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You didn't answer my question. I asked what genes appeared out of nowhere. The paper you quote from is talking about genes that appear our of very similar DNA in our close relatives: "To be a candidate de novo originated gene, in addition to having a potentially translatable open reading frame in the human genome, the gene must have been present, and disrupted (i.e., non-translatable), in both the chimpanzee and orangutan genomes..." These are precisely the kind of genes that can be created by mutation. The creation of truly novel genes out of nothing would be much more dramatic -- and it's what we don't see in genetics.
These are not genes that can be the result of mutations:
The de novo origin of a new protein-coding gene from non-coding DNA is considered to be a very rare occurrence in genomes. Here we identify 60 new protein-coding genes that originated de novo on the human lineage since divergence from the chimpanzee. The functionality of these genes is supported by both transcriptional and proteomic evidence. RNA–seq data indicate that these genes have their highest expression levels in the cerebral cortex and testes, which might suggest that these genes contribute to phenotypic traits that are unique to humans, such as improved cognitive ability. Our results are inconsistent with the traditional view that the de novo origin of new genes is very rare, thus there should be greater appreciation of the importance of the de novo origination of genes.
The highest expression being in the cerebral cortex, that's brain related genes unique to the human lineage. de novo genes are very rare, assuming they just appear out of thin air is baseless.
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