Adam and Eve were physically perfect. God made them in His image.
But what about all the people who were born with genetic defects? If we were all made in His image, why don't we all have perfect DNA? Millions of people have defects known to only be caused by flaws in either how an ovum is fertilized or the DNA itself - not anything the mom did wrong while she was pregnant.
The following are some teachings from Catholicism:
355 "God created man in his own image, in the image of God he created him, male and female he created them."218 Man occupies a unique place in creation: (I) he is "in the image of God"; (II) in his own nature he unites the spiritual and material worlds; (III) he is created "male and female"; (IV) God established him in his friendship.
I. "IN THE IMAGE OF GOD"
356 Of all visible creatures only man is "able to know and love his creator".219 He is "the only creature on earth that God has willed for its own sake",220 and he alone is called to share, by knowledge and love, in God's own life. It was for this end that he was created, and this is the fundamental reason for his dignity:
“What made you establish man in so great a dignity? Certainly the incalculable love by which you have looked on your creature in yourself! You are taken with love for her; for by love indeed you created her, by love you have given her a being capable of tasting your eternal Good.”221 Catherine of Siena
357 Being in the image of God the human individual possesses the dignity of a person, who is not just something, but someone. He is capable of self-knowledge, of self-possession and of freely giving himself and entering into communion with other persons. And he is called by grace to a covenant with his Creator, to offer him a response of faith and love that no other creature can give in his stead.
358 God created everything for man,222 but man in turn was created to serve and love God and to offer all creation back to him:
“What is it that is about to be created, that enjoys such honor? It is man that great and wonderful living creature, more precious in the eyes of God than all other creatures! For him the heavens and the earth, the sea and all the rest of creation exist. God attached so much importance to his salvation that he did not spare his own Son for the sake of man. Nor does he ever cease to work, trying every possible means, until he has raised man up to himself and made him sit at his right hand.”223 St. John Chrysostom