Wuhan coronavirus (global health emergency)

tall73

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Health Minister Katsunobu Kato said on Saturday that Japan has entered a "new phase" of the outbreak.
A male doctor in his 50s in Wakayama Prefecture tested positive for the coronavirus on Thursday. Since then, eight more people in the prefecture, including patients at the doctor's hospital, have been infected. Troublingly, the Health Ministry says it has been unable to figure out where these transmissions originated.

The ministry says it has also been unable to identify infection routes for a man in his 60s in Aichi Prefecture, a man in his 20s in Chiba Prefecture, and a man in the northernmost prefecture of Hokkaido.

Until recently, officials were able to easily identify the transmission routes, as the majority of the infected had been among those the government flew back from Wuhan, the city at the center of the outbreak, or the passengers of the quarantined cruise ship docked near Tokyo.

What I gather from this is the virus is somehow established in Japan to some extent (small to be sure at the moment). Cases in Japan are appearing with no obvious link to China. Even worse than the source not being China, they don't seem to know what/where the source is, so how can they go about containing it?

That was what I was afraid of after the Hawaii story. There were only a few places they could have gotten it, most likely Japan. Sad news.

Many more may have already traveled abroad as they did. The lid is likely off now.
 
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tall73

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This article discusses possible origins of the virus' characteristics. They likewise note it is very unlikely to be engineered, and explain why. They also discuss possible unintentional release from a lab. It finds that the mutations were unlikely to be acquired during passage in culture.

The Proximal Origin of SARS-CoV-2


(i) natural selection in a non-human animal host prior to zoonotic transfer, and (ii) natural selection in humans following zoonotic transfer. We also discuss whether selection during passage in culture could have given rise to the same observed features.

Given the above, a release from a lab would likely only happen from housed animal specimens (alleged in the other article), and one of the two scenarios played out involving those animals. I suppose in theory exposure to the animals by an associated researcher in the field could also occur.
 
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Michael

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So what's the best case scenario that can take place with this possibility? And the worse case? Nobody knows? It seems to me the next 2-3 weeks the world could be in an absolute panic? Or maybe that things will show signs of coming around with less cases?

Freaking out about it isn't going to change anything, but based on the way it's spread thus far, it's pretty clear that this is going to be worldwide event that will have a pretty dramatic effect on the world economy as well as on human beings.

Japan will be a good test case in terms of how the coronavirus is likely to spread throughout the modernized world. There are enough cases there now to get a better handle on it's ability to spread.

More than 80 clinical trials launch to test coronavirus treatments

I think the best hope is that some of the treatments that are currently being tested eventually pan out and get widely distributed before the virus spreads too widely. It seems unlikely to me however that treatments will arrive in time to stop the virus before it has a worldwide impact.

The thing that's most interesting/troubling about this virus is it's ability to spread pretty quickly. The SARS virus was much easier to contain compared tot he coronavirus.
 
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Tanj

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Scientists ‘strongly condemn’ rumors and conspiracy theories about origin of coronavirus outbreak

A group of 27 prominent public health scientists from outside China is pushing back against a steady stream of stories and even a scientific paper suggesting a laboratory in Wuhan, China, may be the origin of the outbreak of COVID-19.

“We stand together to strongly condemn conspiracy theories suggesting that COVID-19 does not have a natural origin,” says The Lancet statement

The authors of The Lancet statement note that scientists from several countries who have studied SARS-CoV-2 “overwhelmingly conclude that this coronavirus originated in wildlife,” just like many other viruses that have recently emerged in humans. “Conspiracy theories do nothing but create fear, rumours, and prejudice that jeopardise our global collaboration in the fight against this virus,” the statement says.
 
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Michael

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This is also the same government that has arrested journalists and well as doctors who have tried to sound the alarm on the spreading of this virus, and which imprisons Muslims by the millions.

It would be quite the coincidence that the virus in question originated just 300 yards from a biological facility that just so happens to work on these kinds of genetic modifications.

It originated in wildlife alright, even if the animal in question was human. :)
 
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Tanj

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This is also the same government that has arrested journalists and well as doctors who have tried to sound the alarm on the spreading of this virus, and which imprisons Muslims by the millions.

None of the 27 authors on the paper you didn't even bother to read before responding to are Chinese, or are affiliated with the Chinese government.

It would be quite the coincidence that the virus in question originated just 300 yards from a biological facility that just so happens to work on these kinds of genetic modifications.

