We know he's not sleeping during those hours that he's making posts (unless someone else is making them, which is a different category of problem).
If Trump is not sleeping because of some commonly occurring age-related physical problem like an enlarged prostate that decreases the capacity of the bladder and hinders complete bladder emptying, then that implies a mental or psychological problem...and is again a different category of problem.
A number of years ago, I was barely sleeping an hour in the night without being forced to get up. My physician checked my prostate and exclaimed, "Wow!" He sent me to a urologist who said, "If that was a buck, you'd mount it." My prostate is twice the volume of a normal prostate. I've since had a procedure called "Urolift" which allows me to fully empty my bladder.
If that is Trump's problem, then I would say, "Yeah, buddy, welcome to the club."
But if he's up at all hours of the night madly sending out tweets for some other reason, that's a different issue.