I think what you are actually speaking about are not changes in the alleles (which would be mutations) but changes in how the alleles are distributed in the population. That, of course, is evolution.
Changes in Allele are not mutations in any form, they are variables in the genetic code that are supposed to be variable.
IE: Blue eyes and Brown Eyes.
There are many variables that make up the human body, and it's systems and function, anything within these variables is not a mutation, it is a product of proper genetic replication.
Could you clarify what you mean by "changes that would go beyond the alleles"?
Sure, improper replication of genetic code, that went beyond the variables within the confines as the variables are allowed.
To give an example, a sheep that was born without hoofs, might be an example of progression beyond allele's. As Hoofs are a constant in the sheep genome, variants in size, shape, color, and even density would be a product of allowed variants in the alleles, them not being there at all, would be a mutation.
I am also puzzled by the phrase "the direction that was proposed by the Macro-Aspect of the Theory of Evolution".
AFAIK the theory of evolution does not propose any preferred direction at all.
It has a direction of decent, IE: The reverse direction, not a foward direction. If you subscribe to the Origin Theory, then life to get to the point it is at this state, followed a specified path to this end result, the objective of Origin Theory is to try and back track the path that was there to start with. From the foundation of this path, as we know it, we can produce forward (effecting the coming generations) paths by which we can shape the "evolution" of life yet to come. However, that second part, is not working so well, and the first part, is not so great either.
Many people do not grasp this, but, evolution has a path, at least, in the sense of back tracking it, Where we came from, and what evolved into what from what. Would be the direction of Evolution as stated.
One standard technique is to establish whether mating is random or assortative. Another would look at the viability of hybrids.
That was a rub in it, one of the key components of Species is Hybrids, and there validity. Even with mating isolation, the validity of the hybrid, is still sound, IE: They can produce viable offspring, they just won't.
Now, in some cases, animals will mate, but not produce viable offspring, like for example, Lions and Tigers will mate, producing a hybrid that is not a viable off spring.
So in one case, they can produce off spring, but won't, in the other case, they can and do mate and produce offspring, but the off spring is not viable.
Which would make them "Sub Species" not separate species.
And the very same pesticides killed them both.
In this case, the idea, is that everything "branches down" Going from the top to the bottom. In that front, there is a direction, which has been built off the Origin Theory aspect of Evolution, however, then there is the claim that there is no direction. Which the two are mutually exclusive claims. But again, I am not here to try and debunk Evolution, or point out it's faults.
However, in the case of say Fruit Flies, they did not have any variation, other then cosmetic and breeding isolation (IE: The same idea as say The Humans in Africa and the Humans in Europe). On the platform of genetics they were still the same thing, but for "what ever reasons" (which is the official technical terms about that issue) won't.
In that front, at that time, one could have said, that when the Europeans met the Africans, they were really meeting a different species of human, and have since then, produced viable off spring, but maintain some pathological and cosmetic difference.
So, this makes it an issue, where and why you draw that line as "species", what is, and what is not.
And unless the line is drawn at a viable point, of Can Not, and the Genetic Change has been done to this point, the classification of Species, is just arbitrary, and may or may not be viable support for the demand of species division. It needs to progress beyond the arbitrary line.
God Bless
Key.