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Abiogenesis chicken-and-egg problem

Papias

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Put simply the prebiotic soup would have had too high of a PH for the RNA to have survived.

Which prebiotic soup? The one at latitude & longitude 09.3 , 95.8? Or the one 88.8, 23.8? Or all of the thousands of others? The earth is pretty big - a huge range of temperatures, pressures, pH's chemistries, and other local differences would have existed - and only one of them would have had to be conducive.

P.... doesn't give us any verifiable proof of a self organizing RNA viral origin of LUCA,

It doesn't have to - how could such proof exist, when any of a number of chemical routes are possible?


RNA is too complex a molecule to have arisen prebiotically
RNA is inherently unstable
Catalysis is a relatively rare property of long RNA sequences only
The catalytic repertoire of RNA is too limited

These are all beyond the facts we have. Yes, we know that RNA would be not certain to form in a given set of conditions - but more likely in others, so saying "too complex to have arisen" is not something you can know. Yes, RNA is unstable - but so is nearly every molecule in our bodies, and we exist. Yes, longer sequences are needed. Yes, RNA is not as diverse a catalyst as proteins, but we don't need to make a giraffe from scratch - just a self replicator.

It's important to recognize that neither you nor I are experts in this area. Being that those who actually are experts, including thousands of whom are Christians, and who by and large see the RNA world as one of several plausible origins, a few chosen quote and unsupported statements made in ignorance are not very convincing.

you don't have to cite a single creationist to make the argument.

Often, lay readers like yourself, with no scientific training, mistake discussion for weakness - when it is in fact a strength. Yes, various scientists will argue against an idea - just as Einstein argued against quantum mechanics (and was shown to be wrong).

Finding negative statements and pulling them out as quotes hardly helps you. There is a reason why the RNA world discussion is still seen as plausible - and that's because it's predictions keep being shown as true. Life may well have arisen by any of the many other plausible routes, and that's fine.

Here is yet another paper that lays out these plausible routes. It's no surprise that it's from 2012, after many of the problems you mentioned earlier have been solved. It's a lot like me asking if you have absolute proof that your great great great great grandmother was born. Can you show me a birth certificate?

The Origins of the RNA World


Grace and peace,

However, more salient a question than which of the many possible abiotic routes actually was the one which happened, is whether or not we Christians should obsess over that question.

To be clear - I've stated on these fora many times that a perfectly plausible Christian position is that God miraculously poofed the first life form into existence, and that evolution created subsequent species from that - just as a perfectly plausible theistic medicine position is that God miraculously created the first life form, and later life forms can get diseases from germs. In the same way, I could have said in 1900 that God poofed the first reptile into existence, since we didn't have nearly as much evidence of life's evolution from worms to fish at that time, etc.

The upshot is that denying abiogensis does nothing to help one's faith, and worse, shoves God into and ever shrinking God of the Gaps. It fulfills stereotypes that atheists give us of "Christians who oppose research and science", since it is those studies that clarify which routes are more likely than others. It also supports atheists who want people to think that any process that is understood (like pregnancy) is somehow "atheistic", and that God doesn't exist in our regular, understood natural world. It's just plain bad theology.

In Christ-

Papias
 
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mark kennedy

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Which prebiotic soup? The one at latitude & longitude 09.3 , 95.8? Or the one 88.8, 23.8? Or all of the thousands of others? The earth is pretty big - a huge range of temperatures, pressures, pH's chemistries, and other local differences would have existed - and only one of them would have had to be conducive.

What I'm getting is because of the atmosphere and conditions it would have been really hot.

A high-temperature origin of life (80°–110°C) is widely favored (1– 6) because hyperthermophiles, which grow at temperatures between 80° and 110°C, are claimed to be the oldest organisms on the Earth (7), although there are dissenting opinions (8 –11). Added support for this theory comes from atmospheric models depicting an early warm (85°–110°C) Earth (12, 13). Models for an even higher temperature origin include proposals that life arose in the 350°C submarine vents (14 –17) or between 150° and 250°C involving temperature and pH gradients. (The stability of the RNA bases: Implications for the origin of life. PNAS 1998)​

A temperature of say 80 degrees Celsius would be like 179 degrees Fahrenheit. RNA would simply not survive in that environment. There are some well adapted bacteria that can live in extreme temperatures but RNA wouldn't make it and a mean temperature of 60 degrees Fahrenheit would be extremely rare and brief, even if it were conceivable.

