Any disobedience to God is what we should be concerned with. We are alienated from being in relationship with God with having that still. We would still have salvation with being believers, so we would not have the mark of the beast, if it were already coming. There are things yet to come, ahead of that. We should not remain here, with any of the cities of civilization, it is not meant for the people of God. To have the image of God we should obediently have good stewardship to the earth, God's dominion is not destructive. God hates the destruction from people to this earth, see Revelation 11:18. It will all collapse, see Isaiah 24. This is what the fall of Mystery Babylon is about, and meanwhile so many argue their position like arguing how many angels can dance together on a head of a pin. We have responsibility and we can't just stay here, with doing those things still needed. The one prophesied to be like a beast will come still, with promises to rebuild everything and will deceive many, with not having any godliness in what would be brought, that one should not be followed, and the people of God should not be fooled by him. Staying away from centers of civilization is much much better