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Unsatisfactory Scientific Explanations?

Loudmouth

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first of all, epigenetics is all about genes.
it basically relates to how the environment can switch them on or off.

That isn't how antibiotic resistance in bacteria works.


Mol Microbiol. 1993 Sep;9(6):1239-46.

Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot.

Finken M, Kirschner P, Meier A, Wrede A, Böttger EC.

Multidrug-resistant strains of Mycobacterium tuberculosis have resulted in several recent outbreaks. Recognition of drug resistance is important both for treatment and to prevent further transmission. Here we use molecular biology techniques to study the basis of streptomycin resistance in single and multidrug-resistant M. tuberculosis. We demonstrate that streptomycin resistance is associated with mutations implicated in ribosomal resistance. The mutations found either lead to amino acid changes in ribosomal protein S12 or alter the primary structure of the 16S rRNA. The 16S rRNA region mutated perturbs a pseudoknot structure in a region which has been linked to ribosomal S12 protein.​

Antibiotic resistance is driven by mutations, not epigenetics.
 
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Loudmouth

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keep in mind i'm using common decent in the macro evolutionary sense.
if these genes aren't changed, then the body plans aren't changed either.

Does this mean that you agree that the difference between species is due to mutations?

You are aware, aren't you, that these genes are different in sequence between species?
 
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whois

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This is not difficult to grasp.
it is when you try to put all of this into some kind of straight forward logical explanation.
i'm finding out that genetics is anything but straight forward.
and this is what puzzles me the most.
although i've had no chemistry courses, i can understand how just a modest number of carbons (30 or so), with a smattering of hydrogens can lead to compounds ranging into the hundreds.
throw in some oxygen, and that number increases geometrically.
IOW, i can understand the "complexity" of chemistry.
but genetics?
this stuff almost defies description.
Still waiting for your Kimura quotes or links to show how I've misunderstood his ideas.
i have no idea whether you have or not.
i DO know what one cornell professor has said on the topic, and i sent you a PM on what another author has said on the topic.
 
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Loudmouth

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it is when you try to put all of this into some kind of straight forward logical explanation.
i'm finding out that genetics is anything but straight forward.

I am finding that you simply don't understand genetics, which isn't meant as an insult. Genetics is difficult, and only a tiny percentage of the population really understand it. Your misunderstandings are your own.

and this is what puzzles me the most.
although i've had no chemistry courses, i can understand how just a modest number of carbons (30 or so), with a smattering of hydrogens can lead to compounds ranging into the hundreds.
throw in some oxygen, and that number increases geometrically.
IOW, i can understand the "complexity" of chemistry.
but genetics?
this stuff almost defies description.

And yet geneticists and molecular biologists do describe it.
i DO know what one cornell professor has said on the topic, and i sent you a PM on what another author has said on the topic.

I have found that you latch onto one tiny snippet, pulled out of context, and ignore the rest of science. Not a good way to learn about genetics.
 
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Loudmouth

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apparently.

Then it isn't epigenetics, as you claimed earlier.
let's say they are in a different sequence

They are different in sequence.


Nature. 2005 Sep 1;437(7055):69-87.

Initial sequence of the chimpanzee genome and comparison with the human genome.

Chimpanzee Sequencing and Analysis Consortium.

Abstract

Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution.
http://www.nature.com/nature/journal/v437/n7055/full/nature04072.html

Also, they used whole genome shotgun sequencing, not percentage of hybridization as you tried to assert before.

https://en.wikipedia.org/wiki/Shotgun_sequencing
 
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FrumiousBandersnatch

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But isn't that what some are saying about quantum physics that its the observer that is determining the final effects.
People say a lot of silly things. In physics, an observer is anything that makes a measurement. A measurement is any interaction with the system under consideration. So a particle that interacts with a system is an observer. This must be distinguished from the everyday idea of a conscious observer, which is something else. In quantum theory, this distinction was made clear around 70-80 years ago. The only influence consciousness has on the outcome is in setting up the conditions for the observation, although it's worth bearing in mind that the outcome of the measurement must spread out into the environment, including any conscious observers (so they come to know what happened). This spreading is called decoherence, and delineates the observational boundary between quantum and classical probabilistic behaviour. However, as a consequence, conscious observers will become part of the modified system, which may be relevant to the particular interpretation of the quantum formalism you feel most comfortable with.

