ReUsAbLePhEoNiX said:
Stupid question: will it ever be possible to clone historic figures from the past , or is the DNA too damaged to do it, also who knows the status of the Mammoth cloning I heard about a few years ago?
To answer this one has to ask==>What is this clone anyway? Just the TWIN brother or sister of the person whose nucleus was fused with the eggs cell. The only difference here is one of age (naturally occurring identical twins are the same age).
People have this scary sci-fi image of nefarious scientists cloning wicked people to revive their particular "evil de jour". They seem to "think" (I use the word loosely) that just "cloning" the person is all it takes... OHHH! CONTRAIRE!! a person is not just the product of his/her genes, but all of the experiences, memory, and learning that has happened to them. To create a true "clone" of a historical person, like Hitler, one would have to not only have a set of Hitler's genes but also "program" the childs brain with all of Hitlers 'ingrams". The only story that has come even close to what it would take to truly 'replicate" an individual is the story "Boys from Brazil" (yes, you guessed it, it you don't already know). Evil Nazi scientist a (ENS) and ODESSA-like group want to clone Hilter in order to get another shot at the Thousand Year Reich. ENS knows that Hitlers' "ideals" were not in his genes per se, but were also the result of his upbringing, and placed the "baby Hitlers" with families that fit the profile of Hitler's original family (let the "programming" begin!). For those who haven't read the book or seen the excellent movie, I won't say any more.
For those who might say, well what about eugenics (building the better human, whatever, through genetic alteration)? That is so far off that it isn't even funny!!! The reason for this is that the product of a gene, usually a protein, may be involved in more than one cellular pathway, hence performing more than one function. Let me give you a simple example:
There is a gene in cats that is involved in processing pigment. A common mutation in the gene results in a protein that doesn't function well at body temperature, hence the hairs on the cat will only have pigment at the tips of the hair where the body is coolest ("shaded silvers, chinchillas). Now these cats are notorious for their short tempers.... Why? Unfortunately for them, this gene is also involved in the pathway that producing the neurotransmitter, dopamine. They don't have as much of it as their "normal' cousins and a shortage of this NT results in a "short temper". Who would think that a protein involved in a pigment pathway would also be involved in a neurotransmitter pathway!!!
If one tries to alter the function of X gene without knowing exactly and precisely the functions that it performs, the outcome might be unexpected. Molecular biophysicists may have sequenced the human genome, but they don't know what all of those genes do (not by a long chalk!). For instance, we don't have much of a clue about the genes involved in developing intelligence. A would-be eugenicist would be very stupid to try and alter any of them without a COMPLETE understanding of the possible outcomes that might result from such an alteration.
I really hate all the hysteria surrounding "human cloning"!!! It's just plain ignorant (many seem to have ODed on the movies " Frankenstein" and 'GATTACA")
It may be possible to make a "genetic" copy of that mammoth (a twin). The problem is going to be where you get the DNA from because the
chromosomes "age" (Ex. the teleomere wear away). HERE is another site that explains the telomere theory of aging. This is problem the scientists faced when they cloned Dolly. The DNA was "old", in other words the donor DNA reflected the age of the donor
so Dolly was born "aged". As a consequence she died (was euthanized) without living a normal lifespan that one would expect from a normal sheep.
To make an exact copy of say Chopin (to really 'clone " ANOTHER Chopin), you would not only need his DNA, but also be able to "program" the clone with all of Chopin's experiences/memories or that clone would just be an identical twin brother, removed from Chopin (a distinct, unique individual) in time (identical twins are the same "age"). Also remember that a clone of Chopin would also face the same problem as Dolly (the "aged" chromosomes from an adult Chopin). Cloning a historical figure?--> not until these problems (personality transfer, "aged" DNA, etc.) are solved. Such problems may be insoluble, but one doesn't proceed from the mindset that a problem is necessarily insoluble (no assumption up front that these problems are impossible to solve). Does that answer your questions?