• Starting today August 7th, 2024, in order to post in the Married Couples, Courting Couples, or Singles forums, you will not be allowed to post if you have your Marital status designated as private. Announcements will be made in the respective forums as well but please note that if yours is currently listed as Private, you will need to submit a ticket in the Support Area to have yours changed.

Can an old earth be proven?

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
I think the only piece worth responding to is number 2.

"2. OK let's say those statements do not contradict on another. But would you agree that to make the statement not contradict to each other, the benifitial mutation fixation decline must be more than the decline in fitness acceleration? No matter what, both are flatlining, and do you have doubt that those cells would not grow to the size of a football (even in a million years)?"

Well, firstly...

"
In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable."

This is straight from the abstract ^ of the 2009 paper.

And in Figure 2, there is a diagram up to 20,000 generations in which mutation rates appear uniform.

And I am reading segments of the more recent paper written by 60,000 generations (Their October 2017 paper), and they are discussing the same thing. This, surprising prevalence of beneficial mutations even at later generations. The linear rate of increased fitness appears to still be driving a steady rate of beneficial mutations.

So, I think that...well, I will await your response to this^.


In theory, both should eventually flatline in a stable environment. Without new environmental stresses to fixate beneficial mutations, eventually, i would imagine they would both flatline. If growing the size of a football, were the position of optimal fitness for their test tube environment, then they would hypothetically grow that big, even if it took a million years.
 
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
Why would you quote an early research when the 2013 research (which is newer than the research you quoted) clearly states that fixation of beneficial mutations are getting progressively lower?

I think the only piece worth responding to is number 2.

"2. OK let's say those statements do not contradict on another. But would you agree that to make the statement not contradict to each other, the benifitial mutation fixation decline must be more than the decline in fitness acceleration? No matter what, both are flatlining, and do you have doubt that those cells would not grow to the size of a football (even in a million years)?"

Well, firstly...

"
In particular, beneficial substitutions were surprisingly uniform over time, whereas neutral substitutions were highly variable."

This is straight from the abstract ^ of the 2009 paper.

And in Figure 2, there is a diagram up to 20,000 generations in which mutation rates appear uniform.

And I am reading segments of the more recent paper written by 60,000 generations (Their October 2017 paper), and they are discussing the same thing. This, surprising prevalence of beneficial mutations even at later generations. The linear rate of increased fitness appears to still be driving a steady rate of beneficial mutations.

So, I think that...well, I will await your response to this^.


In theory, both should eventually flatline in a stable environment. Without new environmental stresses to fixate beneficial mutations, eventually, i would imagine they would both flatline. If growing the size of a football, were the position of optimal fitness for their test tube environment, then they would hypothetically grow that big, even if it took a million years.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
Why would you quote an early research when the 2013 research (which is newer than the research you quoted) clearly states that fixation of beneficial mutations are getting progressively lower?

Can you quote that? It's called, confirming details.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
"No matter what, both are flatlining, and do you have doubt that those cells would not grow to the size of a football (even in a million years)"
@dcalling

I think that, the idea of reaching a peak fitness is inevitable in a stable environment. And with that, fixed mutations also ought to ultimately end upon reaching a peak fitness. This would not mean an end to mutations however, rather just a final state of fitness that is the best it could be in its environment.

Though, as mentioned before, in the real world beyond a stable petri dish, reaching peak fitness would be an indefinite process, as there is no such thing as peak fitness in an ever changing complex world.

But in a stable environment, if peak fitness were represented by football sized e.coli, then they would feasibly reach that size, even if it took a million years, or a billion, or even a trillion.

I'll await your response to this. I am not sure what is remaining to be discussed. Seems like we have simply come to the conclusion that evolution happened.

The dynamics of molecular evolution over 60,000 generations
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
@dcalling

And regarding this

"the benifitial mutation fixation decline must be more than the decline in fitness acceleration?"

