After weeks of debate one point of contention seems irrefutable. The mutation rate for chimpanzee and humans, particularly with regards to brain evolution, is impossible to reconcile to modern genomics. I have discussed this for weeks and even had the rare opportunity to discuss the Initial Sequence of the Chimpanzee Genome with one of the authors. This is exciting research but for whatever reason, it gets almost no attention in this forum. I think that is a shame. The biggest problem with apes evolving into human beings is the human brain tripled in size and developed increased density and funtion. I have yet to see a resonable explanation for how this is even possible and yet it must be presumed or you are not being scientific, I'm not buying it.
I bring you yet another renunciation of the much celebrated, never demonstrated, often pontificated, single common ancestor model...but seriously folks. Let us ponder the the most signifigant questions confronting the single common ancestor model in our day. What makes us human? (
Nature 437, 69-87 ) What is the genetic basis for the threefold expansion of the human brain in 2 1/2 million years?(
Genetics, Vol. 165, 2063-2070) What is the genetic and evolutionary background of phenotypic traits that set humans apart from our closest evolutionary relatives, the chimpanzees?(
Genome Research 14:1462-1473)
One of the problems with the evolutionary expansion of the human brain from that of an ape is the size, weight and complexity. The human brian would have had to triple in size, starting 2 1/2 million years ago and ending 200 to 400 thousand years ago. The brain weight would have had to grow by 250% while the body only grows by 20%. The average brain weight would have to go from 400-450g, 2 1/2 MY ago to 13501450 g 0.20.4 MY.
"It is generally believed that the brain expansion set the stage for the emergence of human language and other high-order cognitive functions and that it was caused by adaptive selection (DECAN 1992 ), yet the genetic basis of the expansion remains elusive."
Evolution of the Human ASPM Gene, a Major Determinant of Brain Size, Genetics, Vol. 165, 2063-2070, December 2003
Jianzhi Zhang tried to determine if positive selection of amino acid substitutions that left the reading frame open are detectable in the ASPM gene. He instead found strong purifying selection and concluded that the postive selection of the ASPM gene took place time between 67 and 0.1 MY ago (0.5 x 10,000 generations x 20 years/generation). Researchers have determined that the gene is still evolving but I wonder how a congenital developmental defect characterized by severely reduced brain size could be an advantage.
Overall genetic differences create a problem since the size of the genetic differences is growing. Type 'DNA simularities between humans and chimpanzees' into a google search engine and you will find estimates close to 99%. Growing evidence has determined that these estimates are just plain wrong. The divergance has been found to include indels of considerable length, in the comparision of the Chimpanzee Chromosome 22 and its counterpart Human Chromosome 21 found that 83% of chimpanzee chromosome 22 proteins are different from their human counterparts.
"Sakaki said their analysis found about 68,000 insertions or deletions. "That is almost one insertion/deletion every 470 bases," he said. In addition, a small proportion of genes showed a relatively higher rate of evolution than most other genes. "We haven't known what proportion of the genes shows adaptive evolution. This study shows it to be about 2 to 3%," he said."
Chimps are not like humans Whole-chromosome comparison reveals much greater genetic differences than expected
More recently, the Chimpanzee Genome project published their highly anticipated
Initial sequence of the chimpanzee genome and comparison with the human genome, Nature 437, 69-87 (1 September 2005). What they found was the the differences between the chimpanzee and human genomes have a 35 million nucleotide difference with five million insertion/deletion events, and various chromosomal rearrangements. This would include a 3 million bp divergance in the function part of the genome effecting vital functions.Even by conservative estimates the fixation of single base substitutions, insertions, deletions and polymorphisms (including chromosomal rearrangements) would have to average anywhere from 3 to 7 bp differences, fixed in the respective geneomes, per year for humans to evolve from apes. The most important of these would be the human brain with the most important changes occuring in the cerebral cortex.
Consumed with incredulity I started to wonder how the genes effecting brian function were related to the presumed common ancestor of Man and Chimpanzee. What I found was astonishing and I don't mean the differences between chimpanzees and humans, which are considerable. The differences within their respective species and, even more supprising, from one individule to another are far larger then I realized. In fact, 22% of the genes that showed differences between humans and chimpanzees where due to differences between individules within their respective species.
What follows is from
Regional Patterns of Gene Expression in Human and Chimpanzee Brains . Apparently the transcriptomes differ more between individules then between regions. In comparing human and chimpanzee genes differ by 10% in at least one region with the majority being shared in all others. I will make every attemp not to exaggerate the differences nor dismiss the simularities. I, like most people interested in the theory of evolution, am interested in the genetic basis of evolution.
"The draft sequence of the chimpanzee genome will allow most nucleotide differences between the two species to be listed. However, to interpret these differences in terms of function, an important step is to know how gene expression has changed between humans and chimpanzees. Because several important phenotypic differences that distinguish humans and apes are associated with cerebral activity, it is of particular interest to investigate the gene expression patterns in brains of humans and chimpanzees."