Oh well, if you are incredulous, it must be true. But just for the entertainment value, what don't you go ahead and lets us all know about the "kinds of genetic modifications" the institute works on.
 
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Michael

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None of the 27 authors on the paper you didn't even bother to read before responding to are Chinese, or are affiliated with the Chinese government.

I don't see what difference their nationality matters to start with, but OK, I'll bite, what makes 27 *non Chinese* authors (presumably without knowledge of the facts on the ground) more credible than two *Chinese* authors/scientists who came to the conclusion that it probably originated in one of two local labs, one within 300 yards of the epicenter of the outbreak? The one nearest the epicenter just so happens to have several hundred infected (with coronavirus) bats of the type that has the right genome, whereas "in the wild" bats of the same genome type live hundreds of miles away from the epicenter.

Oh well, if you are incredulous, it must be true. But just for the entertainment value, what don't you go ahead and lets us all know about the "kinds of genetic modifications" the institute works on.

Logistical and Technical Exploration into the Origins of the Wuhan Strain of Coronavirus (COVID-19)

– By 2015, conducting research that was met with an enormous amount of concern, scientists at UNC had successfully created a “chimeric, SARS-like virus” by altering the viral genome of a Chinese bat coronavirus’s spike-protein genes – sequences that code for the spikes that poke out from surface of viruses and allow them to unlock entry into hosts, in this case making the bio-engineered coronavirus incredibly contagious. This research raised eyebrows since it was clearly gain-of-function research – experimentation that seeks to increase a pathogen’s virulence, creating a more effective double-edged sword to counter – a practice banned in America from 2014 until December 2017 when NIH lifted the ban, specifically to allow research on this sort of virus. Looking at UNC’s gain-of-function research on coronavirus spike-proteins, which received its funding just before the ban was implemented and was only allowed to go forward following a special review, a virologist with the Louis Pasteur Institute of Paris warned: “If the [new] virus escaped, nobody could predict the trajectory.”

– But then oddly, in late January right as the pandemic was blooming, Dr. Ralph Baric claimed in an interview that people should be more concerned with the seasonal flu – despite having personally overseen the controversial engineering of a hyper-virulent strain of batty coronavirus just a few years back. Immediately discounting the burgeoning outbreak of an unknown coronavirus as a non-event seems particularly troubling for someone who’d trained two Chinese scientists on how to make hyper-virulent coronaviruses, especially when it’s hard to imagine that Dr. Baric was unaware his past colleagues were now working at the Wuhan Virology Lab, the epicenter of the outbreak. Highlighting the dissembling absurdity of this statement, based on reporting from the Chinese CDC: the Wuhan Strain COVID-19 appears to be twenty-times more lethal than the seasonal flu.

The lab at the epicenter of the outbreak was staffed by Chinese scientists that had worked directly on hyper-virulate strains of the coronavirus, based on spike protein genes as are now found in the COVID-19 strain. Pure coincidence in your opinion?

Oh, and let's not forget that the labs in China aren't exactly renowned for their safety track record.

And then there's the small problem regarding the fact that the first three coronavirus patients had no direct contact with the market that was named as the epicenter and the person identified as patient zero had no connection at all to that market.

 
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Jonathan Walkerin

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It would be quite the coincidence that the virus in question originated just 300 yards from a biological facility that just so happens to work on these kinds of genetic modifications.

So why do you think Trump administration has not made this public? I would presume the mighty US intelligence apparatus has even better information gathering then your average CF poster.

Then again looking at the statements coming out of the WH sometimes I wonder....

Anyway, Trump hates China, has a history of lying through his teeth about everything. So why would they not make this public and say it was a Chinese bioengineered virus if they had any shred of proof about it ?
 
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Michael

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So why do you think Trump administration has not made this public? I would presume the mighty US intelligence apparatus has even better information gathering then your average CF poster.

Then again looking at the statements coming out of the WH sometimes I wonder....

Anyway, Trump hates China, has a history of lying through his teeth about everything. So why would they not make this public and say it was a Chinese bioengineered virus if they had any shred of proof about it ?

I seriously doubt that Trump understands the first thing about science to start with, let alone has any understanding of genome therapies and viruses. Trump has routinely ignored and dismissed the information that was provided to him by the US intelligence services in favor of whatever propaganda that Putin tells him, so why would Trump trust US intelligence services when it comes to this issue?

