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Monkeypox--leveling off

cow451

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What concerns me is that COVID started out as a few isolated cases that everyone thought could and would be contained, then suddenly blew up and spread like wild fire.
COVID is easier to spread, far more than Monkey Pox.
 
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tall73

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https://www.cnbc.com/2022/05/31/bri...keypox-to-abstain-from-sex-as-cases-rise.html

In new guidance released Monday, the U.K. Health Security Agency also recommended that previously infected persons continue to use condoms for a period of eight weeks after the virus has passed, as a precautionary measure.


The U.K. now has the highest monkeypox case count among nonendemic countries, followed by Spain with 120 and Portugal with 96.

As of Monday, there were 555 confirmed and suspected cases of monkeypox in countries outside of Africa, according to Our World in Data.
 
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Skye1300

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The World Health Organisation has warned that it it is not yet known whether it will be possible to contain the spread of monkeypox.

Another 11 cases were confirmed in England today, bringing the UK total to 190 since May 7.

And this summer is expected to see still more cases, with health officials warning that transmission in Europe could be ‘amplified’ by big events like festivals.

The European office of the World Health Organisation (WHO) warned that Europe is at the ‘epicentre’ of the ‘largest and most geographically widespread monkeypox outbreak ever reported’ outside of western and central Africa.

Many of the cases in this outbreak have been linked to ‘large events or parties’, with many more of these planned in the coming months, with those with multiple sexual partners particularly at risk.

WHO Europe regional director Dr Hans Henri Kluge said the recent surge has coincided with the lifting of coronavirus pandemic restrictions on international travel and events.

He warned that the potential for further monkeypox cases in Europe and elsewhere over the summer is ‘high’.
WHO Warns It May Not Be Possible To Contain The Spread Of Monkeypox - WorldNewsEra
 
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tall73

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tall73

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upload_2022-6-2_23-3-8.png



700 confirmed cases per Our World In Data
 
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bèlla

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What concerns me is that COVID started out as a few isolated cases that everyone thought could and would be contained, then suddenly blew up and spread like wild fire.

Biological warfare usually works that way.
 
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essentialsaltes

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tall73

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Investigation into monkeypox outbreak in England: technical briefing 1

The current UK monkeypox strain contains 48 single mutations in its genome relative to the 2018 UK monkeypox strain. Twenty-seven of these mutations are silent in that they do not change any of the viral proteins. Twenty-one of the mutations cause changes in viral proteins.

Mutations are classed in our assessment as low, medium and high priority for investigation, based on the known function of the viral proteins. These assessments are based on the effect of full deletion of these proteins from the virus. It is important to qualify that at present we cannot predict the effect of single mutations compared to full protein deletions. There are 2 mutations of low priority:

  • C9L(R48C): Interferon agonist, when deleted the virus replicates worse in the presence of interferon
  • A46L(H221Y): Virulence factor, deletion of gene reduces virus virulence in mice.

There are 4 mutations at medium priority:

  • C23L(S105L): Chemokine binding protein, deletion of this gene from the virus increases disease severity in rabbits
  • C22L(S54F): Tumour necrosis factor (TNF) receptor-like protein – deletion may increase lung pathology in mice
  • C19L(D266N): Ankyrin repeat protein (unknown function-might be host range or virulence)
  • F13L(E353K): Target of antiviral drug tecovirimat. Tecovirimat resistance has been shown to be conferred by a single mutation at F13L(G277C)
There are 3 mutations in one protein which are classed as high priority:
  • B21/B22(D209N, P722S, M1741I): T-cell inhibitor also found in cowpox, camelpox and horsepox, knock-in of this protein into non-virulent cowpox strains increased disease severity and mortality in rats.

Whilst outbreak clade mutations are distributed across the genome, there is a small subset of mutations in proteins that are involved in virus transmission, virulence or interaction with antiviral drugs. Structural modelling is required to assess the impact of the individual mutations on the proteins.
 
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tall73

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CDC issues new guidance on monkeypox symptoms as U.S. cases balloon

The U.S. has reported 72 cases of monkeypox across 18 states in the last month, making it the country's largest monkeypox outbreak ever.

That total has grown significantly since the beginning of June, when just 19 cases were confirmed.


Confirmed and suspected cases as of 6/16/22

United Kingdom 525
Spain 345
Germany 273
Portugal 241
Canada 191
France 125
United States 100
Netherlands 95
Belgium 52
Italy 50
Switzerland 28
Australia 13
United Arab Emirates 13
Ghana 12
Poland 12
Brazil 10
Ireland 10
Sweden 10
Denmark 8
Slovenia 7
Czechia 6
Israel 6
Mexico 6
Uganda 6
Argentina 5
Austria 4
Finland 3
Hungary 3
Iceland 3
Iran 3
Romania 3
French Guiana 2
Greece 2
Latvia 2
Norway 2
Bahamas 1
Bolivia 1
Cayman Islands 1
Ecuador 1
Georgia 1
Haiti 1
Kosovo 1
Luxembourg 1
Malta 1
Morocco 1
Nepal 1
Pakistan 1
Paraguay 1
Slovakia 1
Sudan 1
Uruguay 1
Venezuela 1

Total: 2,193

Monkeypox Tracker-OurWorldInData.org

 
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