Buddhism does not believe in complete self deniel, but it requires understanding that nothing lasts forever.
We all love good food and good drink and good company and all the toys in the world. But once the food is eaten, the drink drunk, the company enjoyed, and all the toys broken, in order for us to be happy, we need to desire and strive for more of suc things to keep us satisfied.
A truly enlightened person desires nothing but what he/she has. Im of course nowhere near such achievement, but im working towards it.
I believe there is a differance between drive and desire. You should always strive to learn and gain knowledge, but desire in itself causes people to disregard some things, walk over other people in order to get what they desire.
But thats just my personal understanding of course