I would suggest that, if you believe you have a point to be made in this statement, you should present your conclusions of it. For example, you could say "I believe the rate of fixation should decline more than the rate of fitness improvement because X" and "I believe the declining rate of fitness improvement should not be greater than the rate of declining fixation because Y".

If there are mutations, then there is variation. If there are environmental stresses, then the stresses act on that variation, resulting in a collective increased fitness of clades and fixation of mutations within them.

As each population moves toward peak fitness, beneficial mutations fixate at a lower rate, as beneficial mutations are out-performed by even greater co-existing beneficial mutations.

In the research paper, it appears as though the decline in fitness improvement, is greater than the decline in mutation fixation. It states that fitness improvement, with clarity, decreases. While "The pace of molecular evolution has remained rapid throughout the experiment, even as the rate of fitness improvement has declined" only "declining modestly" over time from 20 mutations at 10k generations, to 10 mutations by 60k.

So to answer your question, based on the above, I would say that it is incorrect to suggest that the rate of mutation fixation must decline at a greater rate than the rate of decline of fitness acceleration.
 
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
Can you quote that? It's called, confirming details.

"A 2013 study by Wiser et al. reported ongoing improvement at 50,000 generations relative to samples isolated at 40,000 generations. They found that the fitness increase fit to a power law model much better than the hyperbolic models that had been used earlier. As a power law model describes an ever-slowing increase that has no upper limit, while a hyperbolic model implies a hard limit, the work suggested that the increase would continue without bound as progressively lower benefit mutations were fixed in the populations"

See how this reversed 2009 research on both sides (now fitness up but fixation of benifit mutations now down).
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
"A 2013 study by Wiser et al. reported ongoing improvement at 50,000 generations relative to samples isolated at 40,000 generations. They found that the fitness increase fit to a power law model much better than the hyperbolic models that had been used earlier. As a power law model describes an ever-slowing increase that has no upper limit, while a hyperbolic model implies a hard limit, the work suggested that the increase would continue without bound as progressively lower benefit mutations were fixed in the populations"

See how this reversed 2009 research on both sides (now fitness up but fixation of benifit mutations now down).

Sorry, and could you quote the specific passage from the 2009 research, just so we can see the two quotes side by side?

Thanks
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
I think I see what you are pointing out now.

The wiki article is citing a near linear rate of mutation, well, its from wikipedia so i think it leaves out some details. Basically, in the 2009 paper, mutations were apparently linear, or were declining at such a steady rate, that more time was needed to observe the decline of fixed beneficial mutations. In the research paper itself, they actually propose 3 different scenarios, two of which involves a decrease in rate of accumulated beneficial mutations.

Then the 2017 paper, the decrease in rate of accumulated mutations is more apparent, in that 20 are noted in the first 10,000, and 10 noted in the last 10,000.

So the wikipedia article is accurate in that it is pointing out how fitness steeply drops off in its increase , while accumulated mutations persists (which is significant because it wasn't predicted to happen) at what appeared to be a linear rate of accumulation, but this statement was based on limited data and doesn't describe the actual research paper in detail.

The point of interest is, why would these organisms keep accumulating fixed mutations at such a...near-linear rate, when the rate of improving fitness is declining much more rapidly.

We can explore the relationship between rates of adaptation and
genomic evolution under three scenarios. In the first, the substitution
of any beneficial mutation has no effect on either the selection coefficient,
S. ur the beneficial mutation rate, v. The rates of fitness
improvement and genome evolution should therefore be constant
over the long term. Under the second scenario, the number of possible
sites for beneficial mutations is finite, so that v declines with
increasing prior substitutions. The expected wait for a beneficial
mutation becomes progressively longer, and the trajectories for
adaptation and genomic evolution should decelerate in parallel. In
the third scenario, the advantage of new beneficial mutations declines
as fitness increases.
Under all three scenarios, this model thus predicts declining rates
of both adaptive and genomic evolution or, alternativcly, no deceleration
in either trajectory.
 
Last edited:
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
I think I see what you are pointing out now.

