It is he who is in the world (God's enemy) who has made himself the enemy of the human by deceiving it in the garden of eden. The humans are not enemies to God, they spend their whole life trying to find that relationship that was broken when they inherited their fallen nature. "Truth" vs "lie" is God vs His enemy, and it is us who decides which one we listen too. The enemy dangles a carrot in our face while God grants our free will. One day we may ask God to tell us the truth and all the lies we believe go "snap" and fall into place. The enemy has no answers that will help us with salvation, Jesus has all those answers and even more.
There is no way you can find God through investigating the universe. When you find God and realise His magnificence, all the knowledge in the universe suddenly appears to be less significant.
So, man is not an enemy of God but, if someone uses their own critical thought to understand something, then they are listening to "the enemy?"
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