I have to be able to get the 60th percentile on the ACS exams. So, resonance, a lot of mechanisms, spectra without a chart to a degree, hybridization, stability or resonance forms, sigma/pi bonds (which is apparently also used to determine if something is aromatic...?), functional groups, etc, etc, etc. But I don't need to make the lab grades again, I have enough lab classes to show that I know my way around in lab.
Metherion
The ACS exam will likely be way easier than your regular exams. Take heart in that! Most of my friends spent minimal effort studying for the final after doing well in the class got at least 60th percentile on the ACS exam. Be sure to get the official practice book, that thing is a life-saver.
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