In QM, the kind of measurement you make determines the kind of outcome you see, but in a counter-intuitive way (wave-particle duality, etc). An analogy is looking at a cylinder; looked at in one way, it appears to be rectangular; looked at another way, it appears to be circular. But it is neither.
So what is averaged out that we end up seeing is only seen that way because it is us that is determining that.
Not really, no. In everyday life decoherence occurs long before we get to see the results.
What we end up seeing isn't what happens in the lead up. So therefore some come up with the many world idea to address this. In another parallel world someone may end up seeing and experiencing a different end result.
Not quite. The mathematical description (the wave function) of an uncertain quantum system before measurement is as a superposition of states (e.g. for a particle, it could be a superposition of spin up and spin down). These are not just descriptions of two possible spin states it could have (i.e. a measure of our ignorance of it's actual spin), but it really is, in some deeply strange way, actually in both states at once.

When you make a measurement (by some interaction), that superposed state resolves to one observed outcome, (e.g. either spin up or spin down). This has been called 'the collapse of the wave function' because, from the conscious observer's point of view, the wave function now describes a particle that is no longer in superposition. But, importantly, there is no collapse of the wave function in the quantum formalism. The overall wave function (described by Schrodinger's wave equation) evolves continuously; at the point of interaction, it encompasses the interacting (measuring particle), which joins the superposition, then with further interactions with the environment, it spreads out until it encompasses the conscious observers and beyond - they all join the rapidly diverging superposition. The Many Worlds interpretation takes this mathematical description literally, eschews the notion of an arbitrary unexplained wave function 'collapse', and instead, accepts that the conscious observer is now in a superposition of having observed both a spin up result and a spin down result. By the time decoherence has occurred (the superposition has spread into the immediate environment) the superposed states can no longer influence each other, they are effectively totally independent, and in 'separate universes' - so the superposed observers are also effectively in separate universes, one where the outcome was spin up, one where it was spin down.

This is all a somewhat parochial view of wave function evolution, because it's just looking at local aspects of the evolution of the global wave function of the universe in Hilbert space, and one could say that, in a sense, the universe doesn't really 'split' each time this happens, because the superposition was really there all along, but the separate 'leaves' of the universe were otherwise identical.

Check out Sean Carroll's 'Why Many Worlds is Probably Correct' and 'Wrong Objections to Many Worlds'.
They are merely trying to unite things together and the only way to do so is to appeal to these ideas beyond the logical realms.
Appealing to ideas 'beyond the logical realms' is not science. QM behaves predictably, according to logical mathematical rules; they are just strange and unfamiliar rules.
Afterall if we go back to the point of where something comes from nothing and this is where things have to go then it has to have something beyond logic and beyond the classical physics to be able to explain things.
There is no point where something comes from nothing. As Lawrence Krauss says, when physicists talk of something coming from 'nothing', they mean empty spacetime (i.e. with no particles or non-zero fields [apart from the Higgs field]). They don't literally mean nothing as in the absence of anything (because that is just a conceptual abstraction of negation). Empty spacetime is subject to quantum fluctuations, which means virtual particles, and so-on.
Some say that there are some scientists who are speculating about quantum woo and pseudoscience by bringing in these far fetched ideas. But even the mainstream science is more or less coming up with the same sort of speculations. Things like multiverses, hologram worlds, string theory, black holes, worm holes, ect are along the same lines. Yet even prominent scientists are using this type of language.
There's a significant difference between pseudoscience & quantum woo, and multiverses, holographic universe, string theory, black holes, worm holes, etc. The latter are reasoned extrapolations based on the possible implications of the mathematics behind well-tested theories, the former are not.
So even though some are saying that the brain cannot be linked with the quantum world at the moment who knows what we will find in a couple of years time. I think thats why some are speculation that the brain maybe connected to the quantum world because there is a rational. That rational started with the findings of quantum physics with things like the observer effect and that everything has to have started in the quantum world even our brains.
We already know that brains are - like everything else - connected to the quantum world, because they're constructed out of it. We also know that it's possible that they may make use of some interesting quantum optimizations at the neural or sub-neural level - although there's no evidence that this is the case. But we equally know that quantum field theory tells us that there are no particles, fields, or forces that operate at human scales that could mediate mind over matter, or any other paranormal or supernatural phenomena. It's basically electromagnetism or nothing. It's disappointing, I know, but there it is. When you invoke quantum mechanics or any other field of science, you can't choose to accept only the bits you want and reject everything else in favour of wishful thinking.
 
