sfs
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- Jun 30, 2003
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For determining a tree, what matters is really the pattern of similarities and differences. In particular, DNA that is the same among a group of species but different from the DNA of other species is a signal that those species form a branch of the tree. If you keep seeing the same species grouped together with different shared unique genetic markers, that's excellent evidence that they form a branch.Ive wondered about this for some time. The idea that it isnt similarities in DNA that make up the tree of relatedness, rather it is the differences that make the tree as it is. Could you talk a bit about this?
This plays out with lots of different genetic markers. All higher primates, for example, share large deletions from GULO, a gene needed to make vitamin C. Closely related primates share specific single-base mutations in the gene that aren't seen in other primates. Insertions of a particular endogenous retroviruses are unique events, unlikely ever to recur at the same place in the genome. As a result, they mark the branch of the tree on which they occurred; similarity within the branch indicates relatedness, but only by contrast with all of the other species that lack the insertion.
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