It doesn't have to - how could such proof exist, when any of a number of chemical routes are possible?

Yes there are a lot of possible chemical routes and most of them end with the RNA being destroyed and there hasn't been one yet to determine they could self organize into DNA, let alone amino acid sequence, let along viruses or much less proteins.

These are all beyond the facts we have. Yes, we know that RNA would be not certain to form in a given set of conditions - but more likely in others, so saying "too complex to have arisen" is not something you can know. Yes, RNA is unstable - but so is nearly every molecule in our bodies, and we exist. Yes, longer sequences are needed. Yes, RNA is not as diverse a catalyst as proteins, but we don't need to make a giraffe from scratch - just a self replicator.

Oh but it needs so much more then a self-replicator mechanism, it needs a catalytic repertoire beyond that seen in RNA. There is also a need at some point for it to produce a protein which is usually the work of a ribosome or at least an open reading frame. That would require a sequence that included triplet codons and the list goes on.

It's important to recognize that neither you nor I are experts in this area. Being that those who actually are experts, including thousands of whom are Christians, and who by and large see the RNA world as one of several plausible origins, a few chosen quote and unsupported statements made in ignorance are not very convincing.

You don't need to be an expert to understand this, you don't really even need select quotes although they can be found in abundance. You just need a cursory understanding of basic molecular biology and genetics that you were probably exposed to in High School. I cut my teeth on abiogenesis when this place had a number of real world scientists posting regularly and they wouldn't touch it with a ten foot pole. They simply don't have a working model for this 'popular fantasy'.

Often, lay readers like yourself, with no scientific training, mistake discussion for weakness - when it is in fact a strength. Yes, various scientists will argue against an idea - just as Einstein argued against quantum mechanics (and was shown to be wrong).

I don't argue against the work of scientists, I seek it out and argue from it. It's the presuppositional logic of Darwinian evolution I'm at odds with and I've always managed to hold my own when they do manage to discuss the details.

Finding negative statements and pulling them out as quotes hardly helps you. There is a reason why the RNA world discussion is still seen as plausible - and that's because it's predictions keep being shown as true. Life may well have arisen by any of the many other plausible routes, and that's fine.

It doesn't help you to ignore those quote because you find no help in the scientific literature either.

Here is yet another paper that lays out these plausible routes. It's no surprise that it's from 2012, after many of the problems you mentioned earlier have been solved. It's a lot like me asking if you have absolute proof that your great great great great grandmother was born. Can you show me a birth certificate?

The Origins of the RNA World

Oh Papias, I just love your optimism here but did you even read it:

Another Chicken-and-Egg Paradox
The previous discussion has tried mightily to present the most optimistic view possible for the emergence of an RNA replicase ribozyme from a soup of random-sequence polynucleotides. It must be admitted, however, that this model does not appear to be very plausible. The discussion has focused on a straw man: The myth of a small RNA molecule that arises de novo and can replicate efficiently and with high fidelity under plausible prebiotic conditions. Not only is such a notion unrealistic in light of current understanding of prebiotic chemistry ((The Origins of the RNA World. Cold Spring Harb Perspect Biol. 2012)​

You run into this every single time, abiogenesis is a self refuting 'popular fantasy' that has no plausible working model after decades of ill-fated attempts at one.

However, more salient a question than which of the many possible abiotic routes actually was the one which happened, is whether or not we Christians should obsess over that question.

I'm hardly obsessed, it's a pass time, nothing more. There isn't enough here to obsess over.

To be clear - I've stated on these fora many times that a perfectly plausible Christian position is that God miraculously poofed the first life form into existence, and that evolution created subsequent species from that - just as a perfectly plausible theistic medicine position is that God miraculously created the first life form, and later life forms can get diseases from germs. In the same way, I could have said in 1900 that God poofed the first reptile into existence, since we didn't have nearly as much evidence of life's evolution from worms to fish at that time, etc.