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FrumiousBandersnatch

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it is when you try to put all of this into some kind of straight forward logical explanation.
i'm finding out that genetics is anything but straight forward.
and this is what puzzles me the most.
...
IOW, i can understand the "complexity" of chemistry.
but genetics?
this stuff almost defies description.
The underlying principles are pretty straightforward for someone with reasonable intelligence, such as yourself. As is often the case in science, simple principles can combine to produce complex results, and interaction with the real world adds an additional layer of complication. But the basic principles don't change, the complications are just a distraction. If you keep the basic principles in mind, you should be able to see how their effects are just modulated by those complications, not changed in any fundamental ways.
i have no idea whether you have or not.
IOC. When I contradicted your assertions about the implications of Kimura's work, you came back with more of the same assertions, implicitly contradicting my criticism. I assumed you felt you had some good reason to reject what I said.
i DO know what one cornell professor has said on the topic, and i sent you a PM on what another author has said on the topic.
Which was quite reasonable, but didn't seem to support the interpretation you put on it.

Incidentally, I generally make a point of not discussing topics via PM. I'd rather everyone is able see discussions relevant to the thread, and reserve PMs for other matters. Just my preference.
 
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keep in mind i'm using common decent in the macro evolutionary sense.
if these genes aren't changed, then the body plans aren't changed either.
science has already stated they can trace these genes through millennia.
some of them all the way back to bacteria.
this does not imply a changing body plan, in fact it implies the exact opposite.

at the very least it is further proof that macro evolution is not accumulating micro evolution.
it certainly seems to support what eldridge says of the record.
Thats actually part of it. Starting with a simple eukaryote, we still see all those membrane bound organelles in eukaryotic even today. Fast forward to vertebrates. They still all have internal skeletons, bilateral symmetry, etc. Each successive change is expounding on the body plan present, not replacing it.
 
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whois

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frumious,
i again want to commend you on your posting style.
you are certainly one of the friendliest posters here.