Trump wants to be reelected which will require a strong economy come next November, so the very last thing that he needs is to have China implode economically and send the rest of the world into recession.

Besides, Trump didn't say a word about China's handling of Hong Kong, or it's rounding up of Muslims, so why in the world would he make any negative comments about them over this issue?

Even I'm not 100 percent convinced that the virus leaked out of a lab, and I sure as heck wouldn't make any public statements as the President of the US unless I was 100 percent sure, and even then there might be political and/or economic reasons for keeping my mouth shut.
 
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Jonathan Walkerin

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I seriously doubt that Trump understands the first thing about science to start with, let alone has any understanding of genome therapies and viruses. Trump has routinely ignored and dismissed the information that was provided to him by the US intelligence services in favor of whatever propaganda that Putin tells him, so why would Trump trust US intelligence services when it comes to this issue?

I have do doubt that he has no clue about science or foreign politics and fawns at dictators. This has been amply demonstrated.

But that is not his goal. He only needs to pamper his base. He is not worried about foreign relations, the future of US alliances or irrelevant stuff like that.

The economy will tank sooner or later. Already the crash is overdue. Want to bet when it inevitably happens China and their bioengineered virus plot to destroy US economy will be tweeted so fast trump`s fingers bleed.
 
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Michael

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I have do doubt that he has no clue about science or foreign politics and fawns at dictators. This has been amply demonstrated.

But that is not his goal. He only needs to pamper his base. He is not worried about foreign relations, the future of US alliances or irrelevant stuff like that.

The economy will tank sooner or later. Already the crash is overdue. Want to bet when it inevitably happens China and their bioengineered virus plot to destroy US economy will be tweeted so fast trump`s fingers bleed.

If the economy does crash before the election, I'd guess that you're absolutely correct that Trump will blame China and claim that it's a conspiracy to get a democrat elected because China is afraid of him being reelected and they would rather deal with a democrat. :)
 
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Kaon

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This is also the same government that has arrested journalists and well as doctors who have tried to sound the alarm on the spreading of this virus, and which imprisons Muslims by the millions.

It would be quite the coincidence that the virus in question originated just 300 yards from a biological facility that just so happens to work on these kinds of genetic modifications.

It originated in wildlife alright, even if the animal in question was human. :)

It's too scary to think about this!!! Can't be true!
 
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Kaon

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The economy will tank sooner or later. Already the crash is overdue. Want to bet when it inevitably happens China and their bioengineered virus plot to destroy US economy will be tweeted so fast trump`s fingers bleed.

Yes, the economy will have to "correct" itself soon, which is only one reason why Trump will remain in office.

This is how predictable we are: no matter how inept the president is, Americans will look the other way if a big enough distraction disaster comes along. W was just as, or even more inept than Trump in his first seven months of presidency - with plenty of scandal. 9/11 happens and he is "da man". Everyone forgets about what he did before.

This is what will happen in America; If something "scary" (natural or unnatural) happens, the people will look the other way on everything about Trump, and rally around him since he is the "leader" of the country. A financial collapse will keep Trump in office, and his shenanigans will be forgotten.

Then we can repeat the same past 1400 years of history again, and blame each generation after us for their ineptitude and social unconsciousness - like we do today. We don't actually learn; we adapt to the subjugation and then attack those who point it out - while the exploiters continue to make money off of our demise.
 
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Tanj

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I don't see what difference their nationality matters to start with

It shows that your "the Chinese government is totalitarian" response to my post is irrelevant.

but OK, I'll bite, what makes 27 *non Chinese* authors (presumably without knowledge of the facts on the ground)

"presumably" huh? On what basis, is it because they disagree with you? At any rate, their decision is based on the results of various biochemical, genetic and epidemiological tests that have been run on the virus. I thought you were a huge fan of "evidence from a lab" . The fact you don't understand the biology or the experiments doesn't make them any less evidential.

more credible than two *Chinese* authors/scientists who came to the conclusion that it probably originated in one of two local labs, one within 300 yards of the epicenter of the outbreak?

Because their conclusion, like yours, was based on evidenceless speculation and incredulity.