It seems perfectly plausible to me that God created life fully formed and it evolved from there. It certainly makes a lot more sense then the fantastic speculation that never seems to deliver on the burden of proof.

The upshot is that denying abiogensis does nothing to help one's faith, and worse, shoves God into and ever shrinking God of the Gaps. It fulfills stereotypes that atheists give us of "Christians who oppose research and science", since it is those studies that clarify which routes are more likely than others. It also supports atheists who want people to think that any process that is understood (like pregnancy) is somehow "atheistic", and that God doesn't exist in our regular, understood natural world. It's just plain bad theology.

First of all I don't think your an atheist because you are convinced of Darwinian evolution as natural history, the thought never entered my mind. What is more I'm enthralled with the scientific research on the subject of origins and I've learned an enormous amount of things from pouring over the work of scientists on the subject matter. I refuse to accept that because I do not subscribe to exclusively naturalistic assumptions I'm somehow at odds with science, I know better and trust me, I've done my due diligence here.

I would just advise you brother and I mean this in the kindest possible way, they are unbending on their categorical rejection of God or miracles across the board. This is an intellectual and philosophical exercise in evidential apologetics and natural theology for me, yielding many a fascinating glimpse into the life sciences and the role of worldviews in philosophies of natural and human history. If you find their arguments and theories convincing I say go in peace I have no problem with you. However, skepticism is highly prized in science and there is no earthly reason a person cannot honestly posit a dissenting view of a philosophy of natural history pitted against anything remotely miraculous. I simply reserve the right to remain unconvinced.

Grace and peace,
Mark
 
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Papias

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A temperature of say 80 degrees Celsius would be like 179 degrees Fahrenheit. RNA would simply not survive in that environment.

Do you have data on that? The decomposition temperature of RNA is no doubt well established, the fact that temperatures like this are discussed suggest that it's higher than this. The fact that DNA is denatured to RNA like strands (which then survive) also suggests greater RNA durability than DNA. Lehninger Principles of Biochemistry


Yes there are a lot of possible chemical routes and most of them end with the RNA being destroyed

You haven't shown that. You've only asserted it without evidence. The fact that these many chemical routes are discussed suggests that the RNA is not destroyed.

Oh but it needs so much more then a self-replicator mechanism, it needs a catalytic repertoire beyond that seen in RNA. There is also a need at some point for it to produce a protein which is usually the work of a ribosome or at least an open reading frame.

The Ribosome *is* RNA. Biophilia: The ribosome as ancient relic

Secondly - yes, self replication is indeed all that is initially needed - because once you have that, natural selection will select the better replicators, and over time that can build up greater functionality.

You don't need to be an expert to understand this, you don't really even need select quotes although they can be found in abundance. You just need a cursory understanding of basic molecular biology and genetics that you were probably exposed to in High School.

Yes, mark, you do need to be an expert to understand this. That's why there are experts who research this stuff. The Dunning-Kruger effect makes it seem to some of us that one can talk out of ignorance, but the bottom line is that doing is like one of us saying that quantum mechanics is all wrong and can't be true to those who use it every day and actually understand it.

It's the presuppositional logic of Darwinian evolution I'm at odds with and I've always managed to hold my own when they do manage to discuss the details.

I've never seen anyone here who actually holds the "presuppositional logic of Darwinian evolution". You simply made that up, and label people (including Christians) who use actual evidence with that term. You've never argued against someone who holds that on these fora - you've only done so in your own mind.

Oh Papias, I just love your optimism here but did you even read it:
Of course I did - and the rest of the paper goes on to work on these problems. This is similar to the often quote-mined Darwin eye quote. You know the one I mean, right?

It seems perfectly plausible to me that God created life fully formed and it evolved from there. It certainly makes a lot more sense then the fantastic speculation that never seems to deliver on the burden of proof.

That's great! Though it does seem at odds with your repeated evolution denial across these fora, especially when it comes to human evolution.

First of all I don't think your an atheist because you are convinced of Darwinian evolution as natural history, the thought never entered my mind. What is more I'm enthralled with the scientific research on the subject of origins and I've learned an enormous amount of things from pouring over the work of scientists on the subject matter.

Cool. I've found this to be a fun source of learning about abiogenesis. I listened to it on my commute.

