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Evolution's Demonstrated Mechanism

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mark kennedy

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I have a very general question with a very specific focus for the forum if anyone is interested. I want to talk about evolution's demonstrated mechanism, specifically with regards to the cleavage stage. Here is what I would like you to consider:

"Without a naturalistic mechanism to account for homology, however, Darwinian evolution cannot claim to have demonstrated scientifically that living things are undesigned, and the possibility remains that homologies are patterned after non-material archetypes. Without a demonstrated mechanism, naturalistic biologists are left with only one alternative: exclude design a priori, on philosophical grounds."

Homology: A Concept in Crisis

Natural Selection is not a mechanism that produces life, it produces extinction for the less fit. This is the specific point I would like to see addressed and dispite my best efforts I have yet to see an evolutionist deal with it:

"The diversity of the earliest stages of development, here illustrated strictly within the vertebrates, provides one of the strongest challenges to the neo-Darwinian conception of homology and macroevolution. Given the hierarchical, step-wise logic or "architecture" of animal development, early stages such as cleavage and gastrulation lay the groundwork for all that follows. Body plan structures in the adult, for example, trace their cellular lineage to these early stages. Thus, if macroevolution is going to occur, it must begin in early development. Yet it is precisely here, in early development, that organisms are least tolerant of mutations. Furthermore, the adult homologies shared by these vertebrates commence at remarkably different points (e.g., cleavage patterns). How then did these different starting points evolve from a common ancestor?"

The Clevage Stage

Feel free to respond in anyway you see fit, I only ask that the discussion focus on the demonstrated mechanism for Evolution.
 
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lucaspa

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mark kennedy said:
"Without a naturalistic mechanism to account for homology, however, Darwinian evolution cannot claim to have demonstrated scientifically that living things are undesigned, and the possibility remains that homologies are patterned after non-material archetypes. Without a demonstrated mechanism, naturalistic biologists are left with only one alternative: exclude design a priori, on philosophical grounds."
A strawman from the beginning. Natural selection is an algorithm to get design. So, biological organisms are designed, but designed by natural selection. The proof that natural selection is a designer is that humans use natural selection to design when the design problem is too tough for them.

Natural Selection is not a mechanism that produces life, it produces extinction for the less fit.
Natural selection preserves good designs. This was emphasized by Darwin when he described natural selection, but apparently creationists either do not read Darwin or choose to break the 9th Commandment when discussing evolution. Below is how Darwin summarized natural selection, notice the bold.

"If, during the long course of ages and under varying conditions of life, organic beings vary at all in the several parts of their organization, and I think this cannot be disputed; if there be, owing to the high geometric powers of increase of each species, at some age, season, or year, a severe struggle for life, and this certainly cannot be disputed; then, considering the infinite complexity of the relations of all organic beings to each other and to their conditions of existence, causing an infinite diversity in structure, constitution, and habits, to be advantageous to them, I think it would be a most extraordinary fact if no variation ever had occurred useful to each beings welfare, in the same way as so many variations have occured useful to man. But if variations useful to any organic being do occur, assuredly individuals thus characterized will have the best chance of being preserved in the struggle for life; and from the strong principle of inheritance they will will tend to produce offspring similarly characterized. This principle of preservation, I have called, for the sake of brevity, Natural Selection." [Origin, p 127 6th ed.]

This is the specific point I would like to see addressed and dispite my best efforts I have yet to see an evolutionist deal with it:
You haven't been looking for information hard enough. There are a number of good sources of developmental biology on the web. One of them is at http://zygote.swarthmore.edu/index.html

Now, if you go to the next page and look at "Early Development", you come to this page: http://faculty.washington.edu/bjswalla/ among others, and this research deals specifically with the issue you pose.

You can also go to this page http://zygote.swarthmore.edu/chap5.html and find a chapter in a Developmental Biology book online dealing specifically with cleavage. The central page for chapters on the book is http://zygote.swarthmore.edu/info.html

And this page will deal with the issue of homologies from the perspective of developmental biology http://zygote.swarthmore.edu/evo7.html The key here is "functional cassettes" of developmental genes.

"The diversity of the earliest stages of development, here illustrated strictly within the vertebrates, provides one of the strongest challenges to the neo-Darwinian conception of homology and macroevolution. Given the hierarchical, step-wise logic or "architecture" of animal development, early stages such as cleavage and gastrulation lay the groundwork for all that follows. Body plan structures in the adult, for example, trace their cellular lineage to these early stages. Thus, if macroevolution is going to occur, it must begin in early development. Yet it is precisely here, in early development, that organisms are least tolerant of mutations. Furthermore, the adult homologies shared by these vertebrates commence at remarkably different points (e.g., cleavage patterns). How then did these different starting points evolve from a common ancestor?"

