Hans Blaster
On August Recess
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A macroevolution physical rather than genetic change is for example how a three chamber heart became four. THe problem is the replumbing. The flows , timings and sequences have to reverse. It is not adequate explanation to propose a vestigial chamber to gradually gain more significance. A surgeon would struggle to keep a patient alive undertaking such an operation reversing of flows. So how did blind variation do this?
You might need to work on your Google-fu, Mike.
This was one of several articles I found while searching for the evolution of the four-chambered heart.
Secrets of the Four Chambers Revealed by Reptile Hearts
It focuses on the discovery of the molecular factors involved in the development of four-chambered relative to three-chambered hearts, including noting that their is a partial septum in the 3.5-chambered turtle heart that shows effects from the same transcription factor.
For additional discussion search "evolution four chambered heart".
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