The one nearest the epicenter just so happens to have several hundred infected (with coronavirus) bats

Says who? What evidence do you have that Wuhan keeps bats, let alone infected ones? Let me guess...your complete lack of knowledge about how virus research is done has lead you to conclude they must.

of the type that has the right genome

What? What does that mean. What is the "right genome"? What evidence do yoiu have that they have it?

whereas "in the wild" bats of the same genome type live hundreds of miles away from the epicenter.

Your knowledge of bat ecology is as deep as your general biology. Excellent.


The lab at the epicenter of the outbreak was staffed by Chinese scientists that had worked directly on hyper-virulate strains of the coronavirus

No, it isn't. You just made that up.

based on spike protein genes as are now found in the COVID-19 strain. Pure coincidence in your opinion?

Pure fantasy and unevidenced speculation.


And then there's the small problem regarding the fact that the first three coronavirus patients had no direct contact with the market that was named as the epicenter and the person identified as patient zero had no connection at all to that market.

So what? how does not knowing the original site of infection relate to the mountain of biological experiments that show the virus did not come from a lab?
 
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Michael

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It shows that your "the Chinese government is totalitarian" response to my post is irrelevant.

No, although you might rightly suggest that it's irrelevant to the one specific article that you cited. This is however the very same government that actively forbids any discussion at all about Tienanmen square and which routinely forbids the free exchange of information whenever it's inconvenient for them, locks up people indiscriminately, and routinely removes and blocks access to all information that's inconvenient to them. I therefore have *little if any* confidence in anything that the Chinese government has to say about the origin of the virus.

"presumably" huh? On what basis, is it because they disagree with you?

No, because they aren't living in China or living near the epicenter of the virus and they don't necessarily know anything about the city in question, the facilities that it contains, or the biological work that's being done there. The authors of the paper (now banned in China) did understand the facilities in question, the work that's being done there, and the relevance to the virus in question. Did you bother to even read their paper? Yes or no? I would have to guess that the answer is "no" based on the other questions your asked below. That might explain our differences in belief by the way.

At any rate, their decision is based on the results of various biochemical, genetic and epidemiological tests that have been run on the virus. I thought you were a huge fan of "evidence from a lab" . The fact you don't understand the biology or the experiments doesn't make them any less evidential.

As far as I can tell from the letter and papers that I've read, the evidence amounts to "it could originate in the wild, therefore it probably did". That's not direct empirical evidence to support the claim that it *had* to originate in the wild, that's simply an obvious fact. It "could" evolve naturally just like virtually all biological entities could evolve naturally. That's still not evidence that it necessarily *did* evolve naturally.

Because their conclusion, like yours, was based on evidenceless speculation and incredulity.

Be a bit more specific. Which *specific* evidence did you find to be the most compelling evidence that it evolved naturally because you and I clearly didn't seem to read the "evidence" the same way.

Says who? What evidence do you have that Wuhan keeps bats, let alone infected ones? Let me guess...your complete lack of knowledge about how virus research is done has lead you to conclude they must.

I can only assume from that particular question that you never bothered to read the paper by the two Chinese scientists that made the original claim, nor any of links that I've posted to this thread. From the published paper now banned in China:

The bats carrying CoV ZC45 were originally found in Yunnan or Zhejiang province, both of which were more than 900 kilometers away from the seafood market. Bats were normally found to live in caves and trees. But the seafood market is in a densely-populated district of Wuhan, a metropolitan of ~15 million people. The probability was very low for the bats to fly to the market. According to municipal reports and the testimonies of 31 residents and 28 visitors, the bat was never a food source in the city, and no bat was traded in the market. There was possible natural recombination or intermediate host of the coronavirus, yet little proof has been reported. Was there any other possible pathway? We screened the area around the seafood market and identified two laboratories conducting research on bat coronavirus. Within ~280 meters from the market, there was the Wuhan Center for Disease Control & Prevention (WHCDC) (Figure 1, from Baidu and Google maps). WHCDC hosted animals in laboratories for research purpose, one of which was specialized in pathogens collection and identification 46. In one of their studies, 155 bats including Rhinolophus affinis were captured in Hubei province, and other 450 bats were captured in Zhejiang province 4. The expert in collection was noted in the Author Contributions (JHT). Moreover, he was broadcasted for collecting viruses on nation-wide newspapers and websites in 2017 and 2019 7,8. He described that he was once by attacked by bats and the blood of a bat shot on his skin. He knew the extreme danger of the infection so he quarantined himself for 14 days 7. In another accident, he quarantined himself again because bats peed on him. He was once thrilled for capturing a bat carrying a live tick 8. Surgery was performed on the caged animals and the tissue samples were collected for DNA and RNA extraction and sequencing 4, 5. The tissue samples and contaminated trashes were source of pathogens. They were only ~280 meters from the seafood market. The WHCDC was also adjacent to the Union Hospital (Figure 1, bottom) where the first group of doctors were infected during this epidemic. It is plausible that the virus leaked around and some of them contaminated the initial patients in this epidemic, though solid proofs are needed in future study.

