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Brain Cells Come Pre-Programmed, Challenging Century-Old ‘Blank Slate’ Theory

Landon Caeli

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"The human brain isn’t a blank slate waiting to be written by experience, according to research that challenges the century-old Tabula Rasa theory. The study shows that neurons grown in laboratory dishes spontaneously organize into precise firing sequences that resemble those seen in developing mouse brains, suggesting our neural circuits arrive pre-configured with computational architecture long before we experience the world.

The question of whether brains are shaped primarily by nature or nurture has occupied philosophers and scientists since at least the 17th century, when John Locke proposed the mind as a “tabula rasa” or blank slate. Modern neuroscience has largely assumed that while basic brain structures are genetically determined, the precise firing patterns that encode information must be learned through experience.

This study provides direct evidence against that"

 
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