Origins of Life


I refuse to accept that because I do not subscribe to exclusively naturalistic assumptions I'm somehow at odds with science, I know better and trust me, I've done my due diligence here.

mark, that doesn't make sense. Millions of scientists are Christians. There is no need to be a philosphical naturalist to be a scientist. You can fully accept gravitational theory, and be a Christian who believes in a supernatural God. You can fully accept germ theory, and be a Christian who believes in a supernatural God. You can fully accept evolution, and be a Christian who believes in a supernatural God. You can fully accept atomic theory, and be a Christian who believes in a supernatural God.

A lot of us find it quite odd that you understand that for so many of these, and still apparently get hung up on the fact of evolution.

I would just advise you brother and I mean this in the kindest possible way, they are unbending on their categorical rejection of God or miracles across the board.

Except that they are not "unbending on their categorical rejection of God or miracles across the board". That's simply an alternative fact. Millions of Christians are scientists, including millions who are biologists and fully accept the reality of evolution - including human evolution. You've made up a paranoid delusion in your mind that so many of our sisters and brothers in Christ are atheists, when they aren't.

However, skepticism is highly prized in science and there is no earthly reason a person cannot honestly posit a dissenting view of a philosophy of natural history pitted against anything remotely miraculous. I simply reserve the right to remain unconvinced.
Grace and peace,
Mark

How would you respond if I were to reject the findings of obstetrics, and claim that babies are poofed into existence, fully formed, an hour before birth, and if anyone disagreed with me, I stated that "I simply reserve the right to remain unconvinced."?

Does the standard understanding of the process of pregnancy exclude the fact that God is forming the baby? I personally don't think so. Do you? Do you exclude God from that process?

In Christ -

Papias
 
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mark kennedy

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Do you have data on that? The decomposition temperature of RNA is no doubt well established, the fact that temperatures like this are discussed suggest that it's higher than this. The fact that DNA is denatured to RNA like strands (which then survive) also suggests greater RNA durability than DNA. Lehninger Principles of Biochemistry
RNA is too complicated to have arisen prebiotically, it’s inherently unstable, catalysis is rare or at least severely limited. Add to that the high PH of the primordial oceans at a temperature of at least 180 degrees.
You haven't shown that. You've only asserted it without evidence. The fact that these many chemical routes are discussed suggests that the RNA is not destroyed.

Oh I think what has been presented is more then clear:

The previous discussion has tried mightily to present the most optimistic view possible for the emergence of an RNA replicase ribozyme from a soup of random-sequence polynucleotides. It must be admitted, however, that this model does not appear to be very plausible. The discussion has focused on a straw man: The myth of a small RNA molecule that arises de novo and can replicate efficiently and with high fidelity under plausible prebiotic conditions. Not only is such a notion unrealistic in light of current understanding of prebiotic chemistry (The Origins of the RNA World. Cold Spring Harb Perspect Biol. 2012)​


Thus ribosomal ribinucliec acid. The ribosome isn't a relic it's a complex molecular mechanism:

Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms. It constitutes the predominant material within the ribosome, which is approximately 60% rRNA and 40% protein by weight. (Ribosomal RNA - Wikipedia)
You still don't have a viable path for RNA, let along proteins, let alone a sophisticated combination of RNA and proteins.

Secondly - yes, self replication is indeed all that is initially needed - because once you have that, natural selection will select the better replicators, and over time that can build up greater functionality.

As Darwin said of his warm little pond speculations, oh but what an if:

The RNA World scenario is bad as a scientific hypothesis: it is hardly falsifiable and is extremely difficult to verify due to a great number of holes in the most important parts. To wit, no one has achieved bona fide self-replication of RNA which is the cornerstone of the RNA World. (The RNA world hypothesis: the worst theory of the early evolution of life except for all the others. Biodirect, 2012)​

Yes, mark, you do need to be an expert to understand this. That's why there are experts who research this stuff. The Dunning-Kruger effect makes it seem to some of us that one can talk out of ignorance, but the bottom line is that doing is like one of us saying that quantum mechanics is all wrong and can't be true to those who use it every day and actually understand it.