The underlying principles are pretty straightforward for someone with reasonable intelligence, such as yourself.
yes, i understand the principles.
unfortunately, a lot of what i'm finding doesn't support those principles.
as soon as i start laying out these findings, on of two things happen:
i'm accused of being a creationist or i'm accused of misrepresentation.
then the ambiguous explanations start.
i can think of two episodes of this off the top of my head.
first involves the following link:
evolutionlist.blogspot.com/2009/11/modern-synthesis-is-dead-long-live.html
the second involves the NY times upload.
there of course others.
As is often the case in science, simple principles can combine to produce complex results, and interaction with the real world adds an additional layer of complication. But the basic principles don't change, the complications are just a distraction. If you keep the basic principles in mind, you should be able to see how their effects are just modulated by those complications, not changed in any fundamental ways.
i'm perfectly aware of this.
there aren't very many examples of a complex machine that cannot be explained by examining its component parts.
a very good example of this is the saturn 5 rocket.
i couldn't come up with a transfer orbit equation if my life depended on it, but yet the individual components of that rocket are easily explainable and understood by almost everyone.
IOW, the closer you look, the simpler it becomes.
this is not the case with genetics.
the simplest is the overall paradigm and it becomes increasingly complex the closer you look at it.
one possible reason for this, is that science is trying to make the evidence fit the theory, instead of formulating the theory to fit the evidence.
i can understand why this would be in regards to evolution.
first and foremost is, evolution just makes sense, logical sense.
second is, theories do not become accepted just because a scientist somewhere provides solid evidence for it.
trust me, i understand ALL of this type of stuff (outside genetics)
IOC. When I contradicted your assertions about the implications of Kimura's work, you came back with more of the same assertions, implicitly contradicting my criticism. I assumed you felt you had some good reason to reject what I said.
Which was quite reasonable, but didn't seem to support the interpretation you put on it.
see, this is the type of "misrepresentation" i mentioned earlier.
i did not interpret my source, i presented it to you VEBATUM.
next comes the amgiguities i mentioned.
you went into some type of phenotype vs DNA explanation when the source mentioned no such thing.
as a matter of fact the source specifically mentioned "vast number of ORGANISMS"
the only ambiguity here is, what is meant by "vast number of organisms".
it's my impression that the "vast number of organisms" on the planet are single celled lifeforms.
but you never mentioned this.
this is just another example of the "closer you look the more complex it gets" statement i made earlier.
and we will NEVER arrive at a coherent understanding when such ambiguities exist.
also, you cannot possibly say this is my fault.
Incidentally, I generally make a point of not discussing topics via PM. I'd rather everyone is able see discussions relevant to the thread, and reserve PMs for other matters. Just my preference.
i stated my reason for the PM in the PM itself.
and yes, i agree wholehearedly with you on this.
unfortunately, there are forces at work here that are bigger than both of us.
 
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FrumiousBandersnatch

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yes, i understand the principles.
unfortunately, a lot of what i'm finding doesn't support those principles.
That's not the impression your posts give. You keep posting about how the modern synthesis is obsolete as if this somehow invalidates common descent through evolution by natural selection. It doesn't. Maybe you don't intend to give this impression, but if so, your intent is obscure.
see, this is the type of "misrepresentation" i mentioned earlier.
i did not interpret my source, i presented it to you VEBATUM.
I apologise if I've misrepresented you; I assumed you posted that source because you thought it supported your interpretation of recent discoveries in genetics. If that isn't the case, I'm at a loss why you posted it at all.
...you went into some type of phenotype vs DNA explanation when the source mentioned no such thing.
I was trying to explain the wider context within which that source applied. I'm sorry you weren't able to follow it.
...as a matter of fact the source specifically mentioned "vast number of ORGANISMS"
the only ambiguity here is, what is meant by "vast number of organisms".
it's my impression that the "vast number of organisms" on the planet are single celled lifeforms.
but you never mentioned this.
Everyone with a basic knowledge of biology will know that the vast majority of organisms on Earth are single celled. But as for the particular quote you mention, I can't really comment without the context, and I don't see it in the recent sources you've posted - perhaps you could remind me which one it is?
this is just another example of the "closer you look the more complex it gets" statement i made earlier.
and we will NEVER arrive at a coherent understanding when such ambiguities exist.
I have to disagree; as I said earlier, if you have a grasp of the basic principles, a little thought should allow you to see how the complexities modulate their effects. But it's hard to make a specific response to a vague complaint of 'ambiguities'.

The puzzle for me is that in one post you bemoan the complexity of genetics and imply you have trouble understanding it:
"i can understand the "complexity" of chemistry.
but genetics?
this stuff almost defies description.
"
And in the next post, you claim that you do understand it. Yet your posts repeatedly make assertions that belie this.
also, you cannot possibly say this is my fault.
I wouldn't dream of doing so - although, frankly, I can't see who else's it could be...
 