The wiki article is citing a near linear rate of mutation, well, its from wikipedia so i think it leaves out some details. Basically, in the 2009 paper, mutations were apparently linear, or were declining at such a steady rate, that more time was needed to observe the decline of fixed beneficial mutations. In the research paper itself, they actually propose 3 different scenarios, two of which involves a decrease in rate of accumulated beneficial mutations.

Then the 2017 paper, the decrease in rate of accumulated mutations is more apparent, in that 20 are noted in the first 10,000, and 10 noted in the last 10,000.

So the wikipedia article is accurate in that it is pointing out how fitness steeply drops off in its increase , while accumulated mutations persists (which is significant because it wasn't predicted to happen) at what appeared to be a linear rate of accumulation, but this statement was based on limited data and doesn't describe the actual research paper in detail.

The point of interest is, why would these organisms keep accumulating fixed mutations at such a...near-linear rate, when the rate of improving fitness is declining much more rapidly.

We can explore the relationship between rates of adaptation and
genomic evolution under three scenarios. In the first, the substitution
of any beneficial mutation has no effect on either the selection coefficient,
S. ur the beneficial mutation rate, v. The rates of fitness
improvement and genome evolution should therefore be constant
over the long term. Under the second scenario, the number of possible
sites for beneficial mutations is finite, so that v declines with
increasing prior substitutions. The expected wait for a beneficial
mutation becomes progressively longer, and the trajectories for
adaptation and genomic evolution should decelerate in parallel. In
the third scenario, the advantage of new beneficial mutations declines
as fitness increases.
Under all three scenarios, this model thus predicts declining rates
of both adaptive and genomic evolution or, alternativcly, no deceleration
in either trajectory.

I think there are some misunderstanding on this and need to clarify.

1. Your statement about "in the 2009 paper, mutations were apparently linear" is correct as I understand from the wiki page. But the quote above (is that from the 2009 paper?) seems to state some scenarios that are not totally compatible.
2. The 2013 research, quoted directly from wiki "A 2013 study by Wiser et al. ....as progressively lower benefit mutations were fixed in the populations" So this is from a different researcher that give an opposite conclusion with both the 2009 paper and the 2017 paper (which is from the same author of the 2009 paper).
Then the 2017 paper pretty much state the same as the 2009 paper.

However from the actual quote on the paper (above, your quote, 2009 paper?), it seems the author themselves is not sure which way it should go? I wonder what the actual observed result is, i.e. what's the max diffeerrence between current generation DNA and ancestral strain is, what's the mean, and it will be great if we could have a histogram of the variations vs time and size.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
1. That's correct, the 2009 paper proposes different potential outcomes. Things that could only be confirmed by future testing. It proposes that fixed mutations may decline in two of it's proposals. But again, only future testing could confirm which scenario were true.

2. In the 2013 document, it appears as though more data is available to confirm a decline in rate of fixed mutations. Which coincides with the 2009 paper "this model thus predicts declining rates of both adaptive and genomic evolution"

This 2017 research confirms declining rates of fixed mutations.

And yes the 2009 research indicates that the authors were uncertain of how things would unfold, but that's why they do the test, to reach a conclusive answer. The reason the test is done, is to learn how evolution works, so the test begins in 2009 with proposals of how it may happen because they were unsure.
However in 2009 they had enough data to say "hey the mutations appear steady while fitness declines" but only future tests can confirm whether mutations decline or not.
 
Last edited:
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
1. That's correct, the 2009 paper proposes different potential outcomes. Things that could only be confirmed by future testing. It proposes that fixed mutations may decline in two of it's proposals. But again, only future testing could confirm which scenario were true.

2. In the 2013 document, it appears as though more data is available to confirm a decline in rate of fixed mutations. Which coincides with the 2009 paper "this model thus predicts declining rates of both adaptive and genomic evolution"

This 2017 research confirms declining rates of fixed mutations.

