Can we have absolute knowledge of reality?

[Vene]

I sweat. I breathe. I bleed. I'm aware. Reality is real, if not in this world, then in teh waking world (but I doubt that this is a dream), if you're going to go all "Matrix" world on us.

Have you ever seen an optical illusion? Perception is flawed. As such our view of the world has flaws in it. Along with looking at the world based on past experiences (bias). No Matrix needed.
(But I see what you're getting at)