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whois

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That's not the impression your posts give. You keep posting about how the modern synthesis is obsolete as if this somehow invalidates common descent through evolution by natural selection. It doesn't. Maybe you don't intend to give this impression, but if so, your intent is obscure.
this is another thing about this debate that just bugs me no end.
you keep saying "your posts" or "you say", and you are by far not the only person that does this.
I AM NOT SAYING THIS STUFF, MY SOURCES ARE SAYING IT.
I apologise if I've misrepresented you; I assumed you posted that source because you thought it supported your interpretation of recent discoveries in genetics. If that isn't the case, I'm at a loss why you posted it at all.
i posted it because of what it said, and let's take a few quotes from it:
But just as the comparative biologists of the late 19th Century could study anatomy and physiology based on a simple Darwinian foundation, so did many mid-20th Century developmental and cell biologists implicitly build their research on assumptions underwritten by the Modern Synthesis: hard inheritance, no orthogenetic "direction" to evolution, adaptation by natural selection, and so on.
www.ncbi.nlm.nih.gov/pmc/articles/PMC2222615/
take careful note of the "adaptation by natural selection".
now this:
Furthermore, it became apparent in the last decades of the 20th Century that DNA sequences often evolved in ways that reduced the fitness of the organisms that bore them.
-ibid.
can you honestly say that natural selection is the primary driver of evolution?
from the source:
. . . many important assumptions of 20th Century biology have been abandoned.
-ibid.
this particular quote is interesting in that it specifically states that the tenents of the modern synthesis are ASSUMPTIONS.
another thing is, it says what we thought we knew about evolution is wrong.
what exactly does this mean in regards to those that continue to toe the party line like these assumptions are still valid, when they aren't.

the point i'm making here is, evolution is not what the modern synthesis says it is
 
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FrumiousBandersnatch

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this is another thing about this debate that just bugs me no end.
you keep saying "your posts" or "you say", and you are by far not the only person that does this.
I AM NOT SAYING THIS STUFF, MY SOURCES ARE SAYING IT.
Well I was referring to the content you've posted in your own words rather than the quotes or links you've posted. If you want to distance yourself from the sources you've quoted or linked, that's fine, but in that case, one wonders why you quote or post them. But it seems reasonable to take the rest of your posts - the parts apparently written in your own words - as expressions of your views; else why post at all?
... it became apparent in the last decades of the 20th Century that DNA sequences often evolved in ways that reduced the fitness of the organisms that bore them.
What's the novelty there? Fitness is almost entirely contextual. You can be the fittest mollusc in the pool until it dries out, or a new predator appears.
can you honestly say that natural selection is the primary driver of evolution?
Phenotypic evolution (species and so-on)? Sure - have you a better explanation?
the point i'm making here is, evolution is not what the modern synthesis says it is
Yes, we know; we've discovered there's a lot more to it than was thought. And Newtonian mechanics turned out to be an approximation... Times change, science moves on.

Are you sure you don't have a more interesting or challenging point to make?
 
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whois

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Are you sure you don't have a more interesting or challenging point to make?
other than to state, as numerous other scientists have stated, the modern synthesis as you know it is dead.

"We should be equally clear that, in arguing for the necessity of this intellectual transformation, we do not think that those who based their research on the Modern Synthesis were "bad scientists" and those who now abandon it are "good scientists." We are simply offering an overview of how a large number of us have changed our thinking, our biological Weltanschauung."
-ibid.

of course, abandoning something definitely implies all is well.

and yes, i certainly have other issues i can raise in regards to evolution.
the possibility that changes do not accumulate at all is one of them.
 
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FrumiousBandersnatch

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...of course, abandoning something definitely implies all is well.
Not so much 'abandoned' as buried under new growth.
and yes, i certainly have other issues i can raise in regards to evolution.
the possibility that changes do not accumulate at all is one of them.
Taken literally, that would mean each change undoes the preceding one...
 
