IWB (inside waist band) holster...on my left (dominant hand) somewhere between my hip and back...doesn't dig into my hip bone or back that way.
...and while it's true that a .22lr could technically kill someone, I'm still a staunch believer that a 9mm round is the minimum for a defensive weapon as anything less runs the risk of not stopping the bad guy.
If you're a professional or have combat experience, then you might be able to pull off a precision shot in a tense/high-pressure situation...for the lion's share of the population, if it ever came to that, nerves are going to be a factor and you'll be lucky just to hit your target anywhere, much less, a vital zone that would be a one-shot-dropper with a smaller round. A shoulder hit with a .380 isn't going to be a finishing move against a determined assailant...as where a .40 or .45...you could basically hit the bad guy anywhere and they're going to re-think their life choices.