The Standard Model has been very successful so far, but there are lots of things that don't fit.
There is a lot of work being done to resolve these problems. Here is some:
- Empirical
- Neutrino masses
- Matter-antimatter asymmetry
- Gravity
- Dark matter
- Dark energy
- Inflation
- Theoretical
- Sources of neutrino masses -- seesaw mechanism?
- Strong CP violation -- why isn't it observed?
- Higgs-particle instability at around GUT energies
- Elementary-fermion unification at GUT energies
- Gauge unification at GUT energies
There is a lot of work being done to resolve these problems. Here is some:
- Neutrino-oscillation experiments, searches for neutrinoless beta decay
- Nucleon electric-dipole moments
- Proton decay and bound-neutron decay
- Dark-matter direct detection
- Detection of dark-matter annihilation radiation
- Continued search for supersymmetric and other BSM particles at the Large Hadron Collider
- Cosmic Microwave Background: search for evidence of inflation-generated gravitational waves
- Post-Newtonian gravitational effects, the best-known tests of general relativity and similar theories
- ...