The Clevage Stage

Feel free to respond in anyway you see fit, I only ask that the discussion focus on the demonstrated mechanism for Evolution.[/QUOTE]
 
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mark kennedy

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lucaspa said:
A strawman from the beginning. Natural selection is an algorithm to get design. So, biological organisms are designed, but designed by natural selection. The proof that natural selection is a designer is that humans use natural selection to design when the design problem is too tough for them.

Baloney! Natural Selection simply makes extinct the species or subspecies that is less fit. It is based on Maltusian geometric growth of populations and it is a mechanism for extinction by definition.

Natural selection preserves good designs. This was emphasized by Darwin when he described natural selection, but apparently creationists either do not read Darwin or choose to break the 9th Commandment when discussing evolution. Below is how Darwin summarized natural selection, notice the bold.

Apparently Darwinians don't bother to read Darwin but lets look at the quote you cut and pasted.

"If, during the long course of ages and under varying conditions of life, organic beings vary at all in the several parts of their organization, and I think this cannot be disputed; if there be, owing to the high geometric powers of increase of each species, at some age, season, or year, a severe struggle for life, and this certainly cannot be disputed; then, considering the infinite complexity of the relations of all organic beings to each other and to their conditions of existence, causing an infinite diversity in structure, constitution, and habits, to be advantageous to them, I think it would be a most extraordinary fact if no variation ever had occurred useful to each beings welfare, in the same way as so many variations have occured useful to man. But if variations useful to any organic being do occur, assuredly individuals thus characterized will have the best chance of being preserved in the struggle for life; and from the strong principle of inheritance they will will tend to produce offspring similarly characterized. This principle of preservation, I have called, for the sake of brevity, Natural Selection." [Origin, p 127 6th ed.]

How? How are these characterizations produced? That is the question and you have no demonstratable mechanism for that. This is the scientific mechanism for equilibrium but none for evolution. Nice try quoting Darwin but I have read the book and it offers more questions then answers.

You haven't been looking for information hard enough. There are a number of good sources of developmental biology on the web. One of them is at http://zygote.swarthmore.edu/index.html

Now, if you go to the next page and look at "Early Development", you come to this page:

I read your divisionary tactic and it doesnt provide a mechanism for this mythical monstrocity or address the issue of evolution during the cleavage stage. I knew you were unable to address this issue but I decided to remove you from the ignore list to see if you addressed the issue at hand. Here is the issue at hand, think about it before you respond:

"Given the hierarchical, step-wise logic or "architecture" of animal development, early stages such as cleavage and gastrulation lay the groundwork for all that follows... How then did these different starting points evolve from a common ancestor? "

You are in uncharted waters here, don't bother with the liniks, they can't help you here. I suggest you try actually reading the source material before you ramble on about things you never bothered to think about.
 
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lucaspa

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mark kennedy said:
Baloney! Natural Selection simply makes extinct the species or subspecies that is less fit. It is based on Maltusian geometric growth of populations and it is a mechanism for extinction by definition.
Natural selection works on individuals, not on species or subspecies. What natural selection does is pick the individuals with the best design for the situation. As you noted. Matthusian geometric growth itself guarantees that a lot of individuals are going to die. There are simply too many individuals for the limited resources to support. So the death of individuals has nothing to do with natural selection -- instead natural selection picks the individuals with the best designs and then, by inheritance, insures that those designs are passed to the next generation.


How? How are these characterizations produced? That is the question and you have no demonstratable mechanism for that.
Hmm, you changed the claim. Your first claim was that natural selection was "extinction". I used Darwin to point out to you that NS is preservation. Well, you are not arguing that, but have switched claims. So I guess we can conclude that NS is preservation and not extinction. Your first claim is abandoned.

Now, as to your new claim -- "how are these characterizations produced" -- the answer is in the first sentence: If, during the long course of ages and under varying conditions of life, organic beings vary at all in the several parts of their organization, and I think this cannot be disputed; Those variations return as "But if variations useful to any organic being do occur, assuredly individuals thus characterized "

You know full well how the variations/characterizations are produced.
1. Sexual recombination.
2. Mutation.

