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I recommend getting an external USB hard drive. They are inexpensive and easy to find at any store that sells computer parts and electronics. These days 250-500 GB are the norm, and should be more than sufficient to back up typical user data. Some drives may even have software in which you configure what you want to back up, then press a button on the drive and the backup runs.
If you've purchased a brand name computer like Dell or HP, you will want to keep the recovery CD that came with the computer in a safe place (however, some computers now come with a recovery partition on your hard drive that you can boot from if you need to restore your system to factory defaults).
If your PC did come with a recovery CD, it is likely that it came with a drivers/utility CD that you can use to set up the hardware that specifically came with your computer. Keep it safe. If not, you are likely to be able to get all the driver installation files from the manufacturer's website. Usually, it's a matter of entering the make/model of your PC and then specifying what operating system you are running and it will give you all the drivers. Since some computers ship with different parts, you may want to make a note of the make and model of each piece of hardware listed in the device manager. It's a good idea to have these drivers saved someplace on a CD or flash drive.
If you purchased any software that came on a CD, make sure those CDs are all stored in a safe place with the license or activation key that may be required to re-install it.
If you've purchased software that you downloaded directly from a website, copy those install files to the external drive and you can create a text file with the license key. Make sure the file name is descriptive so you know what it is.
If you've lost your license keys, you can download and install Belarc Advisor for free. This utility takes an inventory of your computer, but the most useful information it gives you is all of the keycodes used for each program installed. Print out the results and keep the document safe.
Finally, check your Add/Remove Programs applet in the control panel and make a note of what's installed so you remember what you need to put back.
What else to back up?
I tend to frown on the idea of backing up your entire system. It takes a long time and uses a lot of disk space unnecessarily. If you're going to rebuild your machine, it's best to do it with a clean install, and then put back what you need. So, here is what I back up:
Backup any folders off the root of the C drive that you may have created.
In Windows, each user has their own profile where user data is stored.
Windows XP:
c:\documents and settings\username\
Windows Vista and 7:
c:\users\username\
You'll want to backup the following folders in each user's profile. You may have to unhide your files and folders to see them.
Desktop
My Documents
Favorites (this is for Internet Explorer)
If you use Mozilla Firefox or another non Internet Explorer web browser, open that program and manually export your favorites and/or bookmarks and then back up that file.
If you use Windows XP and Microsoft Outlook for email, you'll want a copy of all the .pst or .ost files located here by default:
C:\Documents and Settings\Username\Local Settings\Application Data\Microsoft\Outlook\
If you use Microsoft Outlook 2003 or 2007 you'll want the .nk2 file (the auto complete dictionary) located here:
C:\Documents and Settings\username\Application Data\Microsoft\Outlook\
In Windows Vista and 7 you'll want to save the following folders for each user:
Contacts
Desktop
Documents
Downloads
Favorites
My Music
My Pictures
My Videos
Saved Games
The Outlook .pst file is located here for Outlook 2003 and 2007:
C:\Users\username\AppData\Local\Microsoft\Outlook
The Outlook .nk2 file is located here:
The location of the nk2 file is C:\Users\username\AppData\Roaming\Microsoft\Outlook
Video games can put saved games in various places on the drive, but usually you can find them in the c:\program files\title\ folder. Check the manual for details.
If you need a VPN (virtual private network) client to connect to your office from home, make sure you have the installation/set up information from your employer's network administrator.
That's pretty much it.
You may consider using the Files and Settings Transfer wizard in Windows XP, but I've seen it miss files on occasion and Windows must be at the same version and service pack for you to be able to import your data.
The Windows 7 equivalent is the "Windows Easy Transfer" program, but I haven't tried it out yet.
I also suggest disconnecting your external USB hard drive before restoring your system; don't want to format your backup by mistake.