mark kennedy said:
Those are nonsynonomous, coding base substitutions that change the amino acid seqeuence, fixed in the entire genome. What is more they are gross structural changes. Say what you what you like about the synomomous substitutions but the amino acid sequence in protein coding genes? Obiviously, there are going to be a lot of mutations going on and being fixed in the entire genome, what was the ratio of deleterious effects to benefical ones and don't forget the neutral ones.
Are you
ever going to make a point here? You just keep repeating the same things over and over, as if they were an argument against common descent. If you've got an argument in here, I sure can't see it.
Does the common ancestor model really predict all of that, or does it interprute everything the same.
Yes, it predicts all of that. Some of it requires additional information, e.g. the way that chromosomes line up is required to predict the extra telomere and centromere, but yes, it's all predicted, and all quite straightforward.
Tell me, do you still think that the DNA of humans and chimps are 99% identical are did you have to revise that to, what is it now, 95%?
I never did think human and chimp DNA was 99% identical. I thought it was 99% identical in the (large) fraction of the genome that was shared by the two species. I didn't know how many or how large the indel differences were, because no one did.
Did it predict that 83% of the protein coding genes were different
I've never thought about it. Let's see . . . The average gene is about 1000 base pairs long in its coding sequence. Without selection, we would expect to find an average of 13 differences per gene between human and chimp (based on the genome average of 1.3%). About 2/3rds of coding changes are nonsynymous, so we'd expect about 8 nonsynonymous differences per gene, still ignoring selection. The estimated effect of purifying selection, based on an earlier study in humans, was that 38% of nonsynonymous mutations would survive purifying selection, leaving 3 nonsynonymous changes per gene between humans and chimps. If we assume that selection is uniform across genes (which is isn't) and that all genes are the same size (which they aren't), then the number of nonsynonymous differences will have a Poisson distribution. With a mean of three, that means that 95% of genes should have at least one such difference. That should be something of an overestimate, since small genes and highly conserved genes would have a greater chance of having zero than the average gene -- so finding out that the measured value is 83% doesn't surprise me at all.
In other words, yes, common descent, along with what we already knew before the chimp genome was sequenced, does indeed predict about the observed number of nonsynonymous differences. (The neat thing is that I had no idea what the answer was going to be when I started typing that paragraph -- I calculated as I typed.)
or that there would be 14 gross structural changes?
No, the indel rate wasn't known well enough to make a prediction.
Did it predict that 1 in every 407 nucleotides would be different when lined up side by side?
You mean there's an indel every 407, right? The rate of differences is higher than that. And no, as I said, we couldn't predict the indel rate because it wasn't well enough known in humans yet.
Did it predict that it would require hundreds, if not thousands of mutations in hundreds if not thousands of genes?
Predict that what would require hundreds or thousands of mutations? No one knew then, and no one knows now, how many important functional differences there are between humans and chimps.
Did it predict that relaxed functional constraint could not account for the exponential growth and development of the brain in 2 million years, not 6 million years?
Common descent doesn't make any predictions about what is and what isn't selected -- it just predicts the kind of similarities we expect to see. But yes, everyone already thought that the our increase in brain size was the result of positive selection.
Did it ever account for the level of divergance that has become evident and obvious and offer a demonstrated or directly observed molecular mechanism that accounts for this unprecedented expansion of the human brain from that of an ape?
Mutation and natural selection have been observed for some time now. You already know that. That they are unable to explain the increase in human brain size is a "fact" that you made up, and for which you have not the slightest bit of evidence.
Or did all the evidence, dispite its enormous burden of proof simply interprute the data in such a way as to make it fit into the single common ancestor model?
No. I've tried to get any creationist, anywhere, to explain the observed genetic data based on a creationist approach. They can't. If creationists can't do it, it can't be our stupid, blind prejudice, can it?
Where are all of these predictions that cannot be dismissed as presumptions?
There is nothing at all that you could not dismiss as a presumption. Doing so with any intellectual honesty, however, is a tougher proposition. I gave you a list of predictions of common descent. If you want your hypothesis on independent descent to be taken seriously, you had better start, right now, explaining each of them based on your hypothesis. Because at this point my conclusion still stands: your hypothesis is scientifically bankrupt.
One more thing, where are the subspecies that Darwin predicted where an inevitable by product of evolution? Human beings don't have a subspecies, as a matter of fact we don't speciate the way animals do and we have faced every geological challenge this world has to offer, did the single common ancestor model predict that?
Where did Darwin predict that all species should have subspecies? Common descent certainly doesn't predict that