I consider myself to be an "expert" on meds for bipolar. I have been treated for this disease for approximately ten years. I have taken depakote (zombie land), lithium (hospitalized for poisoning), wellbutrin (no response whatsoever), paxil (okay, but led to mania), zoloft (like taking placebo), zyprexa (great but weight gain), symbyax (even better, but weight gain), prozac (no no for bipolar without mood stabilizer), effexor (no effect at all), carbamazapine (lost time), trazodone (too sleepy), lamictal (again nothing), abilify (WAY to freaking expensive) and am now taking seroquel.
I get extremely tired with the seroquel, but the trade off is worth it. This is the best medication I have been on (in my opinion). I am suprised at the comments about weight gain. I have lost 15 pounds on this medication. (I did well on the symbyax too, but gained weight... and I am really sensitive about this issue which fuels my depression). The zoloft is like water to me, no benefit, no drawback. Maybe it will work for you.