And yes the 2009 research indicates that the authors were uncertain of how things would unfold, but that's why they do the test, to reach a conclusive answer. The reason the test is done, is to learn how evolution works, so the test begins in 2009 with proposals of how it may happen because they were unsure.
However in 2009 they had enough data to say "hey the mutations appear steady while fitness declines" but only future tests can confirm whether mutations decline or not.

It still sounds very strange, that in 2009 they declare "hey the mutations appear steady while fitness declines", and yet in 2013 another team with pretty much the same data arise almost the opposit conclusion. Then in 2017 they sort of re-iterated their 2009 position (but without the real paper I can't be sure if they are still flip-floping with different theories in their 2017 paper).

It will be really nice to see the actual data, as you can see different scientists can arrive to different positions based on the same set of data.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
It's the same lead scientist in each research paper, and they aren't flip flopping and they aren't reaching opposite conclusions. Their conclusions do not contradict one another.

In 2009 they proposed the possibility of declining fixation, in 2013 and in 2017 they confirmed this. There is no contradiction. You should read the papers.
 
Last edited:
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
2008 Research Authors
-----------------------------

2013 Research Authors
-------------------------
Long-Term Dynamics of Adaptation in Asexual Populations
  1. Michael J. Wiser1,2,
  2. Noah Ribeck1,3,
  3. Richard E. Lenski1,2,3,*
2017 Research Authors
---------------------------
llenjamfilH. Cood1•2.J.•.s•, Michael J. McDonald1·2·6•, Jeffrey E. Barrick7•8, Richard E. Lenski8•9 & Michael M. Desai1•2·~

Perfection is a myth, show 50,000 bacterial generations

"In 1988, Richard Lenski of Michigan State University in East Lansing began growing 12 cultures of the same strain of Escherichia coli bacteria. The bacteria have been growing ever since, in isolation, on a simple nutrient medium – a total of more than 50,000 E. coli generations to date.

Every 500 generations, Lenski freezes a sample of each culture, creating an artificial “fossil record”. This allows him to resurrect the past and measure evolutionary progress by comparing how well bacteria compete against each other at different points in the evolutionary process."



Lenski is taking lead, his co authors and assistants are rotated. Still the same university, same subjects, orchestrated by the same lead researcher.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
@dcalling

You keep making false statements over and over again, yet you aren't even acknowledging them. Below, I have listed a handfull.

"If the mutations are really beneficial, why are they stopped fixation? "
They haven't stopped.

You state that research conclusions contradict one another, but they don't.

You claim that it is different researchers reaching different conclusions, yet its the same lead author and researcher, reaching conclusions that align with one another.

"I never said 66k generation is enough to evolve limbs, I simply state the fact that after 66k generations, fixed benifitial mutations are slowing down, instead of as you stated they should keep accumulating."

There is a difference between stating that all mutations will magically stop, and stating that in a fixed and stable environment (which only exists in a laboratory), mutations will stop fixating.

You stated "Which means there is a mutation limit, at least with our current knowledge of genes, that there is finite number of mutations at different points."

A finite number of mutations at different points, however, as seen in these research papers, that number of points and that number of combinations of points, is extraordinarily vast in number, to the extent that after 60,000 generations the subjects have undergone tens of billions of genetic changes, and are still undergoing mutation and continued genetic and phenotypic variation. And this is further in a fixed and stable environment that opposes fixation.

"are progressively lower fixed beneficial mutations, which directly contradict to the idea that mutations can add up indefinitely."

Again, there is a difference between fixed mutations and all mutations, and a difference between fixed mutations in a laboratory setting and fixed mutations beyond a laboratory setting, as well as all mutations in a laboratory setting and all mutations not in a laboratory setting.

" mutations should be random, and when there is no selection pressure, more mutation should survive and result in more diversified environment"


This is also incorrect because fixed mutations must be selected for by natural selection. ie selection pressures are necessary for a diversified environment, without selection, mutations fixate at a lower rate, However they do not simply stop occurring.
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
I can only hope that you are at least beginning to understand why your comments listed above, are incorrect. There is nothing wrong with making mistakes, but there is something wrong when they are not acknowledged. A statement should be known before it is made, or if it is found to be incorrect, it should be adjusted.

