One can have inherited the gene for being an alcoholic, if you have not had a drink of alcohol, you won't even know it, and you will never have a problem. If you do take that first drink and you remain in that drunken state, you're lost, in this world and the next. If you get sober and remain sober, you'll have overcome. Even though you may have the strong desire to go back to it, remaining sober will become a lifetime struggle to remain that way. You can insert any other tendency instead of alcohol into that.
It no sin to be tempted, for Christ was tempted. It's giving in to it that becomes a problem.
Have no idea what Enoch may have inherited. All I know is that he walked with God and was so close to Him, that he did not have to have that first death, and neither did Elijah. Whatever tendencies they may have had, they did not give in to those tendencies.
The American Indian is about the only culture I know of that did not have some form of alcohol until the whites arrived and gave it to them. Until then, they had no idea that they had a genetic predisposition to alcoholism. They didn't have teepees dedicated to the sole purpose of hanging out and drinking. They did use mind altering substances, but those were limited to ceremonial times. They had tabbacco, but that also was used for ceremonial purposes. As far as I know, they did not use it like the whites as a daily thing. Have not heard of Indian chain smokers with their pipes.