I don't spend a lot of time on their math or their methods, I'm certainly not interested in non-euclidean subatomic physics. My favorite example is that we are walking through the park one afternoon and decide to have lunch. We stop off at the bakery and buy fresh baked bread and eclairs. Now we may need a baker to make them but certainly don't have to be bakers to eat them.

There are advantages to being a layman, I'm surprised you haven't caught on to this yet.

But in 1987, some Japanese scientists were looking for something in DNA, and they saw this weird group of nucleotides, pieces of DNA. They had no idea what they were doing and what they meant and what their function was. And in a piece they published in The Journal of Bacteriology, the last sentence literally was, and we saw this weird, crazy group of nucleotides, and we have no idea what they're doing there. And that was that. And that was not for a very long time. (New Gene-Editing Techniques Hold the Promise Of Altering The Fundamentals Of Life)​

I strongly suggest you listen to this because it's a ridiculously simple gene with some very powerful capabilities if you hear the rest of the story. Maybe we can't understand a lot of the details but there are a lot of things that can be understood by a layman and one advantage we have, we can jump ahead in the chain.

I've never seen anyone here who actually holds the "presuppositional logic of Darwinian evolution". You simply made that up, and label people (including Christians) who use actual evidence with that term. You've never argued against someone who holds that on these fora - you've only done so in your own mind.

That's simply not true, it's the essence of Darwinian logic. It is universal in it's scope and categorical in it's rejection of divine causation and transcends all natural history and natural phenomenon. Thus a presuppositional logic.

Of course I did - and the rest of the paper goes on to work on these problems. This is similar to the often quote-mined Darwin eye quote. You know the one I mean, right?

Of course I remember it, it's the null hypothesis for Darwinian natural selection.

“If it could be demonstrated that any complex organ existed, which could not possibly have been formed by numerous, successive, slight modifications, my theory would absolutely break down. (Darwin, On the Origin of Species)​

It doesn't even have to be an organ as far as I'm concerned, it could be a cellular organelle.

That's great! Though it does seem at odds with your repeated evolution denial across these fora, especially when it comes to human evolution.

I've spent a lot of time on that and remain unconvinced.

Cool. I've found this to be a fun source of learning about abiogenesis. I listened to it on my commute.

Origins of Life

I'll check it out when I get a chance.

mark, that doesn't make sense. Millions of scientists are Christians. There is no need to be a philosphical naturalist to be a scientist. You can fully accept gravitational theory, and be a Christian who believes in a supernatural God. You can fully accept germ theory, and be a Christian who believes in a supernatural God. You can fully accept evolution, and be a Christian who believes in a supernatural God. You can fully accept atomic theory, and be a Christian who believes in a supernatural God.

It's not the contrary nature of the theory, it's the consummate nature of creation at the point of origin. In the Gospels is the promise of eternal life inextricably linked to the resurrection and the incarnation. I'm not all that concerned about physics, my primary interest is the creation of life and how it relates to the New Testament.

A lot of us find it quite odd that you understand that for so many of these, and still apparently get hung up on the fact of evolution.

Evolution isn't the issue, it's a natural phenomenon not opposed to a miraculous creation 6000 years ago. Evolution can start there and still be unaffected as a naturally occurring phenomenon. The animosity toward anyone suggesting a literal creation week seems excessive since there are millions of Christians who still hold to it. Life comes from life in every living system known to man, the back up problem is the primary source, the unmoved mover. God will always be at the point of origin.

Except that they are not "unbending on their categorical rejection of God or miracles across the board". That's simply an alternative fact. Millions of Christians are scientists, including millions who are biologists and fully accept the reality of evolution - including human evolution. You've made up a paranoid delusion in your mind that so many of our sisters and brothers in Christ are atheists, when they aren't.

I'm not paranoid, I'm actually willing to vet any naturalistic explanation they may choose to dream up. I'm just not going to categorically reject miraculous causation because I've seen first hand what this does to theology.

How would you respond if I were to reject the findings of obstetrics, and claim that babies are poofed into existence, fully formed, an hour before birth, and if anyone disagreed with me, I stated that "I simply reserve the right to remain unconvinced."?

