Not that I have any chance of changing your mind, but I do disagree, and I take some comfort in not being alone. Rather than mounting an argument, I'll simply quote from the Foreward of Longo's book, which was written by the Oxford biologist
Denis Noble.
My apologies for the length of it.
During most of the twentieth century experimental and theoretical biologists lived separate lives. As the authors of this book express it, "there was a belief that experimental and theoretical thinking could be decoupled." This was a strange divorce. No other science has experienced such a separation. It is inconceivable that physical experiments could be done without extensive mathematical theory being used to give quantitative and conceptual expression to the ideas that motivate the questions that experimentalists try to answer. It would be impossible for the physicists at the large hadron collider, for example, to search for what we call the Higgs boson without the theoretical background that can make sense of what the Higgs boson could be.
From there he goes on to make several interesting comments about biology. For example, that "[evolution] does not make specific predictions in the way in which the Higgs boson [does] ... evolution is more that of a general framework within which biology is interpreted." Further, while biology does have theories - many theories - they are not subject to any "theoretical construct", they are "not formulated [as theories]", rather they are "presented as fact, a
fait accompli."
He concludes then, that "There is a need for a general theory of biological objects and their dynamics. This book is a major step in achieving that aim."
With respect to this thread and the articles referenced, it was not specifically the work of Strippoli from 2005 that intrigued, but what Sverdlov did with it (and other information) in the second paper in formulating "unsolvable problems" in biology. In the same way, the uncertainty principle of physics is only interesting because of the unsolvable problems it identifies.
I'm not trying to establish some exact equivalency between the two, but as soon as one establishes a principle, it not only tells you what you can do, but what you can't do. That was one of Ana Soto's original complaints about her cancer research. Researcher 1 uses data set 1 to make conclusion 1, which conflicts with what researcher 2 concluded from data set 2. And there was no theory of biology that could mediate the conflict. It was just a battle of numbers with no end in sight.