Most of what she said about history is well accepted, but the overall impression is misleading.
In the OT, it’s pretty clear that up to about Joshua there’s not a lot of historical content, though I suspect Moses actually did exist. That’s the period she talks about in the beginning as not happening. However starting with David, and probably Judges, it’s more plausible. The destruction of Jerusalem and the exile did happen, and she implicitly acknowledges it. While she doesn’t say anything specific that’s false, she gives the false impression that none of the Bible is historically true.
It also doesn’t discuss the historicity of the NT, though listeners probably assume it’s included in the judgement that the Bible isn’t historically true. I think what she does say is misleading. God is not absent from the NT. Jesus’ teachings are mostly about what he’s like and what he wants from us. While Paul talks a lot about Christ, his emphasis is on God's plan involving Christ, so God is at the center there as well. That's true whether you agree with her judgement about Paul or not. It's obvious that she is an OT scholar, since the terms in which she discusses Paul seem divorced from current Pauline scholarship (though it also doesn't seem that she was all that interested in informing people about current Biblical scholarship -- despite her claim to respect religious people it seemed more like making fun of the Bible than informing people about scholarship).
The thing at the end wasn’t intended as serious, I guess, but just because the people who made the toy he showed can’t tell male and female lions apart doesn’t mean that God or the Bible couldn’t.