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Everlasting33
Guest
As someone who has tried up to 10 different anti-depressants, I have had my doubts on these medications.
I look through many depression forums and I have noticed a wide range of "failure" on the part of anti-depressants.
I was reading a book called "Psychology Debunked" where this idea was introduced to me. At first, I was adamant that the author was wrong. But, after doing some research on my own and realizing that not one anti-depressant helped, I am more convinced that anti depressants do not work.
I have found several sites on this topic but because of forum rules, I am unable to post them here. Here is an excerpt from one:
"Antidepressants are believed to exert their therapeutic effects by acting on brain monoamines, which are believed to be important determinants of mood. However, in a circular chain of logic, the monoamine theory of depression was itself formulated primarily in response to observations that early antidepressants increased brain monoamine levels [ 3].
Independent evidence has not confirmed that there is a monoamine abnormality in depression. For example, the findings of brain imaging studies of serotonin abnormality are contradictory. Some found reduced serotonin 1A receptor binding in drug-free patients who were depressed, consistent with the hypothesis that selective serotonin reuptake inhibitors (SSRIs) improve depression by correcting a deficiency of serotonin activity [ 4, 5]. Other studies, however, have found no difference between patients who are drug-free and controls [ 6, 7] or increased binding potential in depressed patients [ 7, 8]. Postmortem findings of receptor changes in the brains of people who committed suicide have also been inconsistent [ 911]. In some studies, with patients who had recovered from depression, a tryptophan depletion challenge led to a transient increase in depressive symptoms. However, these results have not been confirmed in volunteer studies [ 12], and the effect appears to be dependent on previous SSRI use [ 13]. Research on catecholamines (noradrenaline and adrenalin) is similarly confusing and inconclusive [ 14]. "
If anyone wants more information, please PM me.
And if anyone has had great success, please do share!
NOTE: I am not advocating someone stopping medication. I simply want to spread some of the information that I have received and perhaps it can helpful to others. I hope this thread is allowed.
I look through many depression forums and I have noticed a wide range of "failure" on the part of anti-depressants.
I was reading a book called "Psychology Debunked" where this idea was introduced to me. At first, I was adamant that the author was wrong. But, after doing some research on my own and realizing that not one anti-depressant helped, I am more convinced that anti depressants do not work.
I have found several sites on this topic but because of forum rules, I am unable to post them here. Here is an excerpt from one:
"Antidepressants are believed to exert their therapeutic effects by acting on brain monoamines, which are believed to be important determinants of mood. However, in a circular chain of logic, the monoamine theory of depression was itself formulated primarily in response to observations that early antidepressants increased brain monoamine levels [ 3].
Independent evidence has not confirmed that there is a monoamine abnormality in depression. For example, the findings of brain imaging studies of serotonin abnormality are contradictory. Some found reduced serotonin 1A receptor binding in drug-free patients who were depressed, consistent with the hypothesis that selective serotonin reuptake inhibitors (SSRIs) improve depression by correcting a deficiency of serotonin activity [ 4, 5]. Other studies, however, have found no difference between patients who are drug-free and controls [ 6, 7] or increased binding potential in depressed patients [ 7, 8]. Postmortem findings of receptor changes in the brains of people who committed suicide have also been inconsistent [ 911]. In some studies, with patients who had recovered from depression, a tryptophan depletion challenge led to a transient increase in depressive symptoms. However, these results have not been confirmed in volunteer studies [ 12], and the effect appears to be dependent on previous SSRI use [ 13]. Research on catecholamines (noradrenaline and adrenalin) is similarly confusing and inconclusive [ 14]. "
If anyone wants more information, please PM me.
And if anyone has had great success, please do share!
NOTE: I am not advocating someone stopping medication. I simply want to spread some of the information that I have received and perhaps it can helpful to others. I hope this thread is allowed.
I understand the doubts. Ive been dead against anti-depressants ever since I had a bad side effect to one. I was set against them. But ive been struggling so much I guess I gave in at the end. Im on prozac. I did have bad lack of sleep through them and loss of apetite