Rather than blindly judging these research papers, you should read them, all 3 of them that we have discussed thus far. Digest them, understand them as if you yourself had performed the research. And keep asking questions until you understand them like they were your own publications. But don't continue to state that they are something that they're not.
 
Last edited:
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
@dcalling

You keep making false statements over and over again, yet you aren't even acknowledging them. Below, I have listed a handfull.

"If the mutations are really beneficial, why are they stopped fixation? "
They haven't stopped.

You state that research conclusions contradict one another, but they don't.

You claim that it is different researchers reaching different conclusions, yet its the same lead author and researcher, reaching conclusions that align with one another.

"I never said 66k generation is enough to evolve limbs, I simply state the fact that after 66k generations, fixed benifitial mutations are slowing down, instead of as you stated they should keep accumulating."

There is a difference between stating that all mutations will magically stop, and stating that in a fixed and stable environment (which only exists in a laboratory), mutations will stop fixating.

I might have used "stopped" accidentally once, but most of the quotes I used " fixed benifitial mutations are slowing down" as you quoted above. But you should know what I meant given all my other responses.

Even though you and I have different ideas and we totally disagree on many topics, I never accused you of "making false statements over and over again". I can tell you right here that I am making my arguments in good faith, I wish you can say the same.


You stated "Which means there is a mutation limit, at least with our current knowledge of genes, that there is finite number of mutations at different points."

A finite number of mutations at different points, however, as seen in these research papers, that number of points and that number of combinations of points, is extraordinarily vast in number, to the extent that after 60,000 generations the subjects have undergone tens of billions of genetic changes, and are still undergoing mutation and continued genetic and phenotypic variation. And this is further in a fixed and stable environment that opposes fixation.

You might try your best to explain this away, but you won't even acknowledge that there is a possibility of a mutation limit? Even when faced with real data, and that your explainations are only hypthesis?

"are progressively lower fixed beneficial mutations, which directly contradict to the idea that mutations can add up indefinitely."

Again, there is a difference between fixed mutations and all mutations, and a difference between fixed mutations in a laboratory setting and fixed mutations beyond a laboratory setting, as well as all mutations in a laboratory setting and all mutations not in a laboratory setting.

" mutations should be random, and when there is no selection pressure, more mutation should survive and result in more diversified environment"


This is also incorrect because fixed mutations must be selected for by natural selection. ie selection pressures are necessary for a diversified environment, without selection, mutations fixate at a lower rate, However they do not simply stop occurring.
WHY is my statement " mutations should be random, and when there is no selection pressure, more mutation should survive and result in more diversified environment" in correct?

You said "without selection, mutations fixate at a lower rate", which is totally false. When there is no selection (i.e. all variations live), fixation should pickup since all different strains survives (or the strain with the fastest reproduce rate should manifest more), don't you agree? You explain more in detail since your current answer is not satisfitary.
 
Last edited:
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
I might have used "stopped" accidentally once, but most of the quotes I used " fixed benifitial mutations are slowing down" as you quoted above. But you should know what I meant given all my other responses.

Even though you and I have different ideas and we totally disagree on many topics, I never accused you of "making false statements over and over again". I can tell you right here that I am making my arguments in good faith, I wish you can say the same.

Well thank you. Its a controversial topic, whether or not evolution is true or not. Many people make aggressive claims, even in topics that are unclear. I just want to be safe, and try to be honest, so I appreciate the above response.

You might try your best to explain this away, but you won't even acknowledge that there is a possibility of a mutation limit? Even when faced with real data, and that your explainations are only hypthesis?

