Personally, I'ld like to point to Nick as evidence for macroevolution. Specifically,
that's the face of YEC creationism right there.
You can tell a lot about the strength of an argument by the quality of it's opponents.
On a more serious note,
Douglas Theobald's 29 Evidences neatly sums up 29 independent lines of evidence for macroevolution.
Personally, I find the strongest evidence to be the fact the nested heirarchies of life.
When the pattern of common decent (the nested heirarchy) can be replicated with good precision (the same nested heirachy each time) by comparing things like the fossil record, proteins, retroviral insertions, transposons and pseudogenes, then you have strong evidence that the pattern of common descent is a valid one.
Each of those methods reveals the same nested heirarchy. Not
a nested heirarchy, but the
same one. By any of those methods, for instance, you will find birds more similiar to alligators than alligators are to turtles, and whales more similiar to bears than whales are to sharks (and the degree will be the same).
Indeed, the pattern is even
predictive. Genetic analysis has caused the shuffling of portions of the tree. There had been debate over the specific origins of hippos. (There were, if I remember, two main possibilities). Genetic analysis indicated one of the two as more likely, and fossils were found matching genetic analysis (timeframe and geographic location included) inside of 2 years.
However, a caveat: Common design can explain
anything, because Common design is unfalsifiable. A designer (especially God) can bloody well do what he wants. Common descent, however, is quite falsifiable and would leave specific patterns. We see those patterns everywhere we look. Personally, I consider that strong evidence of common descent. After all, if only one specific pattern (out of an infinite number) can result from common descent, whereas a Common Designer can make
any pattern, finding the one sole possibility of common descent is far more potent than saying "Well, yeah, but a designer could do that".
Further, if you want to claim "design", you're going to have to explain why your designer replicated mistakes, left in non-functioning code, replicated
viral insertions, and often used sub-optimal solutions when better solutions already existed. A panda's thumb is a crude thing, not nearly as efficient as a human's. Why modify the wrist bone to grow a "thumb", when you've got the thumb already designed for humans?