Generally speaking, they don't. Creationist explanations of nature offer almost nothing value in understanding the properties of reality and rarely, if ever, have any predictive power.
Science actually has a lot to say on the subject - it's been an active topic of research for almost 100 years, since Alexander Oparin started actively publishing biochemistry papers in the 1920s.
Science is a methodology that we use to derive explanations. Creationism is just fiat assertion that a being did a thing.
Science may never answer either question to our complete satisfaction. However, there is a vast difference between explaining the origin of our local presentation of space time, and the development of self-replicating biological systems from earlier abiotic molecules.
Seeking to conflate the two, seemingly just because they're linked in your favoured creation story, is a folly.
Hi there pita bread!
Please remember that words on a post like this do not disseminate tone nor inflection, and that I am attempting to inspire thinking on your part as opposed to shooting you down
Alexander Oparins work never resulted in any theory? Yes scientists are assuming to apply the scientific method of inquiry to the origin of life but that has yielded nothing so far of value. In fact, the more recent discovery of biological information in DNA is much more compelling when it comes to tweaking our hypothesis that there was a level of agency involved (unless you assume the self defeating stance that science can explain everything?).
Thats because information is best explained from the top down (mind) as opposed to bottom up(random mutation and natural selection). (just try an explain the information(semiotics) on a menu in a restaurant in terms of the ink on the paper!)
And let me explain something that eludes most people right off the bat:
The Theory of evolution or any theory of the origin of life is not science (read scientific method).
Let me be specific, the theory of evolution was not reached by conducting experiments of observation and repeatability. The scientific method as a method of inquiry is not available at all when it comes to trying to explain the level of biological complexity we witness on the planet. Darwin had a friend, Lyell,
The theory of evolution is a philosophical one. Inference as to the best explanation. Just like forensic science is a philosophical endeavour. You get a crime scene, no one observed the murder, and you can't repeat it, so now what.
Well you shift from deduction to induction (inference). A strand of hair on its own is not compelling in any way, but throw in a thumb print and a blood spatter and a foot print, and all of a sudden the cumulative force of the evidence becomes compelling. Because of reasoning and evidence.
when you say:
Generally speaking, they don't. Creationist explanations of nature offer almost nothing value in understanding the properties of reality and rarely, if ever, have any predictive power.
You are missing the point. Creationism is based on reason and evidence (here we appeal to history and science to support our philosophical inferences), it is most certainly not an assertion? The same applied to the beginning of the universe, and well, the parallels between the bible and what science has discovered over the last 100 years is remarkable!
A good example to hit home with on all of this is to ask someone:
"Choose one of the following that best explains the law of internal combustion:
1. the motor car or
2.Henry Ford"
The one answer is at the level of a mechanism, and the other at the level of an agent. You simply need both, and they in no way conflict with each other.
when you say:
Seeking to conflate the two, seemingly just because they're linked in your favoured creation story, is a folly.
This tells me that you are not properly distinguishing between origin science and operation science.
The two events that i cited are related in that they both fall under origin science. the scientific method can be applied to things already in motion (operation science), but trying to apply it to something that no one observed and that can't be repeated is useless.
I am getting the sense that you are not engaging on the various evidences for the evidence of God, and dismissing the bible as a story as a result?
If you are agnostic, i would encourage you to seek out the truth with an inquiring mind. i am happy to help and or point you to resources to help out

once you understand philosophy and have gone through the various evidences then you can come to your own conclusion. But at the very least it will be demonstrated to you that being a Christian is a reasonable and rational position to hold, as opposed to your current view point on Creationists.
Creationism, not science, is the best explanation for the origin of life, and the origin of the universe too.
Kind regards,
T