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whois

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Yes, we know; we've discovered there's a lot more to it than was thought. And Newtonian mechanics turned out to be an approximation... Times change, science moves on.
there is a major difference here that you seem to be glossing over.
for example:
what are the many important assumptions of newtonian physics that were abandoned?

in regards to the modern synthesis, one of those key assumptions is that evolution is driven by natural selection.
natural selection simply does not play a central role in evolution.
the evolution of decreasing fitness proves it.
the above seems to throw a monkey wrench in the adaptive assumption of the modern synthesis.
what elgridge said of the record and subsequent adoption of PE smashes the gradualistic paradigm of evolution.
as a matter of fact, at least one scientist has stated "We would not have predicted stasis from population genetics, but I am now convinced from what the paleontologists say that small changes do not accumulate."
do you realize what it takes for a scientist to make such a remark?

although some would like you to think this is merely an extension of the synthesis, it appears to be more than that.
there are many that say it needs a rethink, and quite a few more that says it needs rewritten.
for example, a dialog with noble:
reporter: My understanding is that you are now calling for the modern synthesis to be replaced.
noble: I would say that it needs replacing. Yes.
www.huffingtonpost.com/suzan-mazur/replace-the-modern-sythes_b_5284211.html

the above piece makes it clear that noble is not thinking about a mere extension, because the founding fathers of the modern synthesis never intended some of the things we are currently finding.
for example:
What we are now discovering is that there are mechanisms by which some acquired characteristics can be inherited, and inherited robustly. So it's a bit odd to describe adding something like that to the synthesis ( i.e., extending the synthesis). A more honest statement is that the synthesis needs to be replaced.
. . .
So my argument for saying this is a matter of replacement rather than extension is simply that it was a direct intention of those who formulated the modern synthesis to exclude the inheritance of acquired characteristics.
-ibid.

lynn margulis has this to say:
[W]hat Haldane, Fisher, Sewell Wright, Hardy, Weinberg et al. did was invent.... The anglophone tradition was taught. I was taught, and so were my contemporaries, and so were the younger scientists. Evolution was defined as "changes in gene frequencies in natural populations." The accumulation of genetic mutations was touted to be enough to change one species to another.... No, it wasn't dishonesty. I think it was wish fulfillment and social momentum. Assumptions, made but not verified, were taught as fact.

noble responds: I would certainly go along with the view that gradual mutation followed by selection has not, as a matter of fact, been demonstrated to be necessarily a cause of speciation.
-ibid.

noble present the oft told tail of the ring warbler as so called proof of gradual accumulation and concludes:
Regarding wish fulfillment, what I find is that the modern synthesists tend to quote such ring warbler examples as though it is obvious that they must have occurred by gradual mutation followed by selection, when it isn't certain that that can be the mechanism if other mechanisms exist. You have to prove it. So I go along with the view that there has been no really clear proof that speciation occurred via gradual mutation followed by selection.
 
