The telomeres don't ensure perfect cellular reproduction, they basically count down to the end of the cell lineage, generation by generation. There are a host of other factors involved in ageing.
The telomeres don't ensure perfect cellular reproduction, they basically count down to the end of the cell lineage, generation by generation. There are a host of other factors involved in ageing.
No, I don't how exactly how they avoid ageing, and yes, they are remarkable in that respect.
They appear to have low mutation rates, unusually active DNA repair and defective protein disposal mechanisms, highly accurate ribosome translation, produce high levels of protein chaperones (that help maintain protein folding structure), and various other advantages - including tight regulation of telomerase expression, which protects the telomeres... All of which - and probably more - prolong the lives of their cells and cell lines.
As I said, there's more to it than keeping telomeres from fraying.