Are you telling me that legislators know more science than the scientists themselves do?
Can you tell us why you are discussing this instead of evolution? Why are you trying to distract the discussion away from evolution? Having problems arguing against evolution and need to bash scientists a bit as a distraction?
This isn't about science, it's about
safety and
ethics. Science is not a system of ethics. It's about how much risk people are willing to take.
Can you tell me why scientists need a leash?
Not the scientists, the corporations. And corporations need a leash because of greed. Testing drugs requires money. Corporations like to minimize costs. One way to do that is minimal testing. So legislatures step in to ensure that corporations do not cut corners and put the public at a level of risk people consider unacceptable.
When it comes to pharmaceuticals, this trial-and-error, with we plebeians being the lab rats, is ridiculous.
We are always going to be the lab rats. BTW, why do you think lab rats can substitute for us?
Because evolution is true.
However, because of two things -- both part of evolution -- no amount of animal testing is ever going to ensure that any drug is 100% safe:
1. Individuals vary. What is safe for one individual will not be safe, due to genetic differences, for another individual. We have to decide, outside of science, what constitutes an acceptable level of risk.
2. Descent with
modification. Yes, due to our common ancestor, rats and humans are very similar physiologically. BUT, due to divergence from that common ancestor, there are also differences. So we can test all we want in animals, but humans (or some humans) may have a difference that causes a drug to have severe adverse side effects. Thalidomide is an example. Thalidomide is a racemic mixture of enantiomers (mirror-image molecules with the same molecular formula). One enantiomer is teratogenic in humans. Humans are able to convert the safe enantiomer to the teratogenic one.
This is why we have Phase I and II clinical trials. Both of those are designed to test the
safety of a drug. Its effectiveness is irrelevant in Phase I trials and a distant second in Phase II trials. But both are done on limited numbers of patients. So sometimes, as with Celecoxib, the adverse effects are so rare that they are not statistically detectable in the Phase I and II trials. Only when tens of millions of people take them do we find the 0.0001% that have severe adverse side effects.
What do they know that the scientists themselves don't?
They know less than the scientists about science. But they are the duly elected representatives of the people to decide on what the people will accept in terms of risk. That's their job: decide what risks it is acceptable for the public to be exposed to.
If I was a legislator, and a barrel of scientists came to me and said, "Look! This stuff is safer than drinking water! Let's go! England's doing it. Canada's doing it. All Pangaea except we are doing it!"
I'd probably push for it too.
Actually, as you have shown, it wasn't "a barrel of scientists" that said this. It was the
company that made Thalidomide.
But yes, you make decisions based on the data you have. When you get new data, you change your decision. You have a problem with that?