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Depression can often have a physiological aspect, which means that an examination by a physician will frequently be a good starting point in addressing the situation and any underlying problems. Severe, ongoing depression isn’t something we should become resigned to or attempt to cope with alone; professional assistance should generally be obtained, usually after a doctor has ruled out a physical or chemical cause.
But almost everyone suffers from a mild form of depression from time to time, and in such situations, the experiences of some of the saints may be able to help and encourage us.
I find the lives of the saints very inspiring. It is comforting to know that they too experienced times of depression, melancholy and desolation.Another powerful personality — one also given to feelings of deep restlessness and grief — was possessed by St. Ignatius of Loyola. In his autobiography (written in the third person), Ignatius stated, “The things he saw strengthened him then and always gave him such strength in his faith that he often thought to himself: if there were no Scriptures to teach us of these matters of the Faith, he would be resolved to die for them, only because of what he had seen.” This sense of certainty and conviction had not come easily; after his conversion to the Faith, Ignatius had to struggle with a period of scrupulosity (in which he was tempted to despair of ever being worthy in God’s sight), followed by a depression so severe that he actually considered suicide. Of course, he persevered, and God drew him out of the dark pit of inner suffering, through which he had been prepared to do great things on behalf of Christ and His Church.
St. Ignatius experienced first-hand what he was later to refer to as desolation in his Spiritual Exercises. Much akin to depression, desolation is a state in which we feel restless, irritated, uncomfortable, unsure of ourselves and our decisions, assailed by doubts, and unable to persevere in our good intentions. According to Ignatius, God cannot cause desolation, although He may allow it for His own purposes — such as to remind us of our profound need for Him, or to “shake up” a sinner so as to bring about repentance. Feelings of desolation, Ignatius notes, are often caused or provoked by the evil one, especially after we’ve taken practical steps to grow in holiness or to discern and follow God’s will.
https://catholicexchange.com/saints-and-depression