Naraoia
Apprentice Biologist
As far as I remember, in that discussion I only ever said that I, personally, don't know if sigma factors have anything to do with morphology. Not sure what the other posters told you but I don't remember anything like your understanding concluded.Yes, in the discussion of sigma factors, my understanding was that we know sigma factors may affect the morphology (of something). But we do not know how.
In the case of Antp, geneticists first had the mutants back in the pre-molecular revolution days of genetics. Since then, they managed to figure out exactly where the gene was and learn a great deal about what it does. (Just to put it in context: Drosophila has 10 000+ genes*)In the fruit fly example, the study is backwards (even it was the best we could do). We changed a gene to see what happened. That is easy. But when we see what changes have happened to a life and trying to figure out which gene mutation caused that, it may be very difficult, or not possible yet.
So no, it's definitely not impossible to find particular genes tied to particular changes. I'm not saying it isn't difficult; in changes influenced by many genes (and often by environmental variables) it is hard to find culprits. But it's far from impossible, especially with the increasingly advanced technology and the growing mountains of genome data we have.
(Why haven't I thought of using the Interactive Fly as a source... it has a massive block of information on Antp, including history:
Interactive Fly gene pages said:[...]Many of the earliest discovered mutations in Drosophila were dominant. This type of mutation is readily produced and easy to spot, since only one copy of the mutated gene is required in order to see a phenotypic effect. As early as 1949 dominant mutations had been found which converted antenna into the second leg [Image] (the mutant adult having no antenna, and two sets of second legs). The name Antennapedia (antenna-foot) was appropriately descriptive. Such homeotic transformations are exciting to contemplate, and serve as the basis of understanding of gene function in Drosophila (Abbott, 1986).
...and apparently lots of stuff on its functions and interactions.)
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*I don't know the latest estimate, but all the more recent ones I've seen are well above 10k.
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