Figure 1 Location of areas sampled from the human cerebral cortex.
The cerebral cortex in involved in many complex brain functions including memory, attention, perceptual awareness, "thinking", language and consciousness.
"In the cerebral cortex, the biggest difference in gene expression is between the primary visual cortex and the anterior cingulate cortex in both humans and chimpanzees, where 193 and 227 genes differ in expression in humans and chimpanzees, respectively."
The primary visual cortex has been observed to have distinct differences between chimpanzees and other primates considered to be related to humans. The human nonphosphorylated neurofilaments (NPNF) is denser with embedded cell bodies, were intermingled with lightly stained territories, giving the layer a mesh-like appearance. (Cerebral Cortex, Vol. 12, No. 7, 671-691, July 2002)
In other regions the differences are close to nonexistant.
"Only one gene out of the 4998 genes with detectable expression differs in expression between Broca's area and the left prefrontal cortex in all three humans analyzed and none in chimpanzees."
Figure 3 Number of genes exhibiting expression patterns specific to brain regions in humans and chimpanzees.
In all the differences amount to:
"406 differentially expressed genes for which the chimpanzee DNA sequence is known, 207 are more highly expressed in humans and 199 in chimpanzees."
What is the explanation that is most often used to explain the level of divergance in genes affecting the brain? Welcome to the wonderfull world of duplications. Chromosomes 1, 2, 4, 5, 9, 12, 15, 16, 17, and 18, are known sites of signifigant differences between chimpanzees and humans. Instead of differences modern researchers simply insert the word selection instead of admitting the coding regions have distict structural differences. In the conclusion they assume that these chromosomal rearrangements led to speciation because they lead to lower recombination in the heterokaryotypes.
"Gene expression differences between humans and chimpanzees are furthermore associated with regions of segmental duplications in the human genome
Table 5 . This association is seen for genes that show higher expression levels in humans than in chimpanzees, whereas there is no statistically significant association with genes that are more highly expressed in chimpanzees."
They are still propagating the idea that we are 99% identical to the chimpanzee and this is not only wrong, it is shamefull. If there is going to be a substantive discussion of what shapes the diversity alleles in populations over time the actual differences should be accounted for. Here is a fairly typical statement of fact that has been proven wrong conclusivly. Submitted as a post script for your general interest and amusement.
"Humans are 99.9% alike genetically, and that 0.1% makes all the difference in terms of appearance, personality, and susceptibility to disease. That 0.1% promises to shed light on the evolutionary forces that control genetic variation as well as the genetic origins of human disease."
A DNA Recombination Hotspot in Humans Is Missing in Chimps
We are talking about what makes us human and the genetic basis of our supposed shared common ancestory with chimpanzees. Will they and those who made these erroneous statement in the past now revise their statements? If they do the recombination rate and segmental gene duplications just got harder to demonstrate, four to five times harder in fact. In the case of human genes expressed in the brain as compared to the chimpanzee its more like ten.
Looking genome wide there are about 35 million single nucleotide that are different plus about 5 million indels (insertion/deletion=indel). I have stretched this all the way to ten million years and did some really basic math. 40 million nucleotide differences accumulated over a ten million year period. 40,000,000 divided by 10,000,000 gives you 4 nucleotides established genome wide per year for ten million years. This simply does not happen in nature and something infinitly more important. Evolutionists have been telling us that we are virtually identical to apes and the fact is that we are vastly different. For every 400 nucleotides in the human genome as compared to the chimpanzee genome there is one difference by even the most conservative estimate.
The real question for evolutionary biology is did they accumulate 4 nucleotides a year are have sudden spikes in the mutation rate? Obviously mainstream science has abandoned the concept of apes and humans being fully formed 6-10 thousand years ago. So we can just forget about the idea being entertained by evolutionary biologists. So as the research continues when they are looking for the genetic basis for such a dramatic change in an evolving genome the question arises, how did they get there.
Do me a favor, don't just say evolution. Evolution is a theory that investigates the change of alleles in populations over time. There is no such thing as evolution as a natural cause of adaptation, evolution is the effect. In other words evolution is the change being observed, not the reason that the change happened. The same thing with natural selection, until a change is actually made natural selection cannot act. When the change produces a beneficial trait then it is preserved simply because it inhances survivablity.
The first question is what makes us human and remember saying goddidit is not an option, that would be psuedo science. Don't get me wrong I am a young earth creationist and I think evolutionary biology is chasing the wind here, I just want to know what the genetic basis is for human evolution. I warn you though, if you say evolution or natural selection you are wrong, those are methodologies and effects respectivly. Call it psuedo science or an argument from incredulity if you will, my explanation for these differences is that 'In the Begining God'.
Grace and peace,
Mark