Had you actually read their paper, you'd already know the answer to your question.

What? What does that mean. What is the "right genome"? What evidence do yoiu have that they have it?

Virtually all the papers agree that the virus shares 80-99 percent of the genes with a specific virus from a specific bat. I only know from the paper that such bats were intentionally collected and studied at the laboratory in question.

Your knowledge of bat ecology is as deep as your general biology. Excellent.

FYI, I've never claimed to be a biological weapons expert, but I do understand the basics of genetic science, DNA, and the fact that genes can easily be manipulated. That's all anyone really *needs* to know to understand what is possible and what is not possible with respect to this issue.

I also know from the articles that I cited for you that at least two Chinese scientists that were involved in US genetic manipulation of the coronavirus were also working in the lab near the epicenter of this virus outbreak and their work in the US was directly related to producing a highly contagious version of the virus via "gain-of-function research".

No, it isn't. You just made that up.

No, I did not. I cited the specific article and the the appropriate paragraph of my source and it even names the individuals.

Given that this outbreak was said to begin in late December when most bat species in the region are hibernating and the Chinese horseshoe bat’s habitat covers an enormous swath of the region containing scores of cities and hundreds of millions people to begin with, the fact that this Wuhan Strain of coronavirus, denoted as COVID-19 emerged in close proximity to the only BSL-4 virology lab in China, now notoriously located in Wuhan, which in turn was staffed with at least two Chinese scientists – Zhengli Shi and Xing-Yi Ge – both virologists who had previously worked at an American lab which already bio-engineered an incredibly virulent strain of bat coronavirus – the accidental release of a bio-engineered virus meant for defensive immunotherapy research from Wuhan’s virology lab cannot be automatically discounted, especially when the Wuhan Strain’s unnatural genomic signals are considered.

Emphasis mine.

Pure fantasy and unevidenced speculation.

Again, I provided you with the relevant sources, and it's neither fantasy nor unevidenced speculation, it's *published fact*. If you won't read the references I cited, that's your fault, not mine.

So what? how does not knowing the original site of infection relate to the mountain of biological experiments that show the virus did not come from a lab?

The evidence you cited (or that I cited) doesn't definitely point to any particular point of origin, and the source listed by the Chinese government has been eliminated as the point of origin for the first three reported cases, as well as for "patient zero".

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30154-9/fulltext

Two complete virus genomes (HKU-SZ-002a and HKU-SZ-005b) were sequenced using Nanopore technology and showed a novel coronavirus that is most closely related to those of the bat SARS-like coronavirus bat-SL-CoVZXC21 (NCBI accession number MG772934) and bat-SL-CoVZC45 (NCBI accession number MG772933).

Now it's still not certain that the specific ACE2 binding changes that are found in this new virus were produced in a lab, or they simply occurred "naturally" (without a leak from a lab), but it's clear that the basic genome is closely related to specific type of bat viruses that are found *hundreds* of miles from the epicenter of the outbreak, and only about 280 yards from a lab that is known to have collected and experimented with such bats.

Again, as I have already explained in this thread, I am not 100 percent certain that the virus was accidentally leaked from a lab, but I certainly cannot rule out that possibility either given the specific circumstances, and the *very* close proximity of biological laboratories within mere yards of the epicenter of the outbreak.
 
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Tanj

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No, although you might rightly suggest that it's irrelevant to the one specific article that you cited.

The one that was the entire point of my post, that one?

This is however the very same government

And there you go again, tilting at exactly the same windmill that has nothing to do with my posts. Biologists unaffiliated in any way with the Chinese government have performed experiments that disprove any kind of lab leak. It doesn't matter what a bunch of Chinese government people say. It's about what the science says.

I therefore have *little if any* confidence in anything that the Chinese government has to say about the origin of the virus.

For the umpteenth time, I am in no way using even the slightest hint of a whiff of anything from anything Chinese related (except, obviously, for the virus itself).