I didn't say God was creating life by divine fiat as a general rule except with regards to original creation. From there procreation, while still well within the purview of divine providence, can remain naturalistic given some exceptions.

Does the standard understanding of the process of pregnancy exclude the fact that God is forming the baby? I personally don't think so. Do you? Do you exclude God from that process?

No I don't exclude God from anything he might decide to involve himself with, however, there's little reason to jump to conclusions. I know God still does miracles but what I get from the Exodus and Jesus and the feeding of the 5,000 is that humans react to miracles the same way they react to everything God does. The believers continue in faith while others turn in their hearts back to Egypt.

Grace and peace,
Mark
 
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mark kennedy

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Most is all it takes when you have dozens that ALL have to form correctly to get anything resembling life.

The simpilest explanation, the RNA world, isn't falsifiable, and a self-replicating RNA has never been demonstrated to be viable in a lab.

The RNA World scenario is bad as a scientific hypothesis: it is hardly falsifiable and is extremely difficult to verify due to a great number of holes in the most important parts. To wit, no one has achieved bona fide self-replication of RNA which is the cornerstone of the RNA World. (The RNA world hypothesis: the worst theory of the early evolution of life except for all the others. Biodirect, 2012)​

This line says it all:

The discussion has focused on a straw man: The myth of a small RNA molecule that arises de novo and can replicate efficiently and with high fidelity under plausible prebiotic conditions.
Sure. So take a couple of million years for it to happen randomly. No problem.

First it has to self-replicate and survive and for it to there would have to be a long stretch or RNA rising de novo (brand new) and fully formed. Otherwise it doesn't matter how many years, it will fail.

Grace and peace,
Mark
 
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Armoured

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First it has to self-replicate and survive and for it to there would have to be a long stretch or RNA rising de novo (brand new) and fully formed. Otherwise it doesn't matter how many years, it will fail.

Grace and peace,
Mark
Where's it written the first self replicator had to be RNA? Or even organic?
 
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mark kennedy

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Where's it written the first self replicator had to be RNA? Or even organic?
No where, proteins first is the second best explanation for the first step but them rising from primordial soup is even more unlikely.
 
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No where, proteins first is the second best explanation for the first step but them rising from primordial soup is even more unlikely.
Did you ever read up on Spiegelman's Monster like I suggested a while back?
 
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mark kennedy

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Did you ever read up on Spiegelman's Monster like I suggested a while back?
That wasn't big news, they've known the behavior of viruses for decades. That's not the same thing as self organizing, 'the Qβ enzyme is what made the RNA molecules'. (Spiegelman's Monster, Wikipedia)
 
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mark kennedy

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Take enough time, it'll happen
In the primordial ocean even if it were possible, which statistically it's not, the extreme heat and acidic environment would destroy it.
 
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In the primordial ocean even if it were possible, which statistically it's not, the extreme heat and acidic environment would destroy it.
Assuming facts not in evidence. There are any number of scenarios that don't require formation in the free environment of the primordial ocean.
 
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mark kennedy

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Assuming facts not in evidence. There are any number of scenarios that don't require formation in the free environment of the primordial ocean.
That's a new one on me, invariably the researchers and theorists deal with the issues of the primordial ocean. One fact that is very much in evidence is the law of biogenesis, life comes from life every single time, Spiegelman's Monster is a prime example.
 
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That's a new one on me, invariably the researchers and theorists deal with the issues of the primordial ocean. One fact that is very much in evidence is the law of biogenesis, life comes from life every single time, Spiegelman's Monster is a prime example.
There's plenty of other theories. Many to do with formation on crystalline surfaces, near black smokers or in evaporated small pools, for example. Maybe expand your pool of information a little.
 
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There's plenty of other theories. Many to do with formation on crystalline surfaces, near black smokers or in evaporated small pools, for example. Maybe expand your pool of information a little.
I've been down that road, it's a blind alley, in the dark with a creepy stranger. Abiogenesis really isn't seeing any major advances and the RNA theory, while compelling, is riddled with holes. Creationists have gotten a lot of mileage our of the probability arguments, there is only one real way to deal with this. Start with a fully functional single cell population and go from there because there is just too much that has to happen otherwise. It's called a priori and there is no other way.
 
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