It is a constant struggle for we engineers to run a test where we don't affect the outcome by the way we set up our instrumentation. That physicists even try at the quantum level just boggles my mind ... but then they usually have more money for their toys than I have for solving the world's real problems.
So, in one attempt to measure position, the momentum of the particle is changed. Then, in a second attempt to measure momentum (even if "simultaneous" with the first - and that would be a very difficult thing to do), it is different than during the first measurement. (Or vice versa).
I did wonder for a time if one could make a long series of alternating measurements of a particle: position, then momentum, then position, then momentum, etc. where each measurement was designed to push the particle back and forth between the two measurements like a ping pong. And if, from that, one could ascertain the affect the measurements were having on the particle so that they could be subtracted out - much the same way I deal with white noise. Maybe the question is worth asking, but my general thought is this:
There are a lot of smart people in the world. If there were a way to do it, someone would have devised it by now.
So, I'm going in an opposite direction. What phenomena can we measure with confidence that has derived from the uncertainty principle?