Why is that so hard for you to understand?

No, because they aren't living in China or living near the epicenter of the virus and they don't necessarily know anything about the city in question, the facilities that it contains, or the biological work that's being done there

Utterly, utterly utterly irrelevant. Viral genetics and biology experiments do not require any of that information. I have deleted my somewhat acerbic responses to most of the rest of your post, but the bottom line is that using your dislike of the Chinese government as a basis for decision making on this topic is nonsensical. This is a virology question, and is answered by actual virology, not your inability to accept the unlikeliness of an outbreak occuring near a lab.

Actual science.

The authors of the paper (now banned in China) did understand the facilities in question, the work that's being done there, and the relevance to the virus in question. Did you bother to even read their paper? Yes or no?

Of course I did.

I would have to guess that the answer is "no" based on the other questions your asked below. That might explain our differences in belief by the way.

Nope, the difference is that my PhD is in viral epidemiology and I have a full and complete understanding of all of the work involved, and you are a layman who thinks it's all about the non scientific anecdotes.

It isn't.


Be a bit more specific. Which *specific* evidence did you find to be the most compelling evidence that it evolved naturally because you and I clearly didn't seem to read the "evidence" the same way.

Sure. Here you go:

Direct link to actual evidence:
The Proximal Origin of SARS-CoV-2

Indirect link to a whole bunch more
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30418-9/fulltext



Virtually all the papers agree that the virus shares 80-99 percent of the genes with a specific virus from a specific bat. I only know from the paper that such bats were intentionally collected and studied at the laboratory in question.

The were not collected. That's not how this research is done.

FYI, I've never claimed to be a biological weapons expert, but I do understand the basics of genetic science, DNA, and the fact that genes can easily be manipulated.

No, you don't.
 
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tall73

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Direct link to actual evidence:
The Proximal Origin of SARS-CoV-2

I discussed this study earlier, and noted that it shows the unpredictable effectiveness of this particular mutation, as evidence that it was not lab created.

However, with your expertise, could you explain a few things that I am not understanding.

a. Could those collecting the specimens across China be infected by direct contact with bats if they have this coronavirus, which could then play out in either of the two scenarios that they mention in the paper?

b. It notes that the mutation occurring in passage are quite unlikely. Can the samples themselves cause transfer, or does that require the live bat?

c. Does this earlier study not show chimeric combinations of backbone cov SARS with another Coronavirus with the SHCO14 spike? You seemed to indicate such was not going on, or perhaps I misunderstood what you stated.

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

Thus, relative to the Urbani spike–MA15 CoV, SHC014-MA15 shows a gain in pathogenesis (Fig. 1). On the basis of these findings, scientific review panels may deem similar studies building chimeric viruses based on circulating strains too risky to pursue, as increased pathogenicity in mammalian models cannot be excluded. Coupled with restrictions on mouse-adapted strains and the development of monoclonal antibodies using escape mutants, research into CoV emergence and therapeutic efficacy may be severely limited moving f
orward.


The SHCO14 spike appears to be naturally occurring, which of course suggests that various others could be naturally occurring, including the nCov 19 strain, which could allow for direct transfer as suggested in the article?

Here is a discussion of the article:

David R. Liu on Twitter

The analysis at the end of the paper notes that NCov19 and SCH014 are different, and interact with the Ace 2 differently.



The closest to the ncov19 was BatCov RatG13, from Yunnan province.
https://www.nature.com/articles/s41586-020-2012-7_reference.pdf

We then found a short RdRp region from a bat coronavirus termed BatCoV RaTG13 which we previously detected in Rhinolophus affinisfrom Yunnan Province showed high sequence identity to 2019-nCoV.

Which suggested the bat origin.


The significance of the study out of the Bejing South China Institute of Technology seemed to be that there were not these sorts of bats in the area of Wuhan, or sold in the market.

That, combined with the information that a number of initial cases did not appear to come from the market, seems to be the basis of theories that the lab was involved. It was the closest source of any of the bat materials that seem to be implicated.

Unless that study was wrong on the presence of bats in the immediate area.
 
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tall73

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Evidence found of multiple mini-outbreaks of various Coronavirus types in surveys of villagers, from direct contact with bats.