Natural selection has two components. Both have to be present.
1. Variation.
2. Selection. As you noted, Malthusian geometric proliferation ensures that more offsrping are produced than can survive to reproduce. Thus, there must be selection among all the members of the population for those that will survive and reproduce. The selection is done in the metaphorical Struggle for Existence, which Darwin and others have documented. The competition for those scarce resources. Individuals with the better designs will get the resources in the competition. Thus they will survive and reproduce, passing the good designs to the next generation.

I read your divisionary tactic and it doesnt provide a mechanism for this mythical monstrocity or address the issue of evolution during the cleavage stage.
:sigh: I knew you wern't honest enough to read the material, but I hoped anyway.

What you are doing is looking at the physical results of cleavage and saying "there must be homology in the structure of cleaved blastocyst. Since there is no homology of structure, there is no homology". What developmental biologists are looking at are the genes that control the process and saying there is homology in the genes!

"HOMOLOGIES OF PROCESS



It is well established that certain structures are homologous. These include things like the arm of a human and the flipper of a seal and the eing of a bird. They are constructed from the same basic elements arranged in a similar manner. It is also well established that molecules can be homologous. Thus, the globin proteins or genes of humans are homologous to those of a horse or a bat. Homology indicates a similarity established through common descent. ...
"There is now evidence that certain developmental pathways are themselves homologous both within an organism and between phyla. This goes beyond the several developmental regulatory genes (Pax6, finge, tinman, the Hox genes) that have been found to be extremely well conserved throughout animal evolution (see Gilbert, 1997). ...
However, whereas the structure and expression pattern of one set of genes may not be an indication of homology, the coordinated assembly of several genes and gene products into functional cassettes does indicate homologous relationships if these casettes are shared between species or between tissues within an organism. Here we see that pathways can be homologous, and we get into a new understanding of homology: the homology of process."
http://zygote.swarthmore.edu/evo7.html

Thus, the homology of cleavage is not homology of the structure of the cleaved blastocyst, but homology of the functional cassette of genes that controls the process of cleavage.

I knew you were unable to address this issue but I decided to remove you from the ignore list to see if you addressed the issue at hand. Here is the issue at hand, think about it before you respond:

"Given the hierarchical, step-wise logic or "architecture" of animal development, early stages such as cleavage and gastrulation lay the groundwork for all that follows... How then did these different starting points evolve from a common ancestor? "

You are in uncharted waters here, don't bother with the liniks, they can't help you here.
No, the waters aren't uncharted. Just unread by you! I suggest you take your own advice and "actually reading the source material before you ramble on". Go to the source material and see if you can use that to refute the above. Good luck.

"
1. The Hedgehog-Wnt pathway

The concept of process homology can be traced to the observations of Howard Schneiderman. He observed homologous specification--the phenomena wherein transdifferentiating cells or the products of homeotic gene mutations have a pre-existing positional information relevant to where they reside in the imaginal disc. A piece of antenna tissue that differentiates as a leg will differentiate according to its location in the antennal disc. Schneiderman's observations (see Postlethwait and Schneiderman, 1971) were particularly important because they helped show that homology had to be defined at a particular level. Structures with no anatomical homology--the eye and the leg--may have an underlying homology of process. Hense his term, homologous specification. We are now becoming aware of the process homology that unites the eye, the wing, and the leg discs. It is the hedgehog/Wnt pathway. These two paracrine factors interact within the disc to specify the proximal/distal, dorsal/ventral, and anterior/posterior axes. The same molecules that specify these axes in the eye also specify them in the leg and wing discs. So we have a serial process homology. Moreover, the same pathway exists in vertebrates. Every member of the pathway in insects has a homologue in the vertebrate embryo, and the same interactions that transmit the Drosophila Wingless signal to the nucleus through armadillo and pangolin protein are seen in the vertebrates, wherein the Wnt signal is manifest in the entry of beta-catenin and Lef-1 into the nucleus. The genes are the same and the protein interactions are the same. Only the readout is changed from tissue to tissue and from species to species. Interestingly, the same Wnt/hedgehog interactions seen in producing the fly limbs are seen in the interactions that are involved in the morphogenesis of vertebrate limbs. If a vertebrate hedgehog protein (which is usually synthesized only in the posterior mesoderm) is expressed anteriorly, the limb develops a mirror-image duplication. This is the same phenomenon that occurs when hedgehog protein is induced to form in the anterior portion of the fly wing disc (see Ingham, 1994). " http://zygote.swarthmore.edu/evo7.html

"
Most discussions of homology have not discussed processes as being homologous. This is to be expected, since evolutionary biology and systematics has been predominantly a study of adult structures. But if homologies are to be observed in the embryo, they shouldbe homologies of processes, not structures. It was C. H. Waddington who emphasized the importance of processes. As Waddington (1975) wrote:

As far as scientific practice is concerned, the lessons to be learned from Whitehead were not so much derived from his discussions of experiences, but rather from his replacement of "things" by processes which have an individual character which depends upon the "concrescence" into a unity of very many relations with other processes."

