Thanks. Just one is enough for me to justify my vote. So if there is one that hits those two conditions it works.
I can do all of them pretty succinctly and since I reject your framing of what would constitute evidence, I shall present each of them as evidence for evolution (again, succinctly).
- Hoxd12 and Hoxd13 and whale flipper evolution.
- Sonic Hedgehog/Hand2 pathway and whale hind limb loss.
Basically the Hoxd12 and 13 control limb and digit formation in tetrapods. In cetaceans changes to them have caused the forelimbs to return to a 5 digit form and then to web into a flipper.
Adaptive evolution of 5'HoxD genes in the origin and diversification of the cetacean flipper. - PubMed - NCBI
Sonic Hedgehog (Shh) plays a huge role in body development. Limbs, parts of the brain, even teeth are effected by it. In the case of cetacean hind limbs, it's the interaction between Shh and Hand2 that would form their hind legs. Yes, every legged terrestrial tetrapod had hind limbs because of the Shh/Hand2 pathway. In cetaceans that pathway doesn't function so the ebryonic limb buds never develop and are absorbed back into the body. Is this a case of Intelligent design? Who knows? Mosasaurs did just fine for 55 million years with hind flippers. Plesiosaurs and Ichthyosaurs did just fine for nearly 250 million years. Whales have been around for 45 million years.
- Bmp2, fgf8, etc. and bat wing evolution.
Bmp's are bone morphogenetic proteins. Fgf's are Fibroblast growth factors. This paper provides a detailed explanation into how they played a role on the evolution of bat wings.
Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification
- SRGAP2C and ARHGAP11B in human brain evolution
SRGAP2C (the C means it's a variant allele) causes an increase in dendrites in genus Homo.
Human brain shaped by duplicate genes
ARHGAP11B (the B means it's a variant allele) causes the Homo brain to have a larger neocortex and perhaps to have folds increasing brain surface.
Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex | eLife
- LCT/MCM6 regulation and human lactase production into adulthood.
Unless I'm reading it wrong, MCM6 causes LCT to shut down after weaning and to stop producing lactase which allows mammals to digest milk. That means humans with the LCT/MCM6 regulation mutation produce lactase into adulthood and can consume milk and milk byproducts into adulthood.
- CCR5delta32 and HIV immunity
If this one needs explanation, I don't know what to tell you.
- EPAS1 in Tibetans allowing them to function better at altitude.
The EPAS1 variant that Tibetan's carry allows them to function better in a low oxygen environment and to have improved oxygen transport.