New Research: Bats Harbor Hundreds Of Coronaviruses, And Spillovers Aren't Rare

She and her colleagues checked the villagers' blood for signs of recent infections with bat coronaviruses. The team did this again with people in some other rural areas. Each time, says Li, "we found coronaviruses that had already spilled over into the human population."

These were multiple mini-outbreaks that had gone undetected.

Olival says this discovery was a huge red flag: "The signal is there that these SARS-related viruses were jumping into people even if they weren't causing any noticeable disease."

Indeed, people might have even had symptoms, but health authorities simply never picked up on it.

 
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Tanj

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I discussed this study earlier, and noted that it shows the unpredictable effectiveness of this particular mutation, as evidence that it was not lab created.

However, with your expertise, could you explain a few things that I am not understanding.

I can try....

a. Could those collecting the specimens across China be infected by direct contact with bats if they have this coronavirus, which could then play out in either of the two scenarios that they mention in the paper?

Ever been in a bat cave? lol. The short answer is it is unlikely. The conditions in these caves are so horrible that the people that go into them are suited up. Pretty sure there's photos of on the web somewhere... here we go
https://nationalpost.com/news/world...t-identical-to-the-one-killing-hundreds-today

The other thing to consider is that they don't go into caves during "coronavirus season", because that's not a thing. Chances are that 1 bat in 100?? is carrying anything that could be transmitted to anything, including another bat.

Having said all of that, sure, it's possible a researcher went into a cave, picked up a virus, then spread it into the community. Not sure that counts as accidental leak from a lab.

b. It notes that the mutation occurring in passage are quite unlikely. Can the samples themselves cause transfer, or does that require the live bat?

It actually says that certain types of mutations are unlikely. Passage mutations are common, but, for instance, the kinds of mutations caused by immune pressure don't happen when you passage in cell lines.

Virus is virus, it just needs the correct route of entry. Depending on what manipulations you are performing, there is a lesser or greater chance of infecting yourself. With a respiratory virus you would need it to be aspirated/aerosoled in such a way as to breathe it in. (injecting yourself in this case would have no effect because a respiratory virus doesn't know what to do when in the blood). It's not very likely, largely because any situation where the virus can get into you is a situation where bits of the environment can get into the virus sample and contaminate it, airborne bacteria and fungi being the worst culprits. The kind of bench scientist that goes around contaminating his samples on a regualr basis doesn't stay a bench scientist. It's the kind of behaviour that you train against until it's pretty much reflex, and laminar flow hoods also reduce these risks.

b. Does this earlier study not show chimeric combinations of backbone cov SARS with another Coronavirus with the SHCO14 spike? You seemed to indicate such was not going on, or perhaps I misunderstood what you stated.

The research you described in the bit I didn't quote is from known coronaviruses. The RBD in the NKOTB is entirely novel. It's not possible that anyone intentionally built a chimera of a virus using pathogenitc determinants that no-one knew about nor could predict.

The analysis at the end of the paper notes that NCov19 and SCH014 are different, and interact with the Ace 2 differently.

Right. Viruses are tricksy.

The closest to the ncov19 was BatCov RatG13, from Yunnan province.
https://www.nature.com/articles/s41586-020-2012-7_reference.pdf


Indeed, though "close" is a relative term, that virus is 10-15 years separated from ncov19.

Which suggested the bat origin.

Well, it certainly puts bats on the radar. I wouldn't be surprised if it was a bat, but we cannot rule out could be another species, there's some talk around Malaysian imported pangolins.

I apologise for this not reputable science link but I am short on time...
Pangolin May Be a Vector for Chinese Coronavirus


"After testing more than 1,000 samples from wild animals, scientists from the university found the genome sequences of viruses found on pangolins to be 99% identical to those on coronavirus patients, the official Xinhua news agency reported."

That, combined with the information that a number of initial cases did not appear to come from the market, seems to be the basis of theories that the lab was involved. It was the closest source of any of the bat materials that seem to be implicated.

I'd argue fear and clickbait headlines ARE the basis for the ONGOING theories that the lab is involved. Look at the responses in this very thread from Michael. His distrust of the Chinese government added to his personal incredulity at an outbreak near a lab not involving the lab means he cannot be convinced otherwise by any source of data.

A final word on bats...

Indooroopilly island, which is a few kms from the Brisbane CBD, is home to several hundred thousand bats, which can forage over 100kms. The idea that bats suat timidly in caves far from humans is not correct.
indooroopilly island bats - Google Search
 
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