Combating the leading Cause of Human Mortality

[Coolerranch]

AGC Biologics and Repair Biotechnologies Partner on Novel mRNA Therapeutic to Combat the Leading Cause of Human Mortality

AGC Biologics is manufacturing an mRNA therapy for Repair Biotechnologies to tackle one of the world's most persistent health challenges and cause of mortality.

www.agcbio.com

 

[DaisyDay]

For those wondering, the - well, one of the - leading causes of human mortality is atherosclerotic cardiovascular disease, according to the linked article.

Cool if it works.

 

[ThatRobGuy]

I hate to be "that guy"

But we've already known about very effective treatment and prevention for atherosclerotic cardiovascular disease, people just don't like it lol.

It's called eating healthier and exercise.



Obviously you're going to have some extreme cases that are "too far gone", so certain therapeutics could be beneficial to that cohort, but it would be a shame if these sort of "therapeutics of last resort" followed the same pattern as Ozempic. Where everyone just started taking them to avoid having to exert any willpower.

 

[Nithavela]

I hate to be "that guy"
But we've already known about very effective treatment and prevention for atherosclerotic cardiovascular disease, people just don't like it lol.

It's called eating healthier and exercise.



Obviously you're going to have some extreme cases that are "too far gone", so certain therapeutics could be beneficial to that cohort, but it would be a shame if these sort of "therapeutics of last resort" followed the same pattern as Ozempic. Where everyone just started taking them to avoid having to exert any willpower.

There is no reason why the root causes for atheriovascular disease shouldn't be attacked on more than one front, unless the idea is to punish those who don't pass some arbitrary morality test. While most people know how to eat and exercise to keep the chance of developing these issues low, modern life makes it quite hard. Why not promote both healthy living and use modern science to keep people out of the grave for a little longer?

 

[Larniavc]

Why not promote both healthy living and use modern science to keep people out of the grave for a little longer?

Because the idea is to punish those who don't pass some arbitrary morality test.

 

[Nithavela]

Because the idea is to punish those who don't pass some arbitrary morality test.

I think the goal is to feel morally superior without actually doing anything, but that is part of the method, yes.

 

[Larniavc]

I think the goal is to feel morally superior without actually doing anything, but that is part of the method, yes.

Not doing anything is a big part of America: gun crime? Nothing can be done. Health care? Nothing can be done. Climate change? Nothing can be done. Oligarchs owning politicians? Nothing can be done. Wealth inequality? Nothing can be done.

It’s probably learnt helplessness.

 

[Nithavela]

Not doing anything is a big part of America: gun crime? Nothing can be done. Health care? Nothing can be done. Climate change? Nothing can be done. Oligarchs owning politicians? Nothing can be done. Wealth inequality? Nothing can be done.

It’s probably learnt helplessness.

Probably also a healthy dose of cognitive dissonance. If tomorrow the USA would solve any of those issues by implementing the measures experts agree on, all the suffering up to that point would have been preventable and senseless. Better to pretend that no solution is possible so you don't feel bad.

 

[ThatRobGuy]

There is no reason why the root causes for atheriovascular disease shouldn't be attacked on more than one front, unless the idea is to punish those who don't pass some arbitrary morality test. While most people know how to eat and exercise to keep the chance of developing these issues low, modern life makes it quite hard. Why not promote both healthy living and use modern science to keep people out of the grave for a little longer?

It's fine to attack a problem on more than one front, but people have been increasingly going with whatever is "quick & easy" without any consideration for potential issues. (Like with Ozempic)

There are younger people, who are in no immediate risk of a major health event, taking that approach.

 

[Nithavela]

It's fine to attack a problem on more than one front, but people have been increasingly going with whatever is "quick & easy" without any consideration for potential issues. (Like with Ozempic)

There are younger people, who are in no immediate risk of a major health event, taking that approach.

Well, good luck with tackling that issue. While the current health secretary paid a lot of lip service towards promoting healthy eating habits and eliminating unhealthy food, I don't think he actually implemented a lot of concrete measures.

 

[ThatRobGuy]

Well, good luck with tackling that issue. While the current health secretary paid a lot of lip service towards promoting healthy eating habits and eliminating unhealthy food, I don't think he actually implemented a lot of concrete measures.

I don't know that we needed the government to tell people
McDonalds, candy, and coca cola aren't good to have 3 to 4 nights a week, and you should probably get out and move a little more

To her credit, Michelle tried as well with the get out and move and the healthy school lunch initiative, as well as expansions to the food assistance programs that allowed for purchases at stores that offer healthier options that happened under her husband's admin.

...the schools ended up throwing away a lot of that healthy food because the kids wanted chicken nuggets, pizza, and fries.

Food assistance programs still ended up getting mostly used on junk food.

Soda is still the #1 most purchased food category with SNAP, and sugar sweetened beverages and candy still account for 28% of all SNAP dollars spent. America seems to have a very unhealthy relationship with food.

And the obesity rates really start their massive upward shift in the 1980's.
1980: A significant acceleration began, with adult obesity rising from 13.4% 1980 to over 34% by 2008, and childhood obesity from 5% to 17% in the same period.

And while I obviously wouldn't condone people being bullied for their weight, I do think we swung the pendulum too far in the other direction. Where even publishing healthy BMI ranges and doctors telling patients they need to lose weight started getting labelled as "fat shaming".

 

[Laodicean60]

And the obesity rates really start their massive upward shift in the 1980's.

Thanks to big sugar, non-alcoholic fatty liver also became a thing at that time. Doctors created a new disease because they didn't know why non-alcoholics were getting fatty liver.

 

[ThatRobGuy]

I'd also read an interesting thing by a doctor who worked with diabetics from the Cleveland Clinic about that as well

The 80's was also the explosion of the diet the sodas as well. Which, on the surface, seems counterintuitive as a culprit given that they have no calories. However, they talked about how heavy use of diet sodas still stimulated the same part of the brain, and adjusted the palette/preferences toward sweet stuff

Tricking Taste Buds but Not the Brain: Artificial Sweeteners Change Brain’s Pleasure Response to Sweet

Do NOT EAT the chemicals. It is the #1 laboratory safety rule young scientists learn to never break and for good reason; it keeps lab citizens alive and unscathed.

www.scientificamerican.com

 

[Desk trauma]

I think the goal is to feel morally superior without actually doing anything, but that is part of the method, yes.

The opposition to the various weight loss shots and now this possible therapy for blocked arteries is the secular take on the opposition to HPV vaccines. It does not matter if the health outcomes are improved, it's more important that people improve their health the correct way and suffer if they do not.

Never mind that cervical cancer could be eradicated, don’t take the shot keep your legs closed.

Doesn’t matter that our obesity rate is declining for the first time in a decade, using the shot is cheating eat less move more.

Cardiovascular disease could be possibly reversed with a therapy? Nah, change your diet and work out.

The outcome is secondary to how it’s achieved, at best.