There is a limit to how much DNA can change, because there is a limit to how much DNA there is. However, what is possible is such an incredibly vast amount of change, that it becomes trivial to try to use this limit, to say that evolution didnt happen. As we both can see, in the experiment which uses real data, we see, literally tens of billions of mutations over tens of thousands of generations, and the organisms are still going strong.

As a matter of fact, right now, I am going to copy some graphs from the research articles.

upload_2018-2-24_12-16-36.png

upload_2018-2-24_12-17-48.png


The amount of genetic change that is possible in a lifeform, such as these e.coli, and every other animal, is so extraordinarily vast. And all of this is happening in a fixed environment, in a beaker, literally in a glass jar. Imagine the complexity of environmental stresses across the entire planet, and imagine the amount of environmental selection, in combination with the tens of billions, if not trillions of mutations, that happen in just this one species of bacteria alone.

Its mind boggling the amount of change that can occur, genetically and phenotypically, in life, on earth.

So yes, there has to be a physical limit somewhere. But, lets say for example, after trillions of generations and trillions of mutations later, lets say this bacteria finally reaches peak fitness. All you have to do is take that fit bacteria and put it into a new environment, and it is no longer at peak fitness. And with that, new environmental stresses select for new mutations to be fixated, and the process starts all over again.

So yes there is a limit somewhere, these bacteria may some day, about countless generations and countless mutations, they may reach that peak fitness position in that one glass jar. But think about all of life around all of earth, and just try to imagine how incredibly vast genetic and phenotypic changes can be.

I should also add that, mutations are, often products of error in transcription and translation of DNA. Mutations will always occur, so long as DNA is DNA. So long as life, is life as God has created it, it will by its nature, change. Sunlight and subatomic particles also pierce our DNA and create mutations. So long as as DNA can be damaged by outside sources, or driven by environmental change, or so long as it makes transcription and translation errors. There will forever be mutations. Its just the way we exist. And the only limit to that, is death. But so long as we live, we will mutate.

WHY is my statement " mutations should be random, and when there is no selection pressure, more mutation should survive and result in more diversified environment" in correct?

It takes environmental stresses to naturally select for mutations, thereby fixating them, so that they proceed through generations, and this results in an internal variation.

If there is no environmental stress, this could only be possible in an environment where a population has reached peak fitness. If a population is at peak fitness, new mutations will not become fixed because they are out-competed by already existent superior mutations. And there cannot be a beneficial mutation in an organism at peak fitness, because it is already at peak fitness.

And if new mutations are not fixated, then there is no production of diversity within a population.

Mutations will still occur at random, and variation will come into existence. However, if the population is already at peak fitness, the peak fit, will out compete the variants, and the variants will go extinct. At least if in a stable and confined environment.

You said "without selection, mutations fixate at a lower rate", which is totally false. When there is no selection (i.e. all variations live), fixation should pickup since all different strains survives (or the strain with the fastest reproduce rate should manifest more), don't you agree? You explain more in detail since your current answer is not satisfitary.

Read above. This is exactly what the e.coli experiment is explaining. I'll gather some more quotes. I should have said, with lower amounts of selective pressure, mutations will fixate at a lower rate as the organism approaches peak fitness. Or perhaps I could have said, with limited selective pressures, mutations fixate at a lower rate.

A fixed environment, is an environment in which selective pressures are limited. As the E.coli reach peak fitness (which can only exist in an environment that is stable and remains the same, without alternating or any outside selective pressures) beneficial mutations cannot fixate in their lineage, because they are already at peak fitness. But again, this peak fitness cannot occur in environments that are ever changing.

That's what I meant in my statement above. Without environmental pressures that are changing what it means to be "peak in fitness", organisms approach peak fitness, which by definition, means they cannot become more fit and cannot accumulate fixated beneficial mutations. Because no mutation can benefit an organisms that is already at optimal fitness. Therefore, there cannot be a beneficial mutation.

And this is in part, why rate of fitness improvement and rate of fixation of beneficial mutations, both are decreasing, because the organisms are approaching peak fitness, and fixation is decreasing.

