Hi, I am a psychiatric patient diagnosed with schizoaffective disorder, I have just recently found something that helps me alot, it is the pain-killer aspirin! Apparently it is a COX-2 inhibitor and is currently being investigated as an experimental treatment for schizophrenia. There have been numerous times when I was in severe mental distress and I took 2 Alka-Seltzer tablets in a glass of water and I made a miraculous recovery within about an hour and 1/2 and was fine for the rest of the day! It definently has an effect! Apparently aspirin can cause stomach irritation and bleeding but Alka-Seltzer is much less likely to cause this than pills, I have been taking 1 Alka-Seltzer per day for about a week and I am fine.