In terms of embryos, Waddington envisioned the concrescences of numerous genes and their products into a stabilized pathways. These developmental pathways were real "things", and they were subject to natural selection. Whitehead was much respected by the embryologists of the 1930s because he viewed the concept of "becoming" as superior to that of "being." As Whitehead (1933) viewed reality, "the very essence of actual reality--that is, of the completely real--is process. Thus each actual thing is only to be understood in terms of its becoming and perishing...The process is itself the actuality..." Today, we are extending Waddington's Whiteheadian notion that developmental pathways are themselves real and selectable things by noting that like "things"--limbs, ribs, wings, nucleotide sequences, amino acid sequences--they can be homologous both within and between organisms. "
 
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mark kennedy

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Thus, the homology of cleavage is not homology of the structure of the cleaved blastocyst, but homology of the functional cassette of genes that controls the process of cleavage.

Fine, just identify the 'functional cassette of genes' and then you have a demonstrated mechanism. Of course, this must be reduced to a universal principle that can be reduced to mathmatical functions. I read the article you seem to think has so much relevance and philosophically its tied to Whitehead, which is interesting since his philosophy is opposed to materialism.

Oh and you might want to demonstrate how the structure of cleaved blastocyst is different then the functional cassette of genes.

Both of these statements cannot be true:

So the death of individuals has nothing to do with natural selection

There are simply too many individuals for the limited resources to support.

One is an expression of the Malthsian principle of geometric growth and the extinction of lessor races and the other is a flat denial of his most important premise. Darwin defined this as Natural Selection which is nothing more then an elaborate mythology.

In terms of embryos, Waddington envisioned the concrescences of numerous genes and their products into a stabilized pathways. These developmental pathways were real "things", and they were subject to natural selection. Whitehead was much respected by the embryologists of the 1930s because he viewed the concept of "becoming" as superior to that of "being." As Whitehead (1933) viewed reality, "the very essence of actual reality--that is, of the completely real--is process. Thus each actual thing is only to be understood in terms of its becoming and perishing...The process is itself the actuality..." Today, we are extending Waddington's Whiteheadian notion that developmental pathways are themselves real and selectable things by noting that like "things"--limbs, ribs, wings, nucleotide sequences, amino acid sequences--they can be homologous both within and between organisms. "

Waddington envisioned genes being produced into stabilized pathways but never demonstrated the mechanism. 'Becoming is the very essense of actual reality'...'the process itself the actuality'...'developmental pathways are themselves real and selectable'. Ok, since we are discussing how homology is demonstrated in the early stages of development show me the homology in these embryos.

Now lets compare this to Darwin:

"the embryos of mammals, birds, fishes, and reptiles" are "closely similar, but become, when fully developed, widely dissimilar...are the modified descendants of some ancient progenitor." According to Darwin, "the embryonic or larval stages show us, more or less completely, the condition of the progenitor of the whole group in its adult state"

Now try the diagram on the cleave stages and show me the homology.

http://www.arn.org/docs/odesign/od182/hbfig4.htm

You have only to open any Biology textbook and you will find the Karl Ernst von Baer comparisons of embryos that is meant to demonstrate how we evolved from a single common ancestor that had gills.

http://www.windowview.org/science/24embryo.html
 
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rmwilliamsll

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Natural Selection is not a mechanism that produces life, it produces extinction for the less fit

it produces a differential survival rate. the poorly fit rate is not necessarily zero as you propose.

i had only one senior/1st year grad class in developmental bio. the prof made it clear that all of us in the room were the winners of the hardest contest we would ever participate in---gastulation.

if common descent is not a fact then all the work on fruit flies and nemetodes would not be so transferable to higher organisms as they are. same genes control development but in slightly different ways. again the nested hierarchical nature of common descent raises its very important head.


btw, the zygote.swarthmore site is excellent and was along with:
http://flybase.bio.indiana.edu/

key elements of the class i had.
 
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