So, us evolution-minded folk are sometimes told that diseases, injuries, etc. are all consequences of the big, bad Fall. Let's have a look at one that I recently learned more about.
Down's Syndrome, or Trisomy-21, occurs when one of the parent gametes carries an extra copy of chromosome 21. Further examination shows us that most instances of non-disjunction occur during maternal meiosis I. That is an interesting, yet unsurprising discovery. During maternal meiosis (gamete formation), the ovum undergoes a partial prophase I - the chromosomes replicate and connect to form dyads, which then connect again (syapse), at a point called the chiasmata, to form tetrads. This happens to every potential ovum (oocyte) a female possesses. The oocytes then remain in this state until released during ovulation. Many cases of Trisomy-21 are associated with non-disjunction at the chiasmata during the completion of meiosis at ovulation.
Now, it is commonly known that the chance of having a Down's child increases as a function of maternal age. The precise cause of non-disjunction is unknown, but it is plausibly related to the fact that oocytes remain in mid-prophase I until the female undergoes ovulation or menopause. Thus, a 35-year-old female is ovulating with oocytes that have been in synapsis for 35 years.
So, if we try to square this with Genesis, we are apparently to believe that the Fall caused Eve's oocytes to progress forward in meiosis just enough to synapse - for apparently no good reason except to facilitate the development of trisomic offspring.
Yikes.
Down's Syndrome, or Trisomy-21, occurs when one of the parent gametes carries an extra copy of chromosome 21. Further examination shows us that most instances of non-disjunction occur during maternal meiosis I. That is an interesting, yet unsurprising discovery. During maternal meiosis (gamete formation), the ovum undergoes a partial prophase I - the chromosomes replicate and connect to form dyads, which then connect again (syapse), at a point called the chiasmata, to form tetrads. This happens to every potential ovum (oocyte) a female possesses. The oocytes then remain in this state until released during ovulation. Many cases of Trisomy-21 are associated with non-disjunction at the chiasmata during the completion of meiosis at ovulation.
Now, it is commonly known that the chance of having a Down's child increases as a function of maternal age. The precise cause of non-disjunction is unknown, but it is plausibly related to the fact that oocytes remain in mid-prophase I until the female undergoes ovulation or menopause. Thus, a 35-year-old female is ovulating with oocytes that have been in synapsis for 35 years.
So, if we try to square this with Genesis, we are apparently to believe that the Fall caused Eve's oocytes to progress forward in meiosis just enough to synapse - for apparently no good reason except to facilitate the development of trisomic offspring.
Yikes.