You suggested that without selection, all variants would survive. Maybe If there is no outside pressure on a population, or any pressure that would cause an organism not to reach peak fitness, then variants would not survive, because they would be out-competed by the most fit.
 
Last edited:
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
Really all of this is just proof of evolution. The e.coli experiment is an observable display of how quantitatively vast, variation can be, genetically and phenotypically. It displays mutations, it displays fixation. Yes the fixation decreases, as populations approach peak fitness. However, that logically would have to happen. As something becomes more and more fit for its environment, there can only be less and less beneficial mutations.

Its like saying, as a student studies more and more, you can only give beneficial information to them less and less, because they already know what you try to inform them of.

It displays an incredible number of mutations over an incredibly short amount of time as well. Tens of billions. And as a result of these genetic changes, subsequently, there are phenotypic changes and changes in morphology.

Many young earthers, do not even admit beneficial mutations exist. Many do not admit that genetic variation can even arise in such a way, and that its all, pre-existing information and adaptation.

And yet, here it all is in black and white. The only thing we dont see is the bacteria growing legs and walking out of the jar. But again, evolution would never predict such an occurrence to begin with, not in such a brief amount of time with such limited environmental stresses.
 
Upvote 0

dcalling

Senior Member
Jan 31, 2014
3,190
325
✟115,271.00
Faith
Non-Denom
Marital Status
Married
Well thank you. Its a controversial topic, whether or not evolution is true or not. Many people make aggressive claims, even in topics that are unclear. I just want to be safe, and try to be honest, so I appreciate the above response.



There is a limit to how much DNA can change, because there is a limit to how much DNA there is. However, what is possible is such an incredibly vast amount of change, that it becomes trivial to try to use this limit, to say that evolution didnt happen. As we both can see, in the experiment which uses real data, we see, literally tens of billions of mutations over tens of thousands of generations, and the organisms are still going strong.

As a matter of fact, right now, I am going to copy some graphs from the research articles.

View attachment 221450
View attachment 221451

That is not my main point (i.e. limitation due to length of DNA). My hypothesis is some mutation will be naturally hard or impossible to happen.
The bases of that hypthesis is:
1. some organism/DNA strand changed little over millions of years.
2. DNA is a lot like coding. From time to time when we change code, it is much easier to re-design from ground up (exclude certain basic libraries) instead of doing simple refactors.
3. Complex codes are sometimes not compatible. a complex system sometimes needs multiple pieces developed seperately, they can't function without the other pieces, and multiple tests and collaboration has to be done to ensure their functionality. How do we know DNA does not require such things?

And from your graph above, even for 20k generations, you can see the blue circle (accumulated mutations) fits better on a log curve, but the scientists used a line to represent trend. I would say any computer sciense student will agree that line fits better on a log line, Don't you agree? Do you have the 60k graph?

The amount of genetic change that is possible in a lifeform, such as these e.coli, and every other animal, is so extraordinarily vast. And all of this is happening in a fixed environment, in a beaker, literally in a glass jar. Imagine the complexity of environmental stresses across the entire planet, and imagine the amount of environmental selection, in combination with the tens of billions, if not trillions of mutations, that happen in just this one species of bacteria alone.

Its mind boggling the amount of change that can occur, genetically and phenotypically, in life, on earth.

So yes, there has to be a physical limit somewhere. But, lets say for example, after trillions of generations and trillions of mutations later, lets say this bacteria finally reaches peak fitness. All you have to do is take that fit bacteria and put it into a new environment, and it is no longer at peak fitness. And with that, new environmental stresses select for new mutations to be fixated, and the process starts all over again.

So yes there is a limit somewhere, these bacteria may some day, about countless generations and countless mutations, they may reach that peak fitness position in that one glass jar. But think about all of life around all of earth, and just try to imagine how incredibly vast genetic and phenotypic changes can be.