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FrumiousBandersnatch

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there is a major difference here that you seem to be glossing over.
for example:
what are the many important assumptions of newtonian physics that were abandoned?
Ooh, just off the top of my head, what about absolute space, absolute time, additive velocities, absolute simultaneity? There are probably others to do with matter & energy. So just the fundamentals of matter, space & time... it's still a good approximation, though. Probably more basic fundamentals were abandoned there than in the extension of the modern synthesis - not that it matters.
in regards to the modern synthesis, one of those key assumptions is that evolution is driven by natural selection.
natural selection simply does not play a central role in evolution.
the evolution of decreasing fitness proves it.
I don't see how. Perhaps if you gave some real world examples, it would be clearer.
..as a matter of fact, at least one scientist has stated "We would not have predicted stasis from population genetics, but I am now convinced from what the paleontologists say that small changes do not accumulate."
do you realize what it takes for a scientist to make such a remark?
I'd like to see the quote in context, but taken out of context, it's absurd. Even the 'evolution of decreasing fitness' implies the accumulation of changes... it's in the nature of changes, large and small, to accumulate; everything around us is the result of accumulations of changes.
...What we are now discovering is that there are mechanisms by which some acquired characteristics can be inherited, and inherited robustly. So it's a bit odd to describe adding something like that to the synthesis ( i.e., extending the synthesis). A more honest statement is that the synthesis needs to be replaced.
You seem to have a particular antipathy to the modern synthesis; it's just another theory being replaced, abandoned, subsumed, extended, whatever, in the light of new discoveries. Why the fuss?
So my argument for saying this is a matter of replacement rather than extension is simply that it was a direct intention of those who formulated the modern synthesis to exclude the inheritance of acquired characteristics.
Do you have evidence for that? I'm skeptical; isn't it more likely that they had no evidence for it, so they didn't address it? suggesting that the thousands of contributors over so many decades had that 'direct intention' in common, sounds a bit like a conspiracy theory...
lynn margulis has this to say: ...
noble responds: ...
It's true that Margulis did some excellent work on endosymbiosis, but was known (and made a point of it) as rather a scientific renegade - which is fine, controversy is stimulating, but doesn't make her infallible. And Noble was an excellent physiologist, but it's worth seeing contrary opinions on evolution. And what is necessarily the case and what is generally the case, can be, and often are, different.
Regarding wish fulfillment, what I find is that the modern synthesists tend to quote such ring warbler examples as though it is obvious that they must have occurred by gradual mutation followed by selection, when it isn't certain that that can be the mechanism if other mechanisms exist. You have to prove it. So I go along with the view that there has been no really clear proof that speciation occurred via gradual mutation followed by selection.
And did he present the other mechanisms and prove they were better at explaining it than natural selection of heritable variation? Do tell.
 
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whois

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Probably more basic fundamentals were abandoned there than in the extension of the modern synthesis - not that it matters.
some have said the same about the emerging biology.
it's a more radical change from the modern synthesis, than than the modern synthesis was from darwinism.
I don't see how. Perhaps if you gave some real world examples, it would be clearer.
my sources do not give any examples, unless they are in the references.
I'd like to see the quote in context, but taken out of context, it's absurd. Even the 'evolution of decreasing fitness' implies the accumulation of changes... it's in the nature of changes, large and small, to accumulate; everything around us is the result of accumulations of changes.
you can read about it here, but it's behind a paywall:
Science, vol. 210 no. 4472 pp: 883-887
as for "accumulating change", endosymbiosis can hardly be called an accumulating change.
You seem to have a particular antipathy to the modern synthesis; it's just another theory being replaced, abandoned, subsumed, extended, whatever, in the light of new discoveries. Why the fuss?
of course i do, it would be irrelevant to have a "particular apathy" to darwinism wouldn't it?
why the fuss?
the reason is simple, and i'm surprised it has escaped you.
surely you would want people to know the truth about evolution, right?
so, with that in mind, what exactly IS the truth?
Do you have evidence for that? I'm skeptical; isn't it more likely that they had no evidence for it, so they didn't address it?
you need to ask noble, he is the one that said it.
"So my argument for saying this is a matter of replacement rather than extension is simply that it was a direct intention of those who formulated the modern synthesis to exclude the inheritance of acquired characteristics."
-ibid.
It's true that Margulis did some excellent work on endosymbiosis, but was known (and made a point of it) as rather a scientific renegade - which is fine, controversy is stimulating, but doesn't make her infallible.
yes, i'm sure she was.
do you have any evidence that demonstrates this renegade angle?
And Noble was an excellent physiologist, but it's worth seeing contrary opinions on evolution. And what is necessarily the case and what is generally the case, can be, and often are, different.
noble is but one scientist amongst many that is calling for this transformation.
And did he present the other mechanisms and prove they were better at explaining it than natural selection of heritable variation? Do tell.
the problem here is, i'm not in a position to call noble a liar.
i am presenting my evidence, but you do not seem to be addressing it very well with data.
like noble said, with all the processes of evolution, you need to prove which one is responsible, not assume something because theory requires it.
 
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