All,
I've rarely posted on this forum before, but my friend Rising Tree told me that he'd started a thread that I may be interested in. I'm very interested in biochemistry, and I believe it poses a few problems to the origin of life scenario. I posted this in another forum before, and the discussion following was not a very scientific one, but rather emotional. The problems I address focus mainly on chemical evolution.
Firstly, there is the issue of chirality. Amino acids come in L- and D-forms (left and right handed, respectively) which occur "in nature with roughly equal frequency [Dembski and Kushiner, eds., 2001, p. 109]." This poses a considerable difficulty, because "Only L-amino acids are commonly found in most organisms [Purves
et al. 2001, p. 32]" except in a few cases, such as the "oligopeptides of cell walls [Huber and Wachtershauser 1998]." It is significant to note that "the amino acid products of (abiotic) laboratory syntheses are usually a 50:50 mixture of D and L (a racemic mixture) [Bernstein
et al. 2002]."
Proteins have a very specific structure that is dependent upon its
backbone--the amino acid sequence. About half of the sites along the chain are called active sites, and are quite critical--there are fatal consequences if something is changed [Moreland, ed., 1994, p. 179]. This is because of the protein's primary, secondary, tertiary, and quaternary structure--primary being the backbone. Once a protein is assembled, it folds into a very specific shape (one biology textbook shows that, for a protein made of 100 amino acids using the 20 found in living proteins, 20^100 different proteins are possible [Purves
et al. 2001, p. 38]). This shape is determined by such factors as delta-charges (very weak charges in polar molecules), R-groups that are hydrophobic (they don't like water, so they all get together to squeeze it out), R-groups of different charge, etc. The protein's specific structure is dependent upon the amino acid sequence. A protein's function is completely dependent on its shape (since it binds to other things with an exactly complementary shape to its own).
Now, since its shape is so important,
no D-amino acids can be present, or its function will be destroyed. However, as quoted above, experiments produce a racemic mixture of amino acids--that is, a mixture with an equal amount of each handedness.
Many scientists have tried to solve this problem [e.g., Berstein
et al. 2002; Rikken and Raupach 2000; Huber and Wachtershauser 1998], but none of the scenarios are very convincing [Cohen 1995]. For example, it is said that circularly polarized UV light will destroy one handedness quicker than the other. However, both forms are destroyed, and by the time the mixture is 100% one-handed, there is a very small amount of amino acids left at all. This idea, set forth by Rikken and Raupach [2000], also makes a number of asusmptions: for example, in their model, incoming light must be parallel with magnetic flux lines--something I don't presume is very likely to happen! Additionally, the magnetic field they used was 15 T. This is outrageous! Even
sunspots have a strength of only about 4 T! Other ideas have similar problems.
Once this problem is overcome, there's the problem of getting the amino acids to polymerize (come together) and
stay that way. Dr. Michael J. Behe, a biochemist (author of
Darwin's Black Box), stated the following:
The major problem in hooking amino acids together is that, chemically, it involves the removal of a molecule of water for each amino acid joined to the growing protein chain. Conversely, the presence of water strongly inhibits amino acids from forming proteins. Because water is so abundant on the earth, and because amino acids dissolve readily in water, origin-of-life researchers have been forced to propose unusual scenarios to get around the water problem [Behe 1996, pp. 169-170].
Higher temperatures accelerate this breakdown of polypeptides. However, as noted by Shapiro [1999, p. 4399] while discussing cytosine and chemical evolution, "It has been argued that a cold or frozen condition for early Earth would be more favorable for the origin of life, as it would slow the decomposition rate of cytosine and the other bases. It is not obvious that any advantage would be gained by this, however, as the rate of synthetic [putting
together] reactions would also be slowed on a frozen Earth." So it doesn't much help if the temperature is lowered.
This is a very sketchy overview of the problems encountered in origin-of-life research. The many roadblocks have driven some scientists to conclude that something other than proteins started life out: for example, the 'RNA World Hypothesis', which hold that RNA was the first thing to 'emerge'. This doesn't seem very promising to me either. Gerald F. Joyce [Joyce 2002, p. 215], an authority on this subject, said that "
If the building blocks of RNA were available in the prebiotic environment,
if these combined to form polynucleotides, and
if some of the polynucleotides began to self-replicate, then the RNA world may have emerged as the first form of life on Earth. But based on current knowledge of prebiotic chemistry, this is unlikely to have been the case [emphasis mine]." Many problems with the stability of the RNA bases have been examined, and pose a great problem to the RNA World [Shapiro 1999; Levy and Miller 1998; Larralde
et al. 1995]. A naturalistic origin of life simply doesn't seem too promising at the time being.
References
Behe, Michael J.,
Darwin's Black Box: The Biochemical Challenge to Evolution (New York, NY: Touchstone, 1996).
Bernstein, Max P.,
et al., "Racemic Amino Acids from the Ultraviolet Photolysis of Interstellar Ice Analogues,"
Nature 416(6879):401-403, 28 March 2002.
Cohen, Jon, "Getting All Turned Around Over the Origins of Life on Earth,"
Science 267(5202):1265-1266, 3 March 1995.
Dembski, William A., and James M. Kushiner, editors,
Signs of Intelligence (Grand Rapids, MI: Brazos Press, 2001).
Huber, Claudia, and Gunter Wachtershauser, "Peptides by Activation of Amino Acids with CO on (Ni,Fe)S Surfaces: Implications for the Origin of Life,"
Science 281(5377):670-672, 31 July 1998.
Joyce, Gerald F., "The Antiquity of RNA-Based Evolution,"
Nature 418(6894):214-221, 11 July 2002.
Larralde, Rosa,
et al., "Rates of Decomposition of Ribose and Other Sugars: Implications for Chemical Evolution,"
Proceedings of the National Academy of Sciences USA 92(18):8158-8160, 29 August 1995.
Levy, Matthew, and Stanley L. Miller, "The Stability of the RNA Bases: Implications for the Origin of Life,"
Proceedings of the National Academy of Sciences USA 95(14):7933-7938, 7 July 1998.
Moreland, J.P., editor,
The Creation Hypothesis (Downers Grove, IL: InterVaristy Press, 1994).
Purves, William, K.,
et al., Life: The Science of Biology (Sinauer Associates, Inc., and W.H. Freeman and Company, 2001).
Rikken, G.L.J.A., and E. Raupach, "Enantioselective Magnetochiral Photochemistry,"
Nature 405(6789):932-935, 22 June 2000.
Shapiro, Robert, "Prebiotic Cytosine Synthesis: A Critical Analysis and Implications for the Origin of Life,"
Proceedings of the National Academy of Sciences USA 96(8):4396-4401, 13 April 1999.