I should also add that, mutations are, often products of error in transcription and translation of DNA. Mutations will always occur, so long as DNA is DNA. So long as life, is life as God has created it, it will by its nature, change. Sunlight and subatomic particles also pierce our DNA and create mutations. So long as as DNA can be damaged by outside sources, or driven by environmental change, or so long as it makes transcription and translation errors. There will forever be mutations. Its just the way we exist. And the only limit to that, is death. But so long as we live, we will mutate.
It takes environmental stresses to naturally select for mutations, thereby fixating them, so that they proceed through generations, and this results in an internal variation.

If there is no environmental stress, this could only be possible in an environment where a population has reached peak fitness. If a population is at peak fitness, new mutations will not become fixed because they are out-competed by already existent superior mutations. And there cannot be a beneficial mutation in an organism at peak fitness, because it is already at peak fitness.

And if new mutations are not fixated, then there is no production of diversity within a population.

Mutations will still occur at random, and variation will come into existence. However, if the population is already at peak fitness, the peak fit, will out compete the variants, and the variants will go extinct. At least if in a stable and confined environment.



Read above. This is exactly what the e.coli experiment is explaining. I'll gather some more quotes. I should have said, with lower amounts of selective pressure, mutations will fixate at a lower rate as the organism approaches peak fitness. Or perhaps I could have said, with limited selective pressures, mutations fixate at a lower rate.

A fixed environment, is an environment in which selective pressures are limited. As the E.coli reach peak fitness (which can only exist in an environment that is stable and remains the same, without alternating or any outside selective pressures) beneficial mutations cannot fixate in their lineage, because they are already at peak fitness. But again, this peak fitness cannot occur in environments that are ever changing.

That's what I meant in my statement above. Without environmental pressures that are changing what it means to be "peak in fitness", organisms approach peak fitness, which by definition, means they cannot become more fit and cannot accumulate fixated beneficial mutations. Because no mutation can benefit an organisms that is already at optimal fitness. Therefore, there cannot be a beneficial mutation.

And this is in part, why rate of fitness improvement and rate of fixation of beneficial mutations, both are decreasing, because the organisms are approaching peak fitness, and fixation is decreasing.

You suggested that without selection, all variants would survive. Maybe If there is no outside pressure on a population, or any pressure that would cause an organism not to reach peak fitness, then variants would not survive, because they would be out-competed by the most fit.

I still think your explanation lacks. So your argument is, once it approaches peak fitness for the environment, since it is the peak, any other mutations will be selected out (with little remains). So under the same enviroment only the peak fitness mutation show up and all other slows down (due to got selected out), right?

My counter to it is:
1. Do you have the evidence of majority of the e.coli after 60k generations has the same DNA composition (since it is the peak fitness)?
2. Since there are enough food and space, other mutations should show up as well, since they can survive, just not in big number right?
3. How do you define peak fitness? Since there is enough food, the only thing about peak fitness is who can grow/split faster right?
 
Upvote 0

Job 33:6

Well-Known Member
Jun 15, 2017
9,396
3,190
Hartford, Connecticut
✟356,318.00
Country
United States
Gender
Male
Faith
Christian
Marital Status
Married
Politics
US-Republican
1. Changed "little" is a vague or even subjective term. This statement of yours is without meaning. Regardless though, changed "little" is not to say that something has not changed at all. And since you used the word "some", i suppose you could also state that "some" have changed more than just a little.
2. You're just talking.
3. I suggest you read the 2017 research paper, they talk about this.

You asked if I have a graph from the 60k research. Did you not recognize it when I posted it? Look at each image again, and tell me what you see.

1. The e.coli is still mutating, it has not reached peak fitness. However, as it approaches peak fitness, fixed mutations are decreasing. This is all outlined in the research.
2. Yes they are still mutating. Some are mutating faster than they were at the start of the experiment (as I pointed out before, when you told me I was wrong), some are mutating slower than they were at the start. These organisms would continue to mutate even if there were no more space. If there were not enough food, then i suppose they would starve to death.
3. Read the research, they discuss this.
 
Last edited:
Upvote 0