) into a chain that forms a protein; microRNAs (miRNAs), which are short lengths of RNA that block the process of protein production; and long noncoding RNAs (lncRNAs), which are longer lengths of RNA that have diverse roles in regulating gene activity.

Some structural elements of chromosomes are also part of noncoding DNA. For example, repeated noncoding DNA sequences at the ends of chromosomes form telomeres. Telomeres protect the ends of chromosomes from being degraded during the copying of genetic material. Repetitive noncoding DNA sequences also form satellite DNA, which is a part of other structural elements. Satellite DNA is the basis of the centromere, which is the constriction point of the X-shaped chromosome pair. Satellite DNA also forms heterochromatin, which is densely packed DNA that is important for controlling gene activity and maintaining the structure of chromosomes.

Some noncoding DNA regions, called introns, are located within protein-coding genes but are removed before a protein is made. Regulatory elements, such as enhancers, can be located in introns. Other noncoding regions are found between genes and are known as intergenic regions.

The identity of regulatory elements and other functional regions in noncoding DNA is not completely understood. Researchers are working to understand the location and role of these genetic components.
https://ghr.nlm.nih.gov/primer/basics/noncodingdna


No sorry, most of the "junk" stuff are associated with TE's, you do know what they are, correct?

Well, let's take a look...

Transposon-Derived Non-coding RNAs and Their Function in Plants

Jungnam Cho*

  • The Sainsbury Laboratory, University of Cambridge, Cambridge, United Kingdom

Transposable elements (TEs) are often regarded as harmful genomic factors and indeed they are strongly suppressed by the epigenetic silencing mechanisms. On the other hand, the mobilization of TEs brings about variability of genome and transcriptome which are essential in the survival and evolution of the host species. The vast majority of such controlling TEs influence the neighboring genes in cis by either promoting or repressing the transcriptional activities. Although TEs are highly repetitive in the genomes and transcribed in specific stress conditions or developmental stages, the trans-acting regulatory roles of TE-derived RNAs have been rarely studied. It was only recently that TEs were investigated for their regulatory roles as a form of RNA. Particularly in plants, TEs are ample source of small RNAs such as small interfering (si) RNAs and micro (mi) RNAs. Those TE-derived small RNAs have potentials to affect non-TE transcripts by sequence complementarity, thereby generating novel gene regulatory networks including stress resistance and hybridization barrier. Apart from the small RNAs, a number of long non-coding RNAs (lncRNAs) are originated from TEs in plants. For example, a retrotransposon-derived lncRNA expressed in rice root acts as a decoy RNA or miRNA target mimic which negatively controls miRNA171. The post-transcriptional suppression of miRNA171 in roots ensures the stabilization of the target transcripts encoding SCARECROW-LIKE transcription factors, the key regulators of root development. In this review article, the recent discoveries of the regulatory roles of TE-derived RNAs in plants will be highlighted.


Sorry. TE's are not what you assumed they are.

Perhaps you could help your case by showing us that most non-coding DNA sequences are remnants of other alleles for various existing genes. What do you have?

Hmmm, and yet there is no sign of new alleles, imagine that......

Development. 2017 Jun 1;144(11):1959-1965. doi: 10.1242/dev.146407. Epub 2017 Apr 28.
New alleles of the wheat domestication gene Q reveal multiple roles in growth and reproductive development.
Greenwood JR1,2, Finnegan EJ1, Watanabe N3, Trevaskis B1, Swain SM4.

Sorry. Go back to school....

And once again, you see that being abusive has damaged you here. Try to do better.

Barbarian, regarding the notion that Adam and Eve were "perfect" because they had more than 2 alleles for each gene:
There actually are some cases where humans have more than two copies of each gene. It doesn't make them "perfect", though. It usually makes them dead. And when it doesn't kill them, it usually causes some serious damage. Trisomy 21 (Down's Syndrome) is one such case that isn't lethal.

Hardly perfection.

that's what you said about new alleles too.....

Nope. You're confusing polyploidy with a new allele. You, for example, have at least a dozen new alleles, but you are unlikely to be polyploid, since you're alive.

Instead of getting upset and abusive, focus on what you're trying to persuade us about. It can only make you more credible.

What does 2 copies have to do with functional versus non-functional

Normal humans have 2 copies of each gene, which may be different alleles. Those who have more than 2 copies usually end up dead before birth, and those that don't are most often mentally or physically impaired. So the notion that Adam and Eve could have had all existing human alleles is completely wrong.

Agreed, when a mutation isn't neutral, it usually makes you dead or causes such things as cystic fibrosis, sickle cell anemia, Tay-Sachs disease, phenylketonuria and color-blindness, to name a few....

On the other hand, when it's positive, it can provide good immunity to malaria, stronger bones, resistance to arteriosclerosis, immunity to HIV, and so on. As you just learned, natural selection tends to remove the harmful ones and increase the good ones.

The HbS gene is an instructive case, because when one has two HbS alleles one has a debilitating and often fatal disorder. But if one has one HbS allele, one has very good immunity to malaria, which is a debilitating and often fatal disease. In areas where malaria is common, HbS is prevalent, because people who are heterozygous for HbS will have about 3/4 of their children immune to malaria. About 1/4 will have a severe disease that will make them unlikely to live long enough to have children. But those parents without one HbS allele will have most of their children contract malaria with much the same outcome. Hence, HbS is favored where malaria is common, because those with one copy of it will tend to leave more offspring capable of reproducing. Recently, another mutation produced the HbC allele, which is increasing at the expense of HbS. The reason is that homozygotes for HbC, although protected from malaria, are also much more healthy than homozygotes for HbS, and often live productive lives, and reproduce.
 
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Heissonear

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Good science accepts that knowledge is tentative. It will correct itself as new evidence is found. To me, that makes it superior to religious doctrine. Which will rarely, if ever, admit that it is mistaken. I also accept that scientific knowledge will always be incomplete. The deeper our understanding of nature's mechanisms, the more questions we'll encounter. That's not a problem. It's actually what makes science so exciting. There will always be new frontiers to explore. The thrill is in the journey, not the destination.

I think the fundamental difference in religious believers and non-believers is psychological. Believers need an answer to the existential questions of life. And if a naturalistic explanation isn't obvious, or seems unlikely, they'll create a supernatural one. And they'll cling to it. Non-believers--at least like me--don't have a problem with uncertainty. I accept that human knowledge is limited. And I'd much rather inch our way along in understanding the mechanics of how the universe came about, and how it operates, than make up some unverifiable supernatural myth.
One problem, Jayem. Such a way of walking is the idolizing of Science - in life the human mind and heart of turning and exalting Science as what to do in order to know accurately the truth about this life in general and specifics.

In our day mankind has idolized Science. Just look within the Science departments at universities - and their texts. They have the most up to date view of this world around us - what is reality around us and what is not.

People no longer need the Bible nor God Himself in order to know and walk in truth in this life. God and the Bible can be set aside.

But in so doing the age has come where people can walk with an idol in them, and live by such idol, and set the Bible and God aside. In fact this is promoted as the way to live in this